FI885464A - Asyylioksiasyylihydrolaasi ja sen käyttö - Google Patents
Asyylioksiasyylihydrolaasi ja sen käyttö Download PDFInfo
- Publication number
- FI885464A FI885464A FI885464A FI885464A FI885464A FI 885464 A FI885464 A FI 885464A FI 885464 A FI885464 A FI 885464A FI 885464 A FI885464 A FI 885464A FI 885464 A FI885464 A FI 885464A
- Authority
- FI
- Finland
- Prior art keywords
- lps
- fatty acids
- acyloxyacyl hydrolase
- gram
- negative bacterial
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0275—Salmonella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US86842886 | 1986-05-28 | ||
US06/868,428 US4929604A (en) | 1986-05-28 | 1986-05-28 | Lipopolysaccharides of reduced toxicity and the production thereof |
US5304487A | 1987-05-22 | 1987-05-22 | |
US5304487 | 1987-05-22 | ||
PCT/US1987/001244 WO1987007297A1 (en) | 1986-05-28 | 1987-05-27 | Lipopolysaccharides of reduced toxicity and the production thereof |
US8701244 | 1987-05-27 |
Publications (4)
Publication Number | Publication Date |
---|---|
FI885464A true FI885464A (fi) | 1988-11-24 |
FI885464A0 FI885464A0 (fi) | 1988-11-24 |
FI95599B FI95599B (fi) | 1995-11-15 |
FI95599C FI95599C (fi) | 1996-02-26 |
Family
ID=26731375
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI885464A FI95599C (fi) | 1986-05-28 | 1988-11-24 | Asyylioksiasyylihydrolaasi ja sen käyttö |
Country Status (8)
Country | Link |
---|---|
US (3) | US4929604A (fi) |
EP (1) | EP0306496B1 (fi) |
JP (1) | JPH04504349A (fi) |
AT (1) | ATE130032T1 (fi) |
AU (1) | AU610509B2 (fi) |
DE (1) | DE3751588T2 (fi) |
FI (1) | FI95599C (fi) |
WO (1) | WO1987007297A1 (fi) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5597573A (en) * | 1989-05-04 | 1997-01-28 | Igen, Inc. | Lipid-A analogs: new monosaccharide and disaccharide intermediates for eliciting therapeutic antibodies and for antitumor and antiviral activities |
FR2648350B1 (fr) * | 1989-06-20 | 1994-07-01 | Roussel Uclaf | Utilisation de lipopolysaccharides extraits de bacteries gram(-) pour la fabrication d'un medicament facilitant la cicatrisation de la peau |
JPH04270965A (ja) * | 1990-05-18 | 1992-09-28 | Burton W Blais | オリゴペプタイド吸着担体の調製方法、及びこれを使用したリポ多糖類の検定と除去方法 |
US5281583A (en) * | 1990-08-20 | 1994-01-25 | Den'ichi Mizuno | LPS-containing analgesics and veterinary analgesics |
US5281520A (en) * | 1990-09-12 | 1994-01-25 | Zymogenetics, Inc. | Method for producing acyloxyacyl hydrolase |
US5593969A (en) * | 1991-09-03 | 1997-01-14 | Igen Incorporated | Lipid-A analogs: monosaccharide and dissaccharide compounds for inhibiting binding of lipid A receptors to lipid A receptors |
AU660325B2 (en) * | 1991-10-11 | 1995-06-22 | Eisai Co. Ltd. | Anti-endotoxin compounds and related molecules and methods |
US5530113A (en) * | 1991-10-11 | 1996-06-25 | Eisai Co., Ltd. | Anti-endotoxin compounds |
US5824310A (en) * | 1991-10-22 | 1998-10-20 | The United States Of America As Represented By The Department Of Health And Human Services | Lipopplysaccharide conjugate vaccines |
IL105131A (en) * | 1992-03-27 | 2000-06-01 | Igen Inc | Compounds and compositions containing such compounds comprising lipid-A analogs for eliciting therapeutic antibodies |
US5439819A (en) * | 1993-08-27 | 1995-08-08 | The Regents Of The University Of California | Chimeric protein tyrosine kinases |
CA2176237A1 (en) * | 1993-11-10 | 1995-05-18 | Richard P. Darveau | Treatment of bacterially-induced inflammatory diseases |
