ES2143630T3 - AZABICICLOALKYL DERIVATIVES OF IMIDAZO (1,5-A) INDOL-3-ONA USED AS 5HT3 ANTAGONISTS. - Google Patents

AZABICICLOALKYL DERIVATIVES OF IMIDAZO (1,5-A) INDOL-3-ONA USED AS 5HT3 ANTAGONISTS.

Info

Publication number
ES2143630T3
ES2143630T3 ES95919370T ES95919370T ES2143630T3 ES 2143630 T3 ES2143630 T3 ES 2143630T3 ES 95919370 T ES95919370 T ES 95919370T ES 95919370 T ES95919370 T ES 95919370T ES 2143630 T3 ES2143630 T3 ES 2143630T3
Authority
ES
Spain
Prior art keywords
sub
azabicicloalkyl
imidazo
indol
antagonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95919370T
Other languages
Spanish (es)
Inventor
Mario Varasi
Franco Heidempergher
Carla Caccia
Patricia Salvati
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Pharmacia and Upjohn SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn SpA filed Critical Pharmacia and Upjohn SpA
Application granted granted Critical
Publication of ES2143630T3 publication Critical patent/ES2143630T3/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof

Abstract

COMPUESTOS ANTAGONISTAS RECEPTORES 5-HT 3 NOVEDOSOS DE FORMULA (I) DONDE CADA R{SUB,1} Y R{SUB,2}, QUE PUEDEN SER IGUALES O DISTINTOS, ES HIDROGENO, HALOGENO, HIDROXI, CIANO, C{SUB,1}-C{SUB,6}ALQUIL, CF{SUB,3}, C{SUB,1}-C{SUB,6}ALCOXI, C{SUB,1}-C{SUB,6}ALQUITIO, FORMIL, C{SUB,2}-C{SUB,6}ALCANOIL, CARBOXI, C{SUB,1}-C{SUB,6}ALCOXI-CARBONIL, NITRO, -N (R{SUB,4}R{SUB,5}) EN EL QUE CADA R{SUB,4} Y R{SUB,5} SON INDEPENDIENTEMENTE HIDROGENO, C{SUB,1}-C{SUB,6}ALQUIL, FORMIL O C{SUB,2}-C{SUB,6}ALCANOIL; O UN GRUPO (R{SUB,6}R{SUB,7}) NSO{SUB,2}, EN EL QUE CADA R{SUB,6} Y R{SUB,7} SON INDEPENDIENTEMENTE HIDROGENO O C{SUB,1}-C{SUB,6}ALQUIL; R{SUB,3} ES UN GRUPO (A) O (B), DONDE N ES UN ENTERO DE 1 O 2 Y R{SUB,8} ES HIDROGENO, C{SUB,1}-C{SUB,6}ALQUIL SUSTITUIDO O NO SUSTITUIDO POR FENIL, C{SUB,2}-C{SUB,4}ALQUENIL, C{SUB,2}-C{SUB,4}ALQUINIL, FORMIL O C{SUB,2}-C{SUB,6}ALCANOIL; Y LAS SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS.ANTAGONIST RECEIVING COMPOUNDS 5-HT 3 NEW FORMULA (I) WHERE EACH R {SUB, 1} AND R {SUB, 2}, WHICH MAY BE THE SAME OR DIFFERENT, IS HYDROGEN, HALOGEN, HYDROXY, CIAN, C {SUB, 1} -C {SUB, 6} ALQUIL, CF {SUB, 3}, C {SUB, 1} -C {SUB, 6} ALCOXI, C {SUB, 1} -C {SUB, 6} ALQUITIO, FORMIL, C { SUB, 2} -C {SUB, 6} ALCANOIL, CARBOXI, C {SUB, 1} -C {SUB, 6} ALCOXI-CARBONIL, NITRO, -N (R {SUB, 4} R {SUB, 5}) IN WHICH EACH R {SUB, 4} AND R {SUB, 5} ARE INDEPENDENTLY HYDROGEN, C {SUB, 1} -C {SUB, 6} ALQUIL, FORMIL OC {SUB, 2} -C {SUB, 6} ALCANOIL ; OR A GROUP (R {SUB, 6} R {SUB, 7}) NSO {SUB, 2}, IN WHICH EACH R {SUB, 6} AND R {SUB, 7} ARE INDEPENDENTLY HYDROGEN OC {SUB, 1} - C {SUB, 6} ALKYL; R {SUB, 3} IS A GROUP (A) O (B), WHERE N IS AN INTEGER OF 1 OR 2 AND R {SUB, 8} IS HYDROGEN, C {SUB, 1} -C {SUB, 6} SUBSTITUTED RENT OR NOT SUBSTITUTED FOR PHENYL, C {SUB, 2} -C {SUB, 4} ALQUENIL, C {SUB, 2} -C {SUB, 4} ALQUINIL, FORMIL OC {SUB, 2} -C {SUB, 6} ALCANOIL; AND THE PHARMACEUTICALLY ACCEPTABLE SALTS OF THEM.

