FI883207A0 - FOERFARANDE FOER FRAMSTAELLNING AV AMINOMETYLENFOSFONOALKYLFOSFINATER. - Google Patents

FOERFARANDE FOER FRAMSTAELLNING AV AMINOMETYLENFOSFONOALKYLFOSFINATER.

Info

Publication number
FI883207A0
FI883207A0 FI883207A FI883207A FI883207A0 FI 883207 A0 FI883207 A0 FI 883207A0 FI 883207 A FI883207 A FI 883207A FI 883207 A FI883207 A FI 883207A FI 883207 A0 FI883207 A0 FI 883207A0
Authority
FI
Finland
Prior art keywords
aminometylenfosfonoalkylfosfinater
foerfarande foer
foer framstaellning
ester
mixture
Prior art date
Application number
FI883207A
Other languages
Finnish (fi)
Other versions
FI88721C (en
FI883207A (en
FI88721B (en
Inventor
Frank Hallock Ebetino
Original Assignee
Norwich Eaton Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Norwich Eaton Pharma filed Critical Norwich Eaton Pharma
Publication of FI883207A0 publication Critical patent/FI883207A0/en
Publication of FI883207A publication Critical patent/FI883207A/en
Application granted granted Critical
Publication of FI88721B publication Critical patent/FI88721B/en
Publication of FI88721C publication Critical patent/FI88721C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C07F9/3821—Acyclic saturated acids which can have further substituents on alkyl substituted by B, Si, P or a metal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/59—Hydrogenated pyridine rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Luminescent Compositions (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention involves processes for making aminomethylene phosphonoalkylphosphinate compounds comprising: (a) heating a substantially anhydrous mixture comprising an amine, an ester of an alkyl phosphite, and an ester of a phosphate acetyl; and then (b) adding water to the mixture. s
FI883207A 1987-07-06 1988-07-05 Process for the preparation of aminomethylene phosphonoalkylphosphinates FI88721C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/069,663 US4963681A (en) 1987-07-06 1987-07-06 Process for synthesis of aminomethylene phosphonoalkylphosphinates
US6966387 1987-07-06

Publications (4)

Publication Number Publication Date
FI883207A0 true FI883207A0 (en) 1988-07-05
FI883207A FI883207A (en) 1989-01-07
FI88721B FI88721B (en) 1993-03-15
FI88721C FI88721C (en) 1993-06-28

Family

ID=22090440

Family Applications (1)

Application Number Title Priority Date Filing Date
FI883207A FI88721C (en) 1987-07-06 1988-07-05 Process for the preparation of aminomethylene phosphonoalkylphosphinates

Country Status (23)

Country Link
US (1) US4963681A (en)
EP (1) EP0298555B1 (en)
JP (1) JPS6485985A (en)
KR (1) KR960008094B1 (en)
AT (1) ATE67500T1 (en)
AU (1) AU607781B2 (en)
CA (1) CA1322077C (en)
DE (1) DE3864927D1 (en)
DK (1) DK375688A (en)
EG (1) EG18559A (en)
ES (1) ES2029875T3 (en)
FI (1) FI88721C (en)
GR (1) GR3002741T3 (en)
HK (1) HK54294A (en)
IE (1) IE60912B1 (en)
IL (1) IL86952A (en)
MX (1) MX171302B (en)
MY (1) MY106953A (en)
NO (1) NO176479C (en)
NZ (1) NZ225273A (en)
PH (1) PH25817A (en)
PT (1) PT87916B (en)
ZA (1) ZA884793B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8825589D0 (en) * 1988-11-02 1988-12-07 Albright & Wilson Purification
US5562894A (en) * 1991-08-09 1996-10-08 Regents Of The University Of California Amino-acyl-type and catecholamine-type contrast agents for MRI
DE69216514T2 (en) * 1991-08-27 1997-07-31 Ciba Geigy Ag N-substituted aminomethane diphosphonic acids
US5278153A (en) * 1992-05-18 1994-01-11 E. R. Squibb & Sons, Inc. Aryl and heteroaryl (phosphinylmethyl)phosphonate squalene synthetase inhibitors and method
KR101142811B1 (en) 2007-11-27 2012-05-08 하리마 카세이 가부시키가이샤 Flux for soldering, soldering paste composition, and method of soldering
KR101133960B1 (en) 2007-11-27 2012-04-05 하리마 카세이 가부시키가이샤 Flux for soldering and soldering paste composition
GB201200868D0 (en) 2012-01-19 2012-02-29 Depuy Int Ltd Bone filler composition

