ES2143630T3 - AZABICICLOALKYL DERIVATIVES OF IMIDAZO (1,5-A) INDOL-3-ONA USED AS 5HT3 ANTAGONISTS. - Google Patents
AZABICICLOALKYL DERIVATIVES OF IMIDAZO (1,5-A) INDOL-3-ONA USED AS 5HT3 ANTAGONISTS.Info
- Publication number
- ES2143630T3 ES2143630T3 ES95919370T ES95919370T ES2143630T3 ES 2143630 T3 ES2143630 T3 ES 2143630T3 ES 95919370 T ES95919370 T ES 95919370T ES 95919370 T ES95919370 T ES 95919370T ES 2143630 T3 ES2143630 T3 ES 2143630T3
- Authority
- ES
- Spain
- Prior art keywords
- sub
- azabicicloalkyl
- imidazo
- indol
- antagonists
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
COMPUESTOS ANTAGONISTAS RECEPTORES 5-HT 3 NOVEDOSOS DE FORMULA (I) DONDE CADA R{SUB,1} Y R{SUB,2}, QUE PUEDEN SER IGUALES O DISTINTOS, ES HIDROGENO, HALOGENO, HIDROXI, CIANO, C{SUB,1}-C{SUB,6}ALQUIL, CF{SUB,3}, C{SUB,1}-C{SUB,6}ALCOXI, C{SUB,1}-C{SUB,6}ALQUITIO, FORMIL, C{SUB,2}-C{SUB,6}ALCANOIL, CARBOXI, C{SUB,1}-C{SUB,6}ALCOXI-CARBONIL, NITRO, -N (R{SUB,4}R{SUB,5}) EN EL QUE CADA R{SUB,4} Y R{SUB,5} SON INDEPENDIENTEMENTE HIDROGENO, C{SUB,1}-C{SUB,6}ALQUIL, FORMIL O C{SUB,2}-C{SUB,6}ALCANOIL; O UN GRUPO (R{SUB,6}R{SUB,7}) NSO{SUB,2}, EN EL QUE CADA R{SUB,6} Y R{SUB,7} SON INDEPENDIENTEMENTE HIDROGENO O C{SUB,1}-C{SUB,6}ALQUIL; R{SUB,3} ES UN GRUPO (A) O (B), DONDE N ES UN ENTERO DE 1 O 2 Y R{SUB,8} ES HIDROGENO, C{SUB,1}-C{SUB,6}ALQUIL SUSTITUIDO O NO SUSTITUIDO POR FENIL, C{SUB,2}-C{SUB,4}ALQUENIL, C{SUB,2}-C{SUB,4}ALQUINIL, FORMIL O C{SUB,2}-C{SUB,6}ALCANOIL; Y LAS SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS.ANTAGONIST RECEIVING COMPOUNDS 5-HT 3 NEW FORMULA (I) WHERE EACH R {SUB, 1} AND R {SUB, 2}, WHICH MAY BE THE SAME OR DIFFERENT, IS HYDROGEN, HALOGEN, HYDROXY, CIAN, C {SUB, 1} -C {SUB, 6} ALQUIL, CF {SUB, 3}, C {SUB, 1} -C {SUB, 6} ALCOXI, C {SUB, 1} -C {SUB, 6} ALQUITIO, FORMIL, C { SUB, 2} -C {SUB, 6} ALCANOIL, CARBOXI, C {SUB, 1} -C {SUB, 6} ALCOXI-CARBONIL, NITRO, -N (R {SUB, 4} R {SUB, 5}) IN WHICH EACH R {SUB, 4} AND R {SUB, 5} ARE INDEPENDENTLY HYDROGEN, C {SUB, 1} -C {SUB, 6} ALQUIL, FORMIL OC {SUB, 2} -C {SUB, 6} ALCANOIL ; OR A GROUP (R {SUB, 6} R {SUB, 7}) NSO {SUB, 2}, IN WHICH EACH R {SUB, 6} AND R {SUB, 7} ARE INDEPENDENTLY HYDROGEN OC {SUB, 1} - C {SUB, 6} ALKYL; R {SUB, 3} IS A GROUP (A) O (B), WHERE N IS AN INTEGER OF 1 OR 2 AND R {SUB, 8} IS HYDROGEN, C {SUB, 1} -C {SUB, 6} SUBSTITUTED RENT OR NOT SUBSTITUTED FOR PHENYL, C {SUB, 2} -C {SUB, 4} ALQUENIL, C {SUB, 2} -C {SUB, 4} ALQUINIL, FORMIL OC {SUB, 2} -C {SUB, 6} ALCANOIL; AND THE PHARMACEUTICALLY ACCEPTABLE SALTS OF THEM.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9410441A GB9410441D0 (en) | 1994-05-25 | 1994-05-25 | Azabicycloakyl derivatives of imidazo (1,5-a) indol-3-one and process for their preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2143630T3 true ES2143630T3 (en) | 2000-05-16 |
Family
ID=10755671
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95919370T Expired - Lifetime ES2143630T3 (en) | 1994-05-25 | 1995-05-02 | AZABICICLOALKYL DERIVATIVES OF IMIDAZO (1,5-A) INDOL-3-ONA USED AS 5HT3 ANTAGONISTS. |
Country Status (8)
Country | Link |