US5648343A (en) * | 1994-02-28 | 1997-07-15 | The University Of Georgia Research Foundation | Method for treating LPS-mediated disorders |
DE69506212T2 (de) * | 1994-04-20 | 1999-08-05 | U.S. Department Of The Army, Fort Frederick, Md. | Impfstoff gegen gram-negative bakterielle infektionen |
US6887483B2 (en) * | 1995-12-01 | 2005-05-03 | University Of Iowa Research Foundation | Non-toxic mutants of pathogenic gram-negative bacteria |
US6685949B1 (en) | 1998-01-13 | 2004-02-03 | The United States Of America As Represented By The Department Of Health & Human Services | Lipooligosaccharide based vaccine for prevention of moraxella (branhamella)catarrhalis infections in humans |
US6207157B1 (en) * | 1996-04-23 | 2001-03-27 | The United States Of America As Represented By The Department Of Health And Human Services | Conjugate vaccine for nontypeable Haemophilus influenzae |
US6172220B1 (en) | 1997-01-21 | 2001-01-09 | Board Of Regents Of University Of Nebraska | Isolated algal lipopolysaccharides and use of same to inhibit endotoxin-initiated sepsis |
US6444654B1 (en) | 1997-01-21 | 2002-09-03 | Board Of Regents Of University Of Nebraska | Isolated asgal lipopolysaccharides and use of same to inhibit innate immune response |
EP1001805A1 (en) * | 1997-06-18 | 2000-05-24 | The Rockefeller University | Methods for identifying antibodies and peptides useful in the treatment of septic shock and experimental arthritis and uses thereof |
US6645503B1 (en) * | 1998-03-10 | 2003-11-11 | Wyeth Holdings Corporation | Antigenic conjugates of conserved lipopolysaccharides of gram negative bacteria |
US6531131B1 (en) | 1999-08-10 | 2003-03-11 | The United States Of America As Represented By The Department Of Health And Human Services | Conjugate vaccine for Neisseria meningitidis |
WO2001025254A2 (en) * | 1999-10-04 | 2001-04-12 | University Of Maryland Biotechnology Institute | Novel adjuvant comprising a lipopolysaccharide antagonist |
WO2001032697A2 (en) * | 1999-11-05 | 2001-05-10 | L'unite De Recherche En Biologie Moleculaire (Urbm) Des Facultes Universitaires Notre Dame De La Paix (Fundp) | Virulence genes and proteins from brucella melitensis, and their use |
US20030068324A1 (en) * | 2001-04-06 | 2003-04-10 | Jean-Michel Fournier | Conjugate vaccine composed of the polysaccharide moiety of the lipopolysaccharide of Vibrio cholerae O139 bound to tetanus toxoid |
KR100456681B1 (ko) * | 2002-05-22 | 2004-11-10 | 주식회사 대웅 | 박테리아의 염색체 dna 파쇄물과 비독성리포폴리사카라이드를 포함하는 면역강화 및 조절 조성물 |
EP1996715B1 (en) * | 2005-11-23 | 2012-04-25 | National Research Council Of Canada | Bacterial antigens and uses thereof |
EP2429658B1 (fr) | 2009-05-14 | 2016-04-20 | Sanofi Pasteur | Procédé pour adjuver le lipopolysaccharide (LPS) des bactéries à gram-négatif |
WO2010130898A2 (fr) | 2009-05-14 | 2010-11-18 | Sanofi Pasteur | Vaccin meningocoque a base de lipooligosaccharide (los) provenant de souches modifiees de neisseria meningitidis d'immunotype l6 |
EP2620162A1 (de) | 2012-01-27 | 2013-07-31 | Life Science Inkubator | Enzym-Polymer-Konjugat zur Endotoxin-Detoxifikation |
KR102125600B1 (ko) | 2013-06-04 | 2020-06-23 | 페트르 젠나디에비치 아파린 | 개질된 내독성 세균 지질다당류(변형체), 개질된 지질다당류들(변형체들)의 조합물, 및 이를 함유한 백신(변형체) 및 약제 조성물(변형체) |
US11052142B2 (en) | 2013-06-04 | 2021-07-06 | Petr G. Aparin | Modified endotoxic bacteria lipopolysaccharide (variants), combination of modified lipopolysaccharides (variants) and, containing same, a vaccine (variants) and a pharmaceutical composition (variants) |
