FI74818B - Foerfarande foer detektering eller bestaemning av histamin i histaminhaltiga kroppsvaetskor och analytisk anordning foer dylikt foerfarande. - Google Patents

Foerfarande foer detektering eller bestaemning av histamin i histaminhaltiga kroppsvaetskor och analytisk anordning foer dylikt foerfarande. Download PDF

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Publication number
FI74818B
FI74818B FI830732A FI830732A FI74818B FI 74818 B FI74818 B FI 74818B FI 830732 A FI830732 A FI 830732A FI 830732 A FI830732 A FI 830732A FI 74818 B FI74818 B FI 74818B
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FI
Finland
Prior art keywords
histamine
labeled
foerfarande
microfibers
bound
Prior art date
Application number
FI830732A
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English (en)
Finnish (fi)
Other versions
FI830732L (fi
FI74818C (sv
FI830732A0 (fi
Inventor
Per Stahl Skov
Svend Norn
Bent Weeke
Original Assignee
Per Stahl Skov
Svend Norn
Weeke Bengt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Per Stahl Skov, Svend Norn, Weeke Bengt filed Critical Per Stahl Skov
Publication of FI830732L publication Critical patent/FI830732L/fi
Publication of FI830732A0 publication Critical patent/FI830732A0/fi
Publication of FI74818B publication Critical patent/FI74818B/fi
Application granted granted Critical
Publication of FI74818C publication Critical patent/FI74818C/sv

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/804—Radioisotope, e.g. radioimmunoassay
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/808—Automated or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/81—Tube, bottle, or dipstick
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/811—Test for named disease, body condition or organ function
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/145555—Hetero-N
    • Y10T436/147777—Plural nitrogen in the same ring [e.g., barbituates, creatinine, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physiology (AREA)
  • Endocrinology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Claims (13)

1. Förfarande för detektering eller bestämning av histamin i en kroppsvätska, varvid ett prov av kroppsvätskan 5 bringas i kontakt raed ett bindemedel för histamin och den bundna mängden registreras eller mätes, känneteck-n a t av att vätskeprovet och valbart en pä förhand bestämd mängd märkt histamin bringas i kontakt med krossade boro-silikat-glasmikrofibrer avsatta pä och fixerade vid ett un-10 derlag i sädana kvantitativa proportioner mellan glasmikro- fibrerna och vätskan att det närvarande histaminet tilläts bindas till mikrofibrerna, och att den tili mikrofibrerna bundna mängden histamin registreras eller mätes utan föregä-ende desorption antingen genom konkurrensbestämning baserad 15 pä en standardkurva för kända mängder av omärkt histamin eller genom direkt bestämning.
2. Förfarande enligt patentkrav 1 för bestämning av det histamin som möjligen frigjorts genom en allergisk reaktion, kännetecknat av att en testallergen till- 20 sätts en blodfraktion frän vilken plasman avlägsnats, och det eventuellt frigjorda histaminet, sora är bundet tili fibrerna, registreras eller mätes direkt eller i konkurrens raed märkt histamin.
3· Förfarande enligt patentkrav 1 eller 2, k ä n n e -25 tecknat av att de krossade glasraikrofibrerna sora an- vänds är i form av fina partiklar med dimensioner varierande mellan 2 och 20 μια.
4. Förfarande enligt nägot av patentkraven 1 - 3, kännetecknat av att borosilikat-glasmikrofibrer-30 na som används uppvisar följande oxidsammansättning: 23 7481 8 * ft Si02 57,9 CaO 2,6 B203 10,7 MgO 0,4 Fe203 5,9 BaO 5,0
5. Förfarande enligt nägot av patentkraven 1 - 4, 10 kännetecknat av att det märkta histamin som an- vänds är radioaktivt märkt, fluorescenamärkt eller enzym-märkt histamin eller hi staminderivat.
5 A1203 ZnO 3,9 N a20 10,1 F 0,6 K20 2,9
6. Analysanordning avsedd att användas vid detekte-ring eller bestämning av histamin i en kroppsvätska medelst 15 förfarandet enligt patentkrav 1 och 3, känneteck- n a d av att den omfattar ett analytiskt bindemedel för histamin, vilket är framställt genom krossning av borosili-kat-glasmikrofibrer för bildning av fina glasmikrofiberpar-tiklar, genom vai av en pä förhand bestämd mängd av de re- 20 sulterande glasmikrofibrerna med dimensionerna varierande melian 2 och 20 Mm och genom avsättning och fixering av de valda glasmikrofiberpartiklarna pl ett bärämne.
7. Analysanordning enligt patentkrav 6, k ä n n e -tecknad av att glasmikrofibrerna är borosi1ikatfibrer 25 med följande oxidsammansättning * % S iO 2 57,9 CaO 2,6 B203 10,7 MgO 0,4
30 Fe203 5,9 BaO 5,0 A120 3 ZnO 3,9 Na20 10,1 F 0,6 K20 2,9
8. Analysanordning enligt patentkrav 6, k ä n n e - tecknad av att glasmikro fibrerna är avsatta pä ett underlag, som är ett reagensrör, en mikrotiterplatta, en glasskiva, en folie eller en remsa.
FI830732A 1981-07-06 1983-03-04 Förfarande för detektering eller bestämning av histamin i histaminhalt iga kroppsvätskor och analytisk anordning för dylikt förfarande. FI74818C (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DK298281 1981-07-06
DK298281A DK157218C (da) 1981-07-06 1981-07-06 Fremgangsmaade til paavisning eller bestemmelse af histamin i legemsvaesker navnlig blod eller blodfraktioner, samt analyseanordning til anvendelse ved idoevelse af fremgangsmaaden
DK8200064 1982-07-06
PCT/DK1982/000064 WO1983000229A1 (en) 1981-07-06 1982-07-06 A method of detecting or determining histamine in histamine containing materials, particularly body fluids and an analytical means for use in such method

