FI821132L - NYA BENSO / B / TIOFENER, BENSO / B / FURANER, TIOKROMANER OCH KROMANER MED ANTIMIKROB AKTIVITET - Google Patents

Abstract

Compounds whose formula is I, <IMAGE> where n is 0 or a whole number 1-4; p is 0 or 1; q is 0, 1 or 2, R1 and R2 are independently of each other hydrogen or halogen atoms or lower alkyl, lower halogenalkyl, nitro or NR2R3 groups, where R2 and R3 are independently of each other hydrogen atoms or lower alkyl groups; or R and R1 in adjacent positions form a fused saturated or unsaturated carbocyclic ring which can contain 5-7 carbon atoms; X is an acid or a sulphur atom, or a sulphinyl or sulphonyl group; Y is an imidazolyl or 1,2,4-triazolyl group, both of which can be substituted with a lower alkyl or aryl group, where said aryl group is a phenyl, halogenphenyl or lower alkylphenyl group; Z is an alkyl, alkenyl, alkynyl, cycloalkyl or heterocyclic aromatic group, in which there can be at least 1 substituent chosen from halogen atoms and from lower alkyl, lower alkoxy, lower alkylidenedioxy, phenyl and N-(N'-lower alkanoylpiperazinyl) groups, provided that, where n is 0, Z is not 1-alkynyl, and where n is 1-4, Z can also be an alkoxy, alkylthio, aryl, aryloxy or arylthio group, or aryl, aryloxy or arylthio group containing substituents chosen from halogen atoms and lower alkyl, lower alkoxy, lower alkylidenedioxy and N- (N'-lower alkanoylpiperazinyl) groups, where the designation "lower" refers to groups with 1-6 carbon atoms; and the broken line refers to a single bond or a double bond, provided that it is a double bond only when p is 0 and X is a sulphur atom; and the acid addition salts thereof have an antimicrobial, particularly antifungal, antibacterial and antiprotozoal activity. The invention also relates to mixtures, particularly pharmaceutical mixtures which contain these compounds, as well as the method for production thereof.