FI883897A - ETT FOERBAETTRAT FOERFARANDE FOER FRAMSTAELLNING AV ETT FARMACEUTISKT ANVAENDBART AEMNE. - Google Patents
ETT FOERBAETTRAT FOERFARANDE FOER FRAMSTAELLNING AV ETT FARMACEUTISKT ANVAENDBART AEMNE. Download PDFInfo
- Publication number
- FI883897A FI883897A FI883897A FI883897A FI883897A FI 883897 A FI883897 A FI 883897A FI 883897 A FI883897 A FI 883897A FI 883897 A FI883897 A FI 883897A FI 883897 A FI883897 A FI 883897A
- Authority
- FI
- Finland
- Prior art keywords
- ett
- cromoglicate
- bis
- disodium salt
- reaction mixture
- Prior art date
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to an improved process for preparing a disodium salt of 5,5'-[(2-hydroxy-1,3- propanediyl)bis](oxy)bis[4-oxo-4H-1-benzopyran-2- carboxylic acid], or disodium salt of cromoglicate, which is used as an asthma drug, by hydrolysing the diethyl ester of 5,5'-[(2-hydroxy-1,3-propanediyl)bis(oxy)]bis[4- oxo-4H-1-benzopyran-2-carboxylic acid] with the aid of diethylamine, triethylamine or tert-butylamine in a 70- 80% aqueous solution of dimethylformamide, methanol or ethanol by means of boiling the reaction mixture under reflux for 2-8 h. The ammonium salt of cromoglicate, which is thereby formed and which is readily soluble in the reaction mixture, is reacted, after treatment with active charcoal and filtering, with sodium acetate, in association with which the disodium salt of cromoglicate precipitates out. After the reaction mixture has been cooled to approx. 15 degree C, the pure disodium salt of cromoglicate is recovered by filtration.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI883897A FI83311C (en) | 1988-08-24 | 1988-08-24 | An improved process for the preparation of a therapeutic action with sodium salt of 5,5 '- / (2-hydroxy-1,3-propandinyl) bis (oxy) / bis / 4-oxo-4H-1-benzopyran-2-carboxylic acid disodium salt |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI883897 | 1988-08-24 | ||
| FI883897A FI83311C (en) | 1988-08-24 | 1988-08-24 | An improved process for the preparation of a therapeutic action with sodium salt of 5,5 '- / (2-hydroxy-1,3-propandinyl) bis (oxy) / bis / 4-oxo-4H-1-benzopyran-2-carboxylic acid disodium salt |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI883897A0 FI883897A0 (en) | 1988-08-24 |
| FI883897A true FI883897A (en) | 1990-02-25 |
| FI83311B FI83311B (en) | 1991-03-15 |
| FI83311C FI83311C (en) | 1991-06-25 |
Family
ID=8526946
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI883897A FI83311C (en) | 1988-08-24 | 1988-08-24 | An improved process for the preparation of a therapeutic action with sodium salt of 5,5 '- / (2-hydroxy-1,3-propandinyl) bis (oxy) / bis / 4-oxo-4H-1-benzopyran-2-carboxylic acid disodium salt |
Country Status (1)
| Country | Link |
|---|---|
| FI (1) | FI83311C (en) |
-
1988
- 1988-08-24 FI FI883897A patent/FI83311C/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| FI83311C (en) | 1991-06-25 |
| FI883897A0 (en) | 1988-08-24 |
| FI83311B (en) | 1991-03-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: ORION-YHTYMAE OY FERMION |