---|---|
US (1) | US5637596A (en) |
EP (1) | EP0711299B1 (en) |
JP (1) | JP3615550B2 (en) |
CA (1) | CA2166621A1 (en) |
DE (1) | DE69514315T2 (en) |
ES (1) | ES2143630T3 (en) |
GB (1) | GB9410441D0 (en) |
WO (1) | WO1995032209A1 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6054756A (en) | 1992-07-24 | 2000-04-25 | Tessera, Inc. | Connection components with frangible leads and bus |
US20020151111A1 (en) * | 1995-05-08 | 2002-10-17 | Tessera, Inc. | P-connection components with frangible leads and bus |
JP2002518331A (en) * | 1998-06-19 | 2002-06-25 | イーライ・リリー・アンド・カンパニー | Inhibition of serotonin reuptake |
IT1303123B1 (en) * | 1998-10-13 | 2000-10-30 | Rotta Research Lab | BASIC DERIVATIVES OF BENZ (E) ISOINDOL-1-ONI AND PIRROLE (3,4-C) CHINOLIN-1-ONI WITH ACTIVITY 5HT3 ANTAGONIST, THEIR PREPARATION AND |
FR2797630B1 (en) * | 1999-08-20 | 2005-04-29 | Univ Caen Basse Normandie | PYRROLO [1,2-a] QUINOXALINE ETHER DERIVATIVES, PROCESS FOR PREPARING THEM AND THEIR THERAPEUTIC APPLICATION |
US8697722B2 (en) * | 2007-11-02 | 2014-04-15 | Sri International | Nicotinic acetylcholine receptor modulators |
EP2523562B1 (en) * | 2010-01-11 | 2019-01-02 | Astraea Therapeutics, LLC | Nicotinic acetylcholine receptor modulators |
CN113582999A (en) * | 2021-07-09 | 2021-11-02 | 成都大学 | Method for preparing imidazo [1,5-a ] indole compound |
CN113583000A (en) * | 2021-07-09 | 2021-11-02 | 成都大学 | Method for preparing imidazo [1,5-a ] indol-3-one |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3565902A (en) * | 1967-09-15 | 1971-02-23 | American Cyanamid Co | 1,2-dihydro-3h-imidazo(1,5-a)indol-3-ones and 3-thiones |
GB9106571D0 (en) * | 1991-03-27 | 1991-05-15 | Erba Carlo Spa | Derivatives of substituted imidazol-2-one and process for their preparation |
GB9201749D0 (en) * | 1992-01-28 | 1992-03-11 | Smithkline Beecham Plc | Medicaments |
GB9212486D0 (en) * | 1992-06-12 | 1992-07-22 | Erba Carlo Spa | Derivatives of substituted imidazo benzoxazin-1-one and process for their preparation |
-
1994
- 1994-05-25 GB GB9410441A patent/GB9410441D0/en active Pending
-
1995
- 1995-05-02 US US08/578,548 patent/US5637596A/en not_active Expired - Fee Related
- 1995-05-02 CA CA002166621A patent/CA2166621A1/en not_active Abandoned
- 1995-05-02 EP EP95919370A patent/EP0711299B1/en not_active Expired - Lifetime
- 1995-05-02 DE DE69514315T patent/DE69514315T2/en not_active Expired - Fee Related
- 1995-05-02 JP JP53001095A patent/JP3615550B2/en not_active Expired - Fee Related
- 1995-05-02 ES ES95919370T patent/ES2143630T3/en not_active Expired - Lifetime
- 1995-05-02 WO PCT/EP1995/001652 patent/WO1995032209A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
DE69514315T2 (en) | 2000-07-27 |
DE69514315D1 (en) | 2000-02-10 |
WO1995032209A1 (en) | 1995-11-30 |
EP0711299B1 (en) | 2000-01-05 |
US5637596A (en) | 1997-06-10 |
JP3615550B2 (en) | 2005-02-02 |
JPH09500913A (en) | 1997-01-28 |
CA2166621A1 (en) | 1995-11-30 |
GB9410441D0 (en) | 1994-07-13 |
EP0711299A1 (en) | 1996-05-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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