FI824238A0 - Foerfarande och vektororganism foer ackumulering av klonade heterologa genprodukter reglerat i bacillus subtilis ii - Google Patents

Foerfarande och vektororganism foer ackumulering av klonade heterologa genprodukter reglerat i bacillus subtilis ii

Info

Publication number
FI824238A0
FI824238A0 FI824238A FI824238A FI824238A0 FI 824238 A0 FI824238 A0 FI 824238A0 FI 824238 A FI824238 A FI 824238A FI 824238 A FI824238 A FI 824238A FI 824238 A0 FI824238 A0 FI 824238A0
Authority
FI
Finland
Prior art keywords
heterologous gene
subtilis
reglerat
genprodukter
clonade
Prior art date
Application number
FI824238A
Other languages
English (en)
Finnish (fi)
Other versions
FI824238L (fi
Inventor
Shing Chang
Original Assignee
Cetus Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cetus Corp filed Critical Cetus Corp
Publication of FI824238A0 publication Critical patent/FI824238A0/fi
Publication of FI824238L publication Critical patent/FI824238L/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/75—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Bacillus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
FI824238A 1981-04-20 1982-12-09 Foerfarande och vektororganism foer ackumulering av klonade heterologa genprodukter reglerat i bacillus subtilis ii FI824238L (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25580481A 1981-04-20 1981-04-20
PCT/US1982/000490 WO1982003633A1 (en) 1981-04-20 1982-04-20 Method and vector organism for controlled accumulation of cloned heterologous gene products in bacillus subtilis

Publications (2)

Publication Number Publication Date
FI824238A0 true FI824238A0 (fi) 1982-12-09
FI824238L FI824238L (fi) 1982-12-09

Family

ID=22969947

Family Applications (1)

Application Number Title Priority Date Filing Date
FI824238A FI824238L (fi) 1981-04-20 1982-12-09 Foerfarande och vektororganism foer ackumulering av klonade heterologa genprodukter reglerat i bacillus subtilis ii

Country Status (12)

Country Link
EP (1) EP0063494B1 (de)
JP (1) JPS58500590A (de)
AT (1) ATE48639T1 (de)
AU (1) AU551529B2 (de)
CA (1) CA1204681A (de)
DE (1) DE3280060D1 (de)
DK (1) DK563082A (de)
ES (2) ES8308586A1 (de)
FI (1) FI824238L (de)
IL (1) IL65558A0 (de)
NO (1) NO824102L (de)
WO (1) WO1982003633A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR8202422A (pt) * 1981-04-29 1983-04-12 Biogen Nv Vetor de clonacao de bacillus processo para sua construcao molecula de dna recombinante processo para sua construcao e processo para a producao de um polipeptidio
US4559300A (en) * 1983-01-18 1985-12-17 Eli Lilly And Company Method for using an homologous bacillus promoter and associated natural or modified ribosome binding site-containing DNA sequence in streptomyces
GR81701B (de) * 1983-01-18 1984-12-12 Lilly Co Eli
US4595660A (en) * 1983-03-02 1986-06-17 University Of Delaware Molecular cloning with bifunctional plasmid vectors in Bacillus subtilis, mutants and substantially stably transformed mutants of Bacillus subtilis, and methods for utilizing the transformed mutants
US4585739A (en) * 1983-03-07 1986-04-29 E. I. Du Pont De Nemours And Company Plasmid for foreign gene expression in B. subtilis
US4663280A (en) * 1983-05-19 1987-05-05 Public Health Research Institute Of The City Of New York Expression and secretion vectors and method of constructing vectors
US5310675A (en) * 1983-06-24 1994-05-10 Genencor, Inc. Procaryotic carbonyl hydrolases
JPS60137291A (ja) * 1983-12-26 1985-07-20 Takeda Chem Ind Ltd 発現ベクター
US4769327A (en) * 1985-03-29 1988-09-06 Biotechnica International, Inc. Secretion vector
IT1186750B (it) * 1985-07-10 1987-12-16 Eniricerche Spa Vettore di clonaggio,molecole di dna ricombinante,ceppi di bacillus subtilis trasformati con dette molecole e metodi per l'espressione di geni eterologhi e produzione e secrezione di proteine codificate da detti geni

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2961658D1 (en) * 1978-05-17 1982-02-18 Thomae Gmbh Dr K Process for preparing human interferon
JPS5564799A (en) * 1978-11-07 1980-05-15 Toray Ind Inc Multi-stage concentration and purification of interferon originated from human fibroblast
NL8000127A (nl) * 1979-01-15 1980-07-17 Harvard College Werkwijze voor het vormen van prokaryotische of eukaryotische proteinen alsmede een daarbij toepasbaar gekoppeld gen.
US4311639A (en) * 1980-07-25 1982-01-19 E. I. Du Pont De Nemours And Company Immunogenic interferon peptides

