FI72254C - EN PRODUKT FOER UTBREDNING PAO HUDEN, FOER HYGIENI OCH / ELLER FOERHINDRANDE AV INFLAMMATIONER. - Google Patents

Description

72254

SKIN APPLICATION FOR HYGIENE AND / OR FIRE PREVENTION - EN PRODUKT FÖR UTBREDNING PA HUDEN, FÖR HYGIENI OCH / ELLER FÖRHINDRANDE AV INFLAMMATIONER

The invention relates to a product for application to the skin of persons or animals for hygiene and / or prevention of inflammation, in which an active ingredient formed by at least one antibacterial compound has been added to a cleaning or hygiene-promoting base. One of the compounds is 5-O-1-ior-2-methyl-4-iothiazolin-3-one - and another is 2-methyl-4-isothiazolin-3-one. oni derivative.

Healthcare and social work personnel regularly have to clean their skin in the course of their work, both for hygienic reasons and to avoid bacterial infection. The problem has been that a cleaning agent intended solely to remove dirt is quite ineffective against harmful bacteria. An effective bactericidal treatment agent, in turn, causes side effects in long-term use.

20 These include cracks and irritations in the skin as a result of the removal of protective fat from the skin. Efforts have been made to prevent problems by using a skin care agent suitable for after-care of the skin, which is cumbersome and uneconomical.

25 In the field of industrial livestock and animal husbandry, the cleaning of the skin under the fur or feather cover of the animals and the control of harmful bacteria are particularly difficult. Agents that are effective in killing bacteria have been shown to easily cause hair loss in animals as well as local skin damage. In addition, the use of such substances is limited by the self-cleaning of the animals, whereby the pesticide enters the animal's digestion.

U.S. Pat. No. 4,105,431 lists 3-isothiazolyl compounds in which the 2-radical is a carbon compound. The use of isothiazolines as biocides is known from ide31920. The isothiazoline metal compounds known as storage-stable biocides are disclosed in U.S. Patent No. 4,067-78 and U.S. Pat. No. 3,770,795 in Patent 5. These compounds are not suitable for the applications referred to in the application. GB 1,575,226 and U.S. Pat. No. 3,761,466 disclose the use of certain 3-isothiazoline compounds in dyes, heating oils and non-heating oils, as well as preservation for this purpose. Also known are some mixtures of these compounds with quaternary Len ammonium salts, which have been used for bactericidal purposes in industrial plants, poultry farming environments, dairies and grain warehouses, as disclosed in GB 1 466 15 691 and GB 1 466 692.

The invention led to the surprising finding that certain product compositions were effective in removing dirt and limiting the viability and growth of bacteria on the skin surface covered by the concept. At the same time, it was found that despite this effective hygienic effect, a therapeutic effect was obtained on this skin surface, which compensates for the side effects of dirt and anti-bacterial treatment. In addition, it was found that it was possible to produce a product which is easy and pleasant to use, easy to store, inexpensive and which is preferably not flammable and does not cause annoying gasification products.

The features of the invention are set out in claim 1. The object of the invention and its surprising properties are achieved by adding to the cleaning or hygiene-promoting base the active ingredient in an amount of at least 0.02 and preferably at most 3% by weight of the product. In this context, basic material means a substance suitable for removing and removing dirt or a hygiene-promoting substance which is used for purposes other than the treatment of Jia. The domain is a mixture of at least two compounds in which the first component is 5-chloro-2-methyl-4-isothiazol-3-one metal salt ylide (compound Al and the other is 2-methyl). 4-iso11azol-3-one-3-one is 1 (i, 1).

The compounds have the form: o Γ o

Il II

10 / \ / c \ H-Π N-CH (MX) 11-C N-CIL (MX) o, .LI, J_j ·

And L And (A) (B) 15 where M = the cation formed by the metal or its complex, X = the anion, a = 1 or 2 n = the integer determining the valence equilibrium of the cation and the amine, and where the metal of the cation is alkali-20 or earth. alkali metal 11i, preferably Li. Na, K, Rb, Mg, Ca or Ba, or a metal of the Periodic Table IIb or a metal of order 24-29, preferably Zn, Cr, Fe, Co, Ni or Cu, or silver, tin, lead or arnmon i um l is i . In a preferred embodiment of the invention, the cations of the compounds are preferably Na, K, Li or ammonium ion, or most preferably Mg or

Ca.

