SE8404712L - AZOLD DERIVATIVES, PROCEDURES FOR THEIR PREPARATION, COMPOSITIONS CONTAINING THEM AND THEIR USE - Google Patents

AZOLD DERIVATIVES, PROCEDURES FOR THEIR PREPARATION, COMPOSITIONS CONTAINING THEM AND THEIR USE

Info

Publication number
SE8404712L
SE8404712L SE8404712A SE8404712A SE8404712L SE 8404712 L SE8404712 L SE 8404712L SE 8404712 A SE8404712 A SE 8404712A SE 8404712 A SE8404712 A SE 8404712A SE 8404712 L SE8404712 L SE 8404712L
Authority
SE
Sweden
Prior art keywords
hydrogen
halogen
azold
procedures
derivatives
Prior art date
Application number
SE8404712A
Other languages
Swedish (sv)
Other versions
SE8404712D0 (en
Inventor
H Egger
Original Assignee
Sandoz Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ltd filed Critical Sandoz Ltd
Publication of SE8404712D0 publication Critical patent/SE8404712D0/en
Publication of SE8404712L publication Critical patent/SE8404712L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/50—1,3-Diazoles; Hydrogenated 1,3-diazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647—Triazoles; Hydrogenated triazoles
    • A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/08—Compounds containing oxirane rings with hydrocarbon radicals, substituted by halogen atoms, nitro radicals or nitroso radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A compound of formula I <IMAGE> wherein R1 and R2, independently, are hydrogen, halogen, nitro; or unsubstituted or mono- or poly-halogen substituted lower alkyl, lower alkenyl, lower alkynyl, lower alkoxy or lower alkylthio; or unsubstituted or substituted phenyl or phenoxy, R3 is hydrogen or lower alkyl, R4 and R5, independently, are hydrogen or halogen, Y is CH or N, A is a C2-7methylene bridge and n is 0 or 1, in free base form or in the form of an acid addition salt or a physiologically-hydrolysable and -acceptable derivative, which compounds are indicated for use as chemotherapeutic agents e.g. as anti-mycotics and in addition as fungicides.
SE8404712A 1983-09-22 1984-09-20 AZOLD DERIVATIVES, PROCEDURES FOR THEIR PREPARATION, COMPOSITIONS CONTAINING THEM AND THEIR USE SE8404712L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH515683 1983-09-22
CH634983 1983-11-28

Publications (2)

Publication Number Publication Date
SE8404712D0 SE8404712D0 (en) 1984-09-20
SE8404712L true SE8404712L (en) 1985-03-23

Family

ID=25697104

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8404712A SE8404712L (en) 1983-09-22 1984-09-20 AZOLD DERIVATIVES, PROCEDURES FOR THEIR PREPARATION, COMPOSITIONS CONTAINING THEM AND THEIR USE

Country Status (14)

