FI853818L - METALLISENIUMSALTER OCH DERAS ANVAENDNING SOM CYTOSTATICA VID BEKAEMPANDE AV CANCER. - Google Patents
METALLISENIUMSALTER OCH DERAS ANVAENDNING SOM CYTOSTATICA VID BEKAEMPANDE AV CANCER.Info
- Publication number
- FI853818L FI853818L FI853818A FI853818A FI853818L FI 853818 L FI853818 L FI 853818L FI 853818 A FI853818 A FI 853818A FI 853818 A FI853818 A FI 853818A FI 853818 L FI853818 L FI 853818L
- Authority
- FI
- Finland
- Prior art keywords
- cancer
- metalliseniumsalter
- bekaempande
- cytostatica
- vid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F17/00—Metallocenes
- C07F17/02—Metallocenes of metals of Groups 8, 9 or 10 of the Periodic System
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F17/00—Metallocenes
Abstract
The invention relates to metallicenium salts of the formula (I) <IMAGE> in which M is Fe, Co, Ni, Ru or Os; C5H5-xRx and C5H5-yR'y denote cyclopentadienyl rings which, independently of each other, can be unsubstituted (x, y = 0) or substituted 1-5 times (x, y = 1, 2, 3, 4 or 5), where R and R', independently of each other, represent identical or different substituents and denote alkyl, cycloalkyl, hydroxyalkyl, aminoalkyl, halogenoalkyl, alkenyl, aryl, aralkyl, ferrocenyl, ferrocenylium, ferrocenylalkyl, acyl, halogenyl, trialkylsilyl, tricycloalkylsilyl, triarylsilyl or triaralkylsilyl or carboxyl, ester, amide or hydrazide groups, or R and R' together form an alkylene bridge containing 2-4 bridge atoms; a, b, m and n are integers, where m has the value 1 or 2 and n the value 1, 2 or 3, and a.m = b.n; and A is a complex-forming or highly space-filling anion which stabilizes metallicenium cations; and solvates of these salts for use as medicaments, in particular as cytostatic agents for controlling cancer.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19843404443 DE3404443A1 (en) | 1984-02-08 | 1984-02-08 | METALLICENIUM SALTS AND THEIR USE AS CYTOSTATICA IN CANCER FIGHTING |
DE3404443 | 1984-02-08 | ||
PCT/EP1985/000047 WO1985003507A2 (en) | 1984-02-08 | 1985-02-08 | Metallicenium salts and utilization thereof as cytostatic agents for combatting cancer |
EP8500047 | 1985-02-08 |
Publications (4)
Publication Number | Publication Date |
---|---|
FI853818L true FI853818L (en) | 1985-10-02 |
FI853818A0 FI853818A0 (en) | 1985-10-02 |
FI81358B FI81358B (en) | 1990-06-29 |
FI81358C FI81358C (en) | 1990-10-10 |
Family
ID=6227132
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI853818A FI81358C (en) | 1984-02-08 | 1985-10-02 | FOERFARANDE FOER FRAMSTAELLNING AV FERRICENIUMTRIKLORACETAT-MONO (TRICHLOROETIKSYRA). |
Country Status (8)
Country | Link |
---|---|
US (1) | US4851430A (en) |
EP (1) | EP0153636B1 (en) |
JP (1) | JPH0714877B2 (en) |
AT (1) | ATE48430T1 (en) |
DE (2) | DE3404443A1 (en) |
DK (1) | DK456585A (en) |
FI (1) | FI81358C (en) |
WO (1) | WO1985003507A2 (en) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5049557A (en) * | 1986-05-13 | 1991-09-17 | Chai-Tech Corporation | Metallo-organic salt compounds and pharmaceutical uses thereof |
US5258403A (en) * | 1986-05-13 | 1993-11-02 | Chai-Tech Corporation | Metallo-organic salt compounds and pharmaceutical uses thereof |
IL82376A (en) * | 1986-05-13 | 1991-06-10 | Chai Tech Corp | Pharmaceutical composition for the treatment of inflammatory conditions |
DE3923270A1 (en) * | 1989-07-14 | 1991-01-17 | Medac Klinische Spezialpraep | WATER-SOLUBLE PHARMACEUTICAL METALLOCEN COMPLEX COMPOSITION |
DE4135291A1 (en) * | 1991-10-25 | 1993-04-29 | Koepf Maier Petra | Use of ionic metallocene complexes - as cytostatic agents to treat tumours, esp. solid tumours of lung, breast, gastrointestinal, neck and head |
DE69322225T2 (en) * | 1992-09-22 | 1999-05-12 | Idemitsu Kosan Co | Polymerization catalysts and processes for the production of polymers |