The relative weight amounts of the active ingredient components in the ratio A- + -B are preferably at least 1: 1, more preferably at most 5: 1. The product contains a total of 0.02 to 0.0% by weight of these components, based on the weight of the product. The technical potency of the active ingredient can be increased by adding a number of hedgehogs, 0.02% by weight, of the product, an antibacterial compound, for example 2, 4, 4 * -1-chloro-2 * -hydroxydiphenyl compound. or imida t so 1 id inyyyy 1 iur ea-compound

A

72254 or 1,1 * -hexamethylene-bis-η 5 - (p-chlorophenyl) -biguanide-1-digluconyl compound (hereinafter KHHG).

The after-treatment of the skin, i.e. the compensation of the side effects of dirt and antibacterial treatment, is carried out with one or more substances added to the base material which are suitable for skin care, its softening and / or the removal of the swelling effects of the antibacterial treatment. An antioxidant, a preservative and, for convenience, an odor-producing substance are also preferably added to the base material.

JL O The base material may be in the form of a soap, a synthetic or semi-synthetic cleanser, a cream, a gel-like or a liquid skin care agent, such as a so-called lotion, or an aqueous solution of a low molecular weight alcohol. The soap may be a long-term alkaline or ammonium salt of a fatty acid 15 known per se, comprising carbon atoms Θ ... 25 in the molecule. Proteins or lipoproteins may be added to the soap or cleanser. The alcohol solution is required to be at most mildly toxicological. This preferred application is suitable e.g. to sterilize hands prior to medical procedures such as surgical surgery. Preferably, this solution is an aqueous solution which produces no more than a small amount of harmful fumes, preferably a non-flammable.

The invention is described with reference to exemplary embodiments in which the effect of the product has been studied with standardized test organisms Staphylococcus aureus (ATCC 653Θ) and Salmonella tvphi (ATCC 6539). Tissue standard A.O.A.C. (American Association of Official Analytical Chemists) is presented in Methods of Analysis, 12th Edition, pages 57 and 61, “Available Chlorine Germicidal Equivalent Concentration 30 Respectively”.

The products studied have the following composition (Examples 1-4):

II

3 72254

Execution Example 1

Weight percent (1) Sodium lauryl sulphate 30.00 (2) Cocoamidopropyl beta 7.5 t- (3) Ethylene glycol stearate 9.5 (4) Collagen 2.5 (5) Landinacidalchi 1 ammonium sulphate 0.5 (6) Sodium chloride 0.5 (7) ) Deionized HM0 4 9.33 (Θ) Compound mixture (A, B) 0.04

Embodiment 2 15 (I) - (6) in the mutual ratio of Example 1 5q, - (Θ) Compound mixture (A, B) ^ (9) 2,4,4 * -1 r to oor i-2 * -hydroxy 1 i eet ter in

^ · X

(10) Propylene glycol o 20 (7) De ionized H 2 O 0 rest

Embodiment 3 25 (1) to (7) in the ratio of Example 1 99 Ac (Θ) Mixture of compounds (Α, Β), ot> 0.03 (II) N, Ν * -methylenebis s- [n * - [1- (hydroxymethyl) ^ 2,5-dioxo-4-imidazolidinyl] urea 0.3 30

Embodiment 4 6 72254 (1) to (7) in the ratio of Example 1 99.65 (Θ) Compound mixture (A, B) 0.03 (12) KHHG 0.3 0.3 The antibacterial compounds shown in Examples 2-4 were varied between these exemplary products. 0.02 to 2% by weight of the product by varying the proportion of water, components (1) to (7) or a combination thereof, respectively. As the proportion of component (9), (J1) or (12) was increased, the rate and spectral range of the antibacterial effect of the product were increased compared to the properties of Example 1. The objects of the invention were achieved in all variations. Observations were made in experiments in which the concentration of the compound mixture Λ, ensin was first a preselected parameter and the concentration of the compound (9), (11) or (12) was used as a variable.

In the second step, the concentration of the compound mixture was a variable and each of the compounds (9), (11) or (12) was a parameter. The component ratios shown in Examples 2 to 4 were found to correspond to a sufficiently fast-acting and at the same time economic composition.

The proportion of the mixture of compounds (A, B) described in Examples 1-4 was varied between 0.002 and 3% by weight of the product. In this case, the proportion of water, components (1) to (6) or a combination thereof or the proportion of compound (10) was changed accordingly (Example 2). The addition of the compound mixture increased the effect of the product, accelerated the activity against bacteria and at the same time realized the objects of the invention. The 30 proportions described in Examples 1-4 produced a sufficiently effective and rapid effect, while being an economical choice.