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3553314A (en) * 1968-12-23 1971-01-05 Procter & Gamble Oral compositions for calculus retardation
DE1958123C3 (en) * 1969-11-19 1978-09-28 Henkel Kgaa, 4000 Duesseldorf Process for the preparation of 1-aminoalkane-1,1-diphosphonic acids or their salts
US3979385A (en) * 1969-11-19 1976-09-07 Henkel & Cie G.M.B.H. 1-Aminoalkane-1,1-diphosphonic acids and their salts
US3683080A (en) * 1970-08-28 1972-08-08 Procter & Gamble Compositions for inhibiting anomalous deposition and mobilization of calcium phosphate in animal tissue
US3899496A (en) * 1970-10-06 1975-08-12 Henkel & Cie Gmbh Production of 1-aminoalkane-1,1-diphosphonic acids
DE2104476C2 (en) * 1971-02-01 1983-12-01 Henkel KGaA, 4000 Düsseldorf Process for preventing precipitation in water or aqueous solutions
DE2343196C3 (en) * 1973-08-27 1980-01-10 Henkel Kgaa, 4000 Duesseldorf Aiacycloalkan-2 ^ -diphosphonic acids or their water-soluble salts
US3988443A (en) * 1973-08-27 1976-10-26 Henkel & Cie G.M.B.H. Azacycloalkane-2,2-diphosphonic acids
DE2360798A1 (en) * 1973-12-06 1975-06-26 Henkel & Cie Gmbh Calcium deposition influencing pharmaceutical/cosmetic prepns. - contg. polymethylenephosphonic acid cpds.
US4134969A (en) * 1974-02-04 1979-01-16 Henkel Kommanditgesellschaft Auf Aktien (Henkel Kgaa) Method of treatment of calcium disorders using aminoalkane-diphosphonic acids
DE2456666A1 (en) * 1974-11-30 1976-08-12 Henkel & Cie Gmbh METHOD OF STABILIZING CALCIUM HYDROGEN PHOSPHATE DIHYDRATE AGAINST HYDROLYSIS
US4113861A (en) * 1977-05-02 1978-09-12 The Procter & Gamble Company Phosphonate pharmaceutical composition
DE2745083C2 (en) * 1977-10-07 1985-05-02 Henkel KGaA, 4000 Düsseldorf Hydroxydiphosphonic acids and processes for their preparation
IL61985A0 (en) * 1980-02-01 1981-02-27 Sparamedica Ag Phosphinic and phosphonic acid derivatives,their manufacture and pharmaceutical compositions containing them
DE3016289A1 (en) * 1980-04-28 1981-10-29 Henkel KGaA, 4000 Düsseldorf METHOD FOR PRODUCING OMEGA-AMINO-1-HYDROXYALKYLIDEN-1,1-BIS-PHOSPHONIC ACIDS
US4304734A (en) * 1980-10-16 1981-12-08 Vysoka Skola Chemicko-Technologicka 6-Amino-1-hydroxyhexylidene diphosphonic acid, salts and a process for production thereof
IT1201087B (en) * 1982-04-15 1989-01-27 Gentili Ist Spa PHARMACOLOGICALLY ACTIVE BIPPHOSPHONES, PROCEDURE FOR THEIR PREPARATION AND RELATED PHARMACEUTICAL COMPOSITIONS
DE3425812A1 (en) * 1984-07-13 1986-01-16 Deutsches Krebsforschungszentrum, 6900 Heidelberg NEW 1-HYDROXY-1,1-DIPHOSPHONIC ACID COMPOUNDS, PROCESS FOR THEIR PRODUCTION AND PHARMACOLOGICAL PREPARATIONS, IN PARTICULAR FOR THE TREATMENT OF BONE TUMORS
DE3428524A1 (en) * 1984-08-02 1986-02-13 Boehringer Mannheim Gmbh, 6800 Mannheim NEW DIPHOSPHONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
US4639338A (en) * 1984-08-06 1987-01-27 Ciba-Geigy Corporation Preparation of crystalline disodium 3-amino-1-hydroxypropane-1,1-diphosphonate pentahydrate
US4687768A (en) * 1984-12-21 1987-08-18 The Procter & Gamble Company Certain hexahydroindan-2,2-diphosphonic acids useful in treating diseases associated with abnormal calcium and phosphate metabolism
DE3540150A1 (en) * 1985-11-13 1987-05-14 Boehringer Mannheim Gmbh NEW DIPHOSPHONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
US4902679A (en) * 1985-12-13 1990-02-20 Norwich Eaton Pharmaceuticals, Inc. Methods of treating diseases with certain geminal diphosphonates
IL86951A (en) * 1987-07-06 1996-07-23 Procter & Gamble Pharma Methylene phosphonoalkyl-phosphinates and pharmaceutical compositions containing them
US4871721A (en) * 1988-01-11 1989-10-03 E. R. Squibb & Sons, Inc. Phosphorus-containing squalene synthetase inhibitors

Also Published As

Publication number Publication date
IE882051L (en) 1989-01-06
ES2029875T3 (en) 1992-10-01
KR890002208A (en) 1989-04-10
NO176479B (en) 1995-01-02
NO176479C (en) 1995-04-12
GR3002741T3 (en) 1993-01-25
DK375688D0 (en) 1988-07-06
US4963681A (en) 1990-10-16
DK375688A (en) 1989-01-07
FI88721C (en) 1993-06-28
MX171302B (en) 1993-10-18
IL86952A (en) 1993-01-14
FI883207A (en) 1989-01-07
KR960008094B1 (en) 1996-06-19
HK54294A (en) 1994-06-03
PT87916A (en) 1989-06-30
IE60912B1 (en) 1994-08-24
NZ225273A (en) 1991-07-26
PH25817A (en) 1991-11-05
EP0298555A1 (en) 1989-01-11
EG18559A (en) 1993-06-30
IL86952A0 (en) 1988-12-30
ZA884793B (en) 1989-03-29
MY106953A (en) 1995-08-30
CA1322077C (en) 1993-09-07
NO882986L (en) 1989-01-09
DE3864927D1 (en) 1991-10-24
AU607781B2 (en) 1991-03-14
JPS6485985A (en) 1989-03-30
PT87916B (en) 1995-03-01
NO882986D0 (en) 1988-07-05
ATE67500T1 (en) 1991-10-15
EP0298555B1 (en) 1991-09-18
AU1876688A (en) 1989-01-12
FI88721B (en) 1993-03-15

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Legal Events

Date Code Title Description
BB Publication of examined application
MM Patent lapsed

Owner name: NORWICH EATON PHARMACEUTICALS, INC.