ES95919370T 1994-05-25 1995-05-02 AZABICICLOALKYL DERIVATIVES OF IMIDAZO (1,5-A) INDOL-3-ONA USED AS 5HT3 ANTAGONISTS. Expired - Lifetime ES2143630T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9410441A GB9410441D0 (en) 1994-05-25 1994-05-25 Azabicycloakyl derivatives of imidazo (1,5-a) indol-3-one and process for their preparation

Publications (1)

Publication Number Publication Date
ES2143630T3 true ES2143630T3 (en) 2000-05-16

Family

ID=10755671

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95919370T Expired - Lifetime ES2143630T3 (en) 1994-05-25 1995-05-02 AZABICICLOALKYL DERIVATIVES OF IMIDAZO (1,5-A) INDOL-3-ONA USED AS 5HT3 ANTAGONISTS.

Country Status (8)

Country Link
US (1) US5637596A (en)
EP (1) EP0711299B1 (en)
JP (1) JP3615550B2 (en)
CA (1) CA2166621A1 (en)
DE (1) DE69514315T2 (en)
ES (1) ES2143630T3 (en)
GB (1) GB9410441D0 (en)
WO (1) WO1995032209A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6054756A (en) 1992-07-24 2000-04-25 Tessera, Inc. Connection components with frangible leads and bus
US20020151111A1 (en) * 1995-05-08 2002-10-17 Tessera, Inc. P-connection components with frangible leads and bus
JP2002518331A (en) * 1998-06-19 2002-06-25 イーライ・リリー・アンド・カンパニー Inhibition of serotonin reuptake
IT1303123B1 (en) * 1998-10-13 2000-10-30 Rotta Research Lab BASIC DERIVATIVES OF BENZ (E) ISOINDOL-1-ONI AND PIRROLE (3,4-C) CHINOLIN-1-ONI WITH ACTIVITY 5HT3 ANTAGONIST, THEIR PREPARATION AND
FR2797630B1 (en) * 1999-08-20 2005-04-29 Univ Caen Basse Normandie PYRROLO [1,2-a] QUINOXALINE ETHER DERIVATIVES, PROCESS FOR PREPARING THEM AND THEIR THERAPEUTIC APPLICATION
US8697722B2 (en) * 2007-11-02 2014-04-15 Sri International Nicotinic acetylcholine receptor modulators
EP2523562B1 (en) 2010-01-11 2019-01-02 Astraea Therapeutics, LLC Nicotinic acetylcholine receptor modulators
CN113583000A (en) * 2021-07-09 2021-11-02 成都大学 Method for preparing imidazo [1,5-a ] indol-3-one
CN113582999A (en) * 2021-07-09 2021-11-02 成都大学 Method for preparing imidazo [1,5-a ] indole compound

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3565902A (en) * 1967-09-15 1971-02-23 American Cyanamid Co 1,2-dihydro-3h-imidazo(1,5-a)indol-3-ones and 3-thiones
GB9106571D0 (en) * 1991-03-27 1991-05-15 Erba Carlo Spa Derivatives of substituted imidazol-2-one and process for their preparation
GB9201749D0 (en) * 1992-01-28 1992-03-11 Smithkline Beecham Plc Medicaments
GB9212486D0 (en) * 1992-06-12 1992-07-22 Erba Carlo Spa Derivatives of substituted imidazo benzoxazin-1-one and process for their preparation

Also Published As

Publication number Publication date
JP3615550B2 (en) 2005-02-02
WO1995032209A1 (en) 1995-11-30
CA2166621A1 (en) 1995-11-30
US5637596A (en) 1997-06-10
DE69514315T2 (en) 2000-07-27
DE69514315D1 (en) 2000-02-10
JPH09500913A (en) 1997-01-28
EP0711299A1 (en) 1996-05-15
GB9410441D0 (en) 1994-07-13
EP0711299B1 (en) 2000-01-05

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