The components A and B of the mixture compound (A, B>) were varied so that their weight ratios varied between 1: 1 ... 5: 1, 35 whereby a technical effect was observed in all ratios.

t

If 7 72254

The best technical performance was found in the ratio. Which is between 2.8 ... 3.3: 1. The technically easiest ratio proved to be about 3: 1. The M-cations in components Λ and B were studied and it was found that the best result was obtained using magnesium and almost as good with calcium-3. Good results were observed when the cation was sodium, potassium, lithium or ammonium ion. Short-term or temporary use did not cause side effects with iron or silver.

The preferred modification of Example 1 comprises about 3: 1 with a magnesium cation, components A and B, and a proportion of between 0.02 and 0.8% by weight of the product. The simplest control of this transformation is performed by changing the proportion of water accordingly.

13 A study of performance examples in a culture of Salmonella tvphi (ATCC 6539) in a thioglycollate medium showed the following:

Direct Example Subculture Series 20 123456789 10 1 + --------- 2 - - - ------ - 3 ---------- 25 4 --------- -

Culture growth (+) and no growth (-) are indicated in the table.

30

Sodium hypochlorite at different concentrations was used as a reference: 72254

NaOCl concentration Horticultural series ppm (free Cl) 1234567Θ910 200 ----- +++++ 5 100 --- +++++++ 50 - +++++++

The resistance of the bacterial strain to phenol solutions of different concentrations compared to the contact time was studied:

Phenol dilution Contact time (minutes) 5 10 15 15 1:00 + - _ 1:90 + + 1: 100 + + + 20 Experiments show that the products of Examples 1-4 are more effective against Salmonella tvphi-vi 1. the concentration is 200 ppm. The culture is then resistant to a 1:60 phenol solution.

25 The study of Staphylococcus aureus showed that:

Performance brand Gardening series 12345670 9 10 3 0 j ---- + ----- 2 ---------- 3 ---------- 4 ------- --- 9

Sodium hypochlorite i 11i value 1 u: * ^ 2254

NaOCl concentration Subprogram series ppm (free Cl) 1 2 3 (; 6 7 6 9 10 e = 200 - - - + + + ^ 100 --- +++++++ 50 - “++++++ ++

Resistance of the culture to the phenol solution: ΙΟ Dilution of phenol i Contact time (minutes) 5 10 15 1:60 + + + 15 1:70 4 - - 1:60 - - -

An example of Staphylococcus aurem-koc shows that the products are more effective against a bacterial culture than chlorine with a free content of 200 ppm, the culture being resistant to a 1:70 phenol solution.

Embodiments 1-4 above and the variations described therein have proven to be products which are very well tolerated by human skin and which are well suited for hygienic purposes. The products proved to have a broad spectrum of antibacterial activity with which the amount of bacteria on the skin can be significantly reduced. The products can prevent bacterial infection of the skin, as well as bacterial contamination. Sterilization of the hands 30 has proven possible with a mixture of compounds (A, B) added to an aqueous solution of ethanol or isopropanol when this compound is present in an amount of 0.02 to 0.60% by weight of the product.

«ΙΟ 72254

The technical efficacy of the invention was also studied in a product in which the base substance is a skin care agent. The products are described in the following working examples.

Example 5 5% by weight (13) Ethyl alcohol 2.5 (14) Stearic acid 15.0 (15) Isostearyl laurate 7.0 q (16) Si 1 icon 0.5 (17) Butylhydroxytoluene 0.025 (18) Sodium cetearyl sulphate 2.5 (19) Ethylenediaminetetraacetic acid disodium salt 0.05 (8) Compound mixture (A, B) 0.2 ... 0.6 (7) Deionized H- ^ O rest 1 5

Embodiment 6 (13) to (19), (8) as in Example 5

2 O

(9) 2,4,4 * -1-chloro-2 * -hydroxydiphenyl ether 0,1 (7) Deionized Η-.Ό rest

Embodiment 7 25 (13) to (19), (8) as in Example 5 (11) N, N * -methylenebis-N, N-1 - (hydroxy) 5-Dioxo-4-imidazol idinyl and urea 0.3 (7) Deionized Hs-O Remaining 30

Embodiment 8 (13) to (19), (8) as in Example 5 (12) KHHG 0.3 35 1 1 72254 (7) Deionized H = 0 rest

The compounds (9), (11) and (12) shown in Examples 6-Θ were varied between 0.02 and 2% by weight of the product.

Components (7) to (0), (13) to (19) were modified as shown in Examples 2-4, as applicable. The effect of the product compared to the properties of Example 5 followed the same pattern as products 2-4 compared to product 1 when the observations were made in similar parameter variables ko-j q ke i s sa.