WO2020087160A1 (en) * | 2018-10-29 | 2020-05-07 | Ottawa Hospital Research Institute | Genetically-engineered mesenchymal stem cells overexpressing aoah and uses thereof |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4057685A (en) * | 1972-02-02 | 1977-11-08 | Abbott Laboratories | Chemically modified endotoxin immunizing agent |
US4185090A (en) * | 1972-02-02 | 1980-01-22 | Abbott Laboratories | Chemically modified endotoxin immunizing agent |
US4148877A (en) * | 1975-12-29 | 1979-04-10 | Choay S. A. | Fraction capable of inducing in vivo a resistance to bacterial infections, process for obtaining said fraction from bacteria and drugs containing said fraction |
FR2393065A1 (fr) * | 1977-05-31 | 1978-12-29 | Merieux Inst | Procede de separation de lipides d'endotoxines bacteriennes et notamment d'endotoxine de bordetella pertussis |
US4436728A (en) * | 1982-05-26 | 1984-03-13 | Ribi Immunochem Research, Inc. | Refined detoxified endotoxin product |
US4435386A (en) * | 1982-05-26 | 1984-03-06 | Ribi Immunochem Research, Inc. | Refined detoxified endotoxin product |
US4505900A (en) * | 1982-05-26 | 1985-03-19 | Ribi Immunochem Research, Inc. | Refined detoxified endotoxin product |
US4505899A (en) * | 1982-05-26 | 1985-03-19 | Ribi Immunochem Research, Inc. | Refined detoxified endotoxin product |
US4436727A (en) * | 1982-05-26 | 1984-03-13 | Ribi Immunochem Research, Inc. | Refined detoxified endotoxin product |
US4663306A (en) * | 1983-09-23 | 1987-05-05 | Ribi Immunochem Research, Inc. | Pyridine-soluble extract-refined detoxified endotoxin composition and use |
GR860379B (en) * | 1985-02-22 | 1986-06-11 | Akzo Nv | Novel disaccharide and trisaccharide derivatives of the lipid a type |
US4677194A (en) * | 1985-08-09 | 1987-06-30 | Biotech Research Laboratories, Inc. | Isolation of an endotoxin inactivator from human plasma |
-
1986
- 1986-05-28 US US06/868,428 patent/US4929604A/en not_active Expired - Fee Related
-
1987
- 1987-05-27 AU AU75807/87A patent/AU610509B2/en not_active Ceased
- 1987-05-27 EP EP87903949A patent/EP0306496B1/en not_active Expired - Lifetime
- 1987-05-27 WO PCT/US1987/001244 patent/WO1987007297A1/en active IP Right Grant
- 1987-05-27 JP JP62503635A patent/JPH04504349A/ja active Pending
- 1987-05-27 AT AT87903949T patent/ATE130032T1/de not_active IP Right Cessation
- 1987-05-27 DE DE3751588T patent/DE3751588T2/de not_active Expired - Fee Related
-
1988
- 1988-11-24 FI FI885464A patent/FI95599C/fi not_active IP Right Cessation
-
1989
- 1989-03-15 US US07/323,679 patent/US5013661A/en not_active Expired - Fee Related
-
1991
- 1991-07-08 US US07/728,763 patent/US5200184A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE3751588T2 (de) | 1996-03-21 |
EP0306496B1 (en) | 1995-11-08 |
EP0306496A1 (en) | 1989-03-15 |
ATE130032T1 (de) | 1995-11-15 |
FI95599C (fi) | 1996-02-26 |
AU610509B2 (en) | 1991-05-23 |
US5200184A (en) | 1993-04-06 |
FI885464A0 (fi) | 1988-11-24 |
US4929604A (en) | 1990-05-29 |
WO1987007297A1 (en) | 1987-12-03 |
DE3751588D1 (de) | 1995-12-14 |
US5013661A (en) | 1991-05-07 |
FI95599B (fi) | 1995-11-15 |
JPH04504349A (ja) | 1992-08-06 |
AU7580787A (en) | 1987-12-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
BB | Publication of examined application | ||
MM | Patent lapsed | ||
MM | Patent lapsed |
Owner name: BOARD OF REGENTS, THE UNIVERSITY OF |