FI884049A - LAKTAMDERIVAT. - Google Patents

Abstract

The invention relates to pyrido- and azepino(4,3-b)indol- 1-one derivatives having the general formula (I) <IMAGE> where Im is an imidazole group of the formula <IMAGE> or <IMAGE> and R<1> is a hydrogen atom or a group selected from the following: C1-6alkyl, C3-4alkenyl, C3-10alkynyl, C3-7cycloalkyl, C3- 7-cycloalkyl-C1-4alkyl, phenyl or phenyl-C1-3alkyl, phenylmethoxymethyl, phenoxyethyl, phenoxymethyl, -CO2R<5>, -COR<5>, -CONR<5>R<6> or -SO2R<5> (where R<5> and R<6>, which can be identical or different, are each a hydrogen atom, a C1-4alkyl group or C3-7cycloalkyl group, or a phenyl group or phenylC1-4-alkyl group, where the phenyl group has been substituted at will by one or more C1-4alkyl, C1-4alkoxy or hydroxyl groups or by a halogen atom, provided that R<5> is not a hydrogen atom when R<1> is a -CO2R<5> or a -SO2R<5> group); one of the groups R<2>, R<3> and R<4> is a hydrogen atom or a C1-6alkyl, C3-7cycloalkyl, C3-6alkenyl, phenyl or phenyl C1-3alkyl group, and each of the two other groups, which can be identical or different, is a hydrogen atom or a C1-4alkyl group; n is 2 or 3; and the physiologically acceptable salts and solvates thereof. These compounds are effective and selective antagonists of the 5-hydroxytryptamine effect in 5-HT3 receptors and they are of use, for example, in treating psychotic diseases, anxiety feelings and nausea and vomiting.