Also Published As

Publication number Publication date
ATE48639T1 (de) 1989-12-15
DE3280060D1 (de) 1990-01-18
ES511510A0 (es) 1983-09-16
WO1982003633A1 (en) 1982-10-28
AU8521382A (en) 1982-11-04
ES519234A0 (es) 1984-03-01
IL65558A0 (en) 1982-07-30
FI824238L (fi) 1982-12-09
JPS58500590A (ja) 1983-04-21
NO824102L (no) 1982-12-07
CA1204681A (en) 1986-05-20
EP0063494B1 (de) 1989-12-13
ES8308586A1 (es) 1983-09-16
EP0063494A3 (en) 1984-02-22
AU551529B2 (en) 1986-05-01
EP0063494A2 (de) 1982-10-27
DK563082A (da) 1982-12-20
ES8403158A1 (es) 1984-03-01

Similar Documents

Publication Publication Date Title
ES8306796A1 (es) "un metodo de crear un microorganismo capaz de producir una proteina predeterminada por expresion".
Doi et al. Potential use of Bacillus subtilis for secretion and production of foreign proteins
ES8305045A1 (es) "un procedimiento para obtener una proteina cristalina de b. thuringiensis".
FI871919A (fi) Sekretionssignalselektionsvektorer foer extracellulaer proteinsyntes hos bacillus-bakterier.
FI824238L (fi) Foerfarande och vektororganism foer ackumulering av klonade heterologa genprodukter reglerat i bacillus subtilis ii
DE3584053D1 (de) Gentechnologisches verfahren zur herstellung von hirudinen und mittel zur durchfuehrung dieses verfahrens.
FI884691A (fi) Lysostafiinia koodittava DNA-fragmentti, sitä sisältävä yhdistelmäplasmidi ja transformoitu bakteeri sekä menetelmä lysostafiiniaktiivisuuden omaavan tuotteen valmistamiseksi
ZA919965B (en) Cloning and expression of borrelia lipoproteins
KR880010126A (ko) 펙틴 라이에이즈 발현 시스템을 암호화하는 dna 서열을 함유하는 재조합 dna 분자 및 이의 제조방법
WO1989007144A3 (en) High yield protein production system
DK0677110T4 (da) Rekombinant mælkesyrebakterie, der indeholder en inserteret promotor
IT1208514B (it) Vettori plasmidici ad espressione in escherichia coli e/o bacillussubtilis.
EP0164992A3 (de) Regulierende Gene für die Stickstoffixierung
HUT40697A (en) Expression vectors containing p down l promotor, presumed restriction places for the substitution of ribosomal bonding places, plasmides containing the vectors, host organisms containing the plasmides and methods relating thereto
CA1314010C (en) Method to export gene products to the growth medium of gram negative bacteria
KALLIO et al. Synthesis of OmpA protein of Escherichia coli K12 in Bacillus subtilis
Vasantha et al. Fusion of pro region of subtilisin to staphylococcal protein A and its secretion by Bacillus subtilis
SE8100241L (sv) Mikrobiologiskt framstelld polypeptid med samma aminosyrasekvens som hos proinsulinet av primater, dna och plasmider, vilka kodierar for denna sekvens mikroorganismer, som innehaller dessa genetiska informationer, ...
Yang et al. Effects of amino acid insertions on the proteolysis of a staphylococcal protein A derivative in Escherichia coli
ATE195143T1 (de) Verwendung von autologen promotoren zur expression von genprodukten in bordetella
EP0467676A2 (de) Temperatur-induzierbare Sekretions-, Expressionsvektoren und ihre Verwendung in prokaryotischen Zellen
East et al. Change of a single amino acid in the leader peptide of a staphylococcal β-lactamase prevents the appearance of the enzyme in the medium
Oudega et al. A lipoprotein signal peptide plus a cysteine residue at the amino-terminal end of the periplasmic protein β-lactamase is sufficient for its lipid modification, processing and membrane localization in Escherichia coli
IT1231016B (it) Espressione termoinducibile di geni eterologhi in bacillus subtilis e mezzi e metodi per il suo ottenimento
Greenfield Diphtheria Toxin Expression in Escherichia coli

Legal Events

Date Code Title Description
FD Application lapsed

Owner name: CETUS CORPORATION