Country Link
AU (1) AU3339884A (en)
BE (1) BE900594A (en)
DE (1) DE3433553A1 (en)
DK (1) DK450784A (en)
ES (1) ES8601146A1 (en)
FI (1) FI843692L (en)
FR (1) FR2552431A1 (en)
GB (1) GB2146987A (en)
IL (1) IL73008A0 (en)
IT (1) IT1199193B (en)
LU (1) LU85551A1 (en)
NL (1) NL8402755A (en)
PT (1) PT79240B (en)
SE (1) SE8404712L (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8429932D0 (en) * 1984-11-27 1985-01-03 Pfizer Ltd Triazole antifungal agents
DE3608792A1 (en) * 1986-03-15 1987-09-24 Hoechst Ag 1,1-DISUBSTITUTED CYCLOPROPANE DERIVATIVES, METHOD FOR THEIR PRODUCTION AND THEIR USE
US5084465A (en) * 1986-06-23 1992-01-28 Du Pont Merck Pharmaceutical Company Antifungal carbinols
US4952232A (en) * 1987-04-29 1990-08-28 E. I. Du Pont De Nemours And Company Antifungal carbinols
US4965281A (en) * 1986-06-23 1990-10-23 E. I. Du Pont De Nemours And Cmopany Antifungal carbinols
DE3784787T2 (en) * 1986-06-23 1994-01-20 Du Pont Merck Pharma Fungicidal carbinols.
US4980367A (en) * 1987-12-17 1990-12-25 E. I. Du Pont De Nemours And Company Antifungal carbinols
DE3644615A1 (en) * 1986-12-29 1988-07-07 Lentia Gmbh IMIDAZOLE AND TRIAZOLE DERIVATIVES FOR USE AS AN ANTIMYCOTIC AGENTS
US5268517A (en) * 1989-07-14 1993-12-07 Basf Aktiengesellschaft Stereoselective preparation of Z-1,2-diarylallyl chlorides and the conversion thereof into azolylmethyloxiranes, and novel intermediates
JP2975058B2 (en) * 1989-07-18 1999-11-10 ビーエーエスエフ アクチェンゲゼルシャフト Novel Z-1,2-diaryl-allyl chloride, method for its configuration-selective preparation and novel chloromethyl-diaryl-oxirane prepared therefrom
US6960581B2 (en) 2002-01-14 2005-11-01 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical formulations, and uses thereof
PT1490062E (en) 2002-03-26 2008-01-30 Boehringer Ingelheim Pharma Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
CA2477764A1 (en) 2002-03-26 2003-10-09 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
US7186864B2 (en) 2002-05-29 2007-03-06 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
US7074806B2 (en) 2002-06-06 2006-07-11 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
ATE403648T1 (en) 2002-08-21 2008-08-15 Boehringer Ingelheim Pharma SUBSTITUTED DIHYDROCINOLINES AS GLUCOCORTICOID MIMMETICS, METHOD FOR THE PRODUCTION THEREOF, PHARMACEUTICAL PREPARATIONS AND THEIR USE
CA2512257A1 (en) 2003-01-03 2004-07-29 Boehringer Ingelheim Pharmaceuticals, Inc. 1-propanol and 1-propylamine derivatives and their use as glucocorticoid ligands
UY28526A1 (en) 2003-09-24 2005-04-29 Boehringer Ingelheim Pharma GLUCOCORTICOID MIMETICS, METHODS OF PREPARATION PHARMACEUTICAL COMPOSITIONS AND USES OF THE SAME
ATE366726T1 (en) 2003-10-16 2007-08-15 Boehringer Ingelheim Pharma STEREOSELECTIVE SYNTHESIS OF CERTAIN TRIFLUOROMETHYL-SUBSTITUTED ALCOHOLS
US7795272B2 (en) 2004-03-13 2010-09-14 Boehringer Ingelheim Pharmaceutical, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof
EP1836166B1 (en) 2004-12-27 2009-06-17 Boehringer Ingelheim Pharmaceuticals Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
BRPI0720131A2 (en) 2006-12-06 2014-02-04 Boehringer Ingelheim Int MIMETIC GLYCORTICOIDS, METHODS FOR MAKING THEM, PHARMACEUTICAL COMPOSITIONS AND USES OF THE SAME.
WO2009149139A1 (en) 2008-06-06 2009-12-10 Boehringer Ingelheim International Gmbh Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
US20090312558A1 (en) * 2008-06-13 2009-12-17 Reliance Life Sciences Pvt. Ltd. Process for the preparation of arylcyclopropoane carboxylic carbonitriles, and compounds derived therefrom

Also Published As

Publication number Publication date
GB8423710D0 (en) 1984-10-24
IT1199193B (en) 1988-12-30
DK450784D0 (en) 1984-09-20
FR2552431A1 (en) 1985-03-29
ES536138A0 (en) 1985-11-01
BE900594A (en) 1985-03-18
DE3433553A1 (en) 1985-04-11
PT79240A (en) 1984-10-01
SE8404712D0 (en) 1984-09-20
GB2146987A (en) 1985-05-01
AU3339884A (en) 1985-03-28
PT79240B (en) 1986-08-08
IT8448889A1 (en) 1986-03-21
FI843692A0 (en) 1984-09-20
FI843692L (en) 1985-03-23
IL73008A0 (en) 1984-12-31
LU85551A1 (en) 1985-04-29
NL8402755A (en) 1985-04-16
DK450784A (en) 1985-03-23
IT8448889A0 (en) 1984-09-21
ES8601146A1 (en) 1985-11-01

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Effective date: 19860815