Publications (4)

Publication Number Publication Date
FI830732L FI830732L (fi) 1983-03-04
FI830732A0 FI830732A0 (fi) 1983-03-04
FI74818B true FI74818B (fi) 1987-11-30
FI74818C FI74818C (sv) 1988-03-10

Family

ID=8117827

Family Applications (1)

Application Number Title Priority Date Filing Date
FI830732A FI74818C (sv) 1981-07-06 1983-03-04 Förfarande för detektering eller bestämning av histamin i histaminhalt iga kroppsvätskor och analytisk anordning för dylikt förfarande.

Country Status (9)

Country Link
US (2) US4550085A (sv)
EP (1) EP0082862B1 (sv)
JP (1) JPS58501055A (sv)
AU (1) AU563306B2 (sv)
DE (1) DE3268798D1 (sv)
DK (1) DK157218C (sv)
FI (1) FI74818C (sv)
NO (1) NO830732L (sv)
WO (1) WO1983000229A1 (sv)

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CA1226796A (en) * 1983-11-07 1987-09-15 Anand Kumar Reflective particle-containing analytical element
CA1225574A (en) * 1983-11-07 1987-08-18 Anand Kumar Reflective particle-containing solvent extraction reagent composition
US5041390A (en) * 1988-08-11 1991-08-20 Skov Per S Method and means for allergy diagnosis
US5098831A (en) * 1988-08-11 1992-03-24 Allergifonden Af 1981 Method and means for allergy diagnosis
ATE113125T1 (de) * 1988-08-11 1994-11-15 Allergifonden Af 1981 Verfahren und mittel- zur diagnose für allergien.
US5468650A (en) * 1988-10-17 1995-11-21 A/S Lundbeck Export Division Ltd. Class microfiber histamine assay device
US5279937A (en) * 1992-04-30 1994-01-18 Detechnology Canada Use of macroglobulins to improve the signal-to-background ratio in affinity binding assays
WO2000018892A1 (fr) * 1998-09-25 2000-04-06 Kikkoman Corporation Histamine deshydrogenase, procede de production, procede de decelement quantitatif de l'histamine et reactif de decelement quantitatif
US8420054B2 (en) * 2009-09-18 2013-04-16 The Procter & Gamble Company Noninvasive method for measuring histamine from skin as an objective measurement of itch
WO2011056561A1 (en) 2009-10-27 2011-05-12 Beth Israel Deaconess Medical Center Methods and compositions for the generation and use of conformation-specific antibodies
US10487114B2 (en) 2011-04-27 2019-11-26 Beth Israel Deaconess Medical Center, Inc. Methods for administering peptides for the generation of effective c/s conformation-specific antibodies to a human subject in need thereof
US20140179748A1 (en) 2012-12-14 2014-06-26 The Procter & Gamble Company Antiperspirant and Deodorant Compositions
US9176110B1 (en) * 2013-09-13 2015-11-03 The United States Of America, As Represented By The Secretary Of Agriculture Method of determining histamine concentration in fish
RU2622003C1 (ru) * 2016-06-15 2017-06-08 Федеральное государственное бюджетное учреждение "Государственный научный центр "Институт иммунологии" Федерального медико-биологического агентства России Способ оценки гиперчувствительности по высвобождению гистамина из лейкоцитов цельной крови
US20220412961A1 (en) * 2019-11-15 2022-12-29 President And Fellows Of Harvard College Device and method for analyte detection
CN112326578B (zh) * 2020-12-01 2024-04-12 云南省农业科学院农产品加工研究所 一种快速检测食品中组胺的方法

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Also Published As

Publication number Publication date
DK298281A (da) 1983-01-07
DK157218B (da) 1989-11-20
FI830732L (fi) 1983-03-04
WO1983000229A1 (en) 1983-01-20
JPS58501055A (ja) 1983-06-30
JPH0319948B2 (sv) 1991-03-18
AU8685982A (en) 1983-02-02
DE3268798D1 (en) 1986-03-13
EP0082862B1 (en) 1986-01-29
US4869875A (en) 1989-09-26
AU563306B2 (en) 1987-07-02
US4550085A (en) 1985-10-29
EP0082862A1 (en) 1983-07-06
FI74818C (sv) 1988-03-10
FI830732A0 (fi) 1983-03-04
DK157218C (da) 1990-04-23
NO830732L (no) 1983-03-03

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Legal Events

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MM Patent lapsed
MM Patent lapsed

Owner name: SKOV, PER STAHL

Owner name: WEEKE, BENT

Owner name: NORN, SVEND