US5863911A (en) * | 1994-10-12 | 1999-01-26 | Modelisation Et Mise Au Point De Molecules Medicinales | Diarylethylene metallocene derivatives, their processes of preparation and pharmaceutical compositions containing said derivatives |
FR2725720B1 (en) * | 1994-10-12 | 1997-01-03 | Modelisation Et Mise Au Point | METALLOCENIC DIARYLETHYLENE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES |
DE19505960A1 (en) * | 1995-02-21 | 1996-08-22 | Deutsches Krebsforsch | Conjugate for the individual dosage of drugs |
US5595763A (en) * | 1995-07-19 | 1997-01-21 | Quimica Farmaceutica Bayer S.A. | Tungsten (VI) compositions for the oral treatment of diabetes mellitus |
US6255507B1 (en) | 1998-09-18 | 2001-07-03 | 3M Innovative Properties Company | Process for preparing cyclopentadienyliron (II) arene complex |
GB9929353D0 (en) | 1999-12-13 | 2000-02-02 | Univ Leeds | Metallocene synthesis |
GB0215593D0 (en) * | 2002-07-05 | 2002-08-14 | Univ Leeds | New anticancer drugs |
DE102008004100A1 (en) | 2008-01-11 | 2009-07-16 | Westfälische Wilhelms-Universität Münster Körperschaft des öffentlichen Rechts | New metallocene compounds are estrogen receptor modulators useful e.g. to treat preferably cancer, manic disorder, gynecomastia and/or female infertility, and to prevent mamma carcinoma |
EP2368895A1 (en) * | 2010-03-03 | 2011-09-28 | Centre National de la Recherche Scientifique (CNRS) | Ferrocenyl flavonoids |
CN106995471B (en) * | 2017-04-17 | 2019-06-28 | 陕西师范大学 | Ferricinum ion salt containing energy and preparation method thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL46027A (en) * | 1973-11-21 | 1977-06-30 | Fisons Ltd | Organo-metallic compounds their preparation and pharmaceutical compositions containing them |
DE2623486C2 (en) * | 1976-05-26 | 1982-12-30 | Hoechst Ag, 6000 Frankfurt | 3.5.5-Trimethylhexanoylferrocene, process for its preparation and pharmaceutical preparations |
DE2623487A1 (en) * | 1976-05-26 | 1977-12-15 | Hoechst Ag | FERROCEN DERIVATIVES AND THE PROCESS FOR THEIR PRODUCTION |
DE2923334C2 (en) * | 1979-06-08 | 1985-03-07 | Hartmut Prof. Dipl.-Chem. Dr. Köpf | Use of cyclopentadienyl metal-acido complexes in the fight against cancer and medicinal preparations containing these complexes |
-
1984
- 1984-02-08 DE DE19843404443 patent/DE3404443A1/en not_active Withdrawn
-
1985
- 1985-02-08 DE DE8585101370T patent/DE3574596D1/en not_active Expired - Fee Related
- 1985-02-08 AT AT85101370T patent/ATE48430T1/en not_active IP Right Cessation
- 1985-02-08 US US06/784,291 patent/US4851430A/en not_active Expired - Fee Related
- 1985-02-08 JP JP60501069A patent/JPH0714877B2/en not_active Expired - Lifetime
- 1985-02-08 WO PCT/EP1985/000047 patent/WO1985003507A2/en active IP Right Grant
- 1985-02-08 EP EP85101370A patent/EP0153636B1/en not_active Expired
- 1985-10-02 FI FI853818A patent/FI81358C/en not_active IP Right Cessation
- 1985-10-07 DK DK456585A patent/DK456585A/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP0153636A2 (en) | 1985-09-04 |
JPS61501092A (en) | 1986-05-29 |
FI81358C (en) | 1990-10-10 |
DE3574596D1 (en) | 1990-01-11 |
JPH0714877B2 (en) | 1995-02-22 |
DK456585D0 (en) | 1985-10-07 |
WO1985003507A2 (en) | 1985-08-15 |
EP0153636B1 (en) | 1989-12-06 |
ATE48430T1 (en) | 1989-12-15 |
FI81358B (en) | 1990-06-29 |
WO1985003507A3 (en) | 1985-09-26 |
DK456585A (en) | 1985-10-07 |
US4851430A (en) | 1989-07-25 |
EP0153636A3 (en) | 1985-11-06 |
FI853818A0 (en) | 1985-10-02 |
DE3404443A1 (en) | 1985-08-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM | Patent lapsed | ||
MM | Patent lapsed |
Owner name: KOEPF-MAIER, PETRA Owner name: NEUSE, EBERHARD WILHELM Owner name: KOEPF, HARTMUT |