The properties of the Examples 5-Θ were studied by varying the proportion of the compound mixture (A, B) between 0.2 and 0.6% by weight. The proportion of other components was changed as described in Examples 1-4. The proportion of components (13) to (19) was also set to the amount reported in Example 5, with the proportion of deionized water being determined from the total amount of other components of the product. The products shown in Examples B-β, as well as the variations of the products described, produced the effects and technical efficacy described in connection with pre-20 marks 1-4. The components of the mixed compound (Λ.Β) were varied between 1: 1 ... 5: 1 and the M cation was varied in the products. The same favorable and good results were found as described in connection with Examples 1-4.

A preferred variant of Example 5 comprises the magnesium cation, components A, B in a ratio of about 3: 1 and in a proportion of 0.02 to 0.6% by weight. Preferred variants of Examples 6-Θ contain this variant and components (9) 0.1 or (11) 0.3 or (12) 0.3% by weight.

The invention is not limited to the embodiments shown, but several variations thereof are conceivable within the scope of the appended claims. For example, instead of soap or cream, a gel-like skin care agent may be used in which

Claims (10)

A product for application to the skin of persons or animals for hygiene and / or prevention of inflammation, in which an active ingredient consisting of at least one antibacterial compound, one of which (A) is 5-chloro-2-, is added to a cleansing or hygiene-promoting base. methyl-4-isothiazolin-3-one derivative and another (B) is a 2-methyl-4-isothiazolin-3-one derivative, characterized in that the active ingredient is formed by at least two compounds (A, B) a mixture of which the first (A) is a 5-chloro-2-methyl-4-isothiazolin-3-one methyl compound and the second (B) is a 2-methyl-4-isothiazolin-3-one metal salt that the active ingredient is at least 0.02 and preferably at most 3% by weight of the product, and that the compounds (A, B) have the form: Γ ° Ί Γ 0 1 25 1 0 / \ / \ HT. “Α, 3 (HV H '| C | γα, 3 <MXn) C1-CS HCi · * L And (A) (B) 1 3 72 2 5 4 where M = cation formed by the metal or its complex X = anion, a = 1 or 2 n = the integer determining the valence equilibrium of the cation and the anion, and where the dirt ion n metal is alkaline or earth a 1 kaa 1 ime ta 11 i, preferably Li, Na, K, Rb, ^ Mg, Ca or Ba , or a metal of the Periodic Table IIb or an order of 24 to 29, preferably Zn, Cr, Mn, Fe, Co, Ni or Cu, or is silver, tin, lead or ammonium ion. 1 2 72254 components (7) to (0) and (9) or (11) or (12) are modified as described in Examples 5-Θ, as applicable. The most preferred cation is magnesium, preferred calcium or sodium, and ammonium ion suitable for short-term use. Product according to Claim 1, characterized in that the cations of the first compound (Λ) and the second compound (B) are preferably Na, K, Li or ammonium ion, or most preferably Mg or Ca. Product according to Claim 1 or 2, characterized in that the relative weight amounts of the first (A) and second (B) compounds in the active ingredient are 1: 1, preferably at most 5: 1, these (A, B) being present in the product. 0.02 ... 0.8% by weight. Product according to one of Claims 1 to 3, characterized in that the mixture contains the antibacterial compound 2,4,4 * -trichloro-2 * -hydroxydiphenyl ether in an amount corresponding to 0.02 to 2% by weight of the product. Product according to one of Claims 1 to 3, characterized in that the mixture contains the antibacterial imidazolidinyl urea compound in an amount corresponding to 0.02 to 2% by weight of the product. 5 PATENT CLAIMS Product according to one of Claims 1 to 3, characterized in that the mixture contains an amount of the antibacterial 1,1 * -hexamethylene-bis-5- (p-chlorophenyl) -biguanide] digluconate compound, corresponding to 0.02 ... 2% by weight of the product. Product according to one of the preceding claims, characterized in that the base contains at least one substance for treating, softening or eliminating the swelling effects of anti-bacterial treatment, and preferably also a substance for perfuming, preserving and / or preventing oxidation. . Product according to any one of the preceding claims, characterized in that said base material is a soap, such as a long-chain alkaline or amniumium fatty acid salt known per se comprising Θ ... 25 atoms in the molecule, a synthetic or semi-synthetic detergent, and preferably the proteins contain proteins and / or lipoproteins. Product according to one of Claims 1 to 6, characterized in that the base substance is a creamy, gel-like or liquid skin care agent. Product according to one of Claims 1 to 6, characterized in that the basic substance is at most a slightly toxic aqueous solution of a low-molecular-weight alcohol.