FI58490C - Foerfarande foer framstaellning av nya terapeutiskt anvaendbara substituerade 2-amino-prop-1-ener och deras cis- och trans-isomerer och deras syraadditionssalter - Google Patents
Foerfarande foer framstaellning av nya terapeutiskt anvaendbara substituerade 2-amino-prop-1-ener och deras cis- och trans-isomerer och deras syraadditionssalter Download PDFInfo
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- FI58490C FI58490C FI3668/72A FI366872A FI58490C FI 58490 C FI58490 C FI 58490C FI 3668/72 A FI3668/72 A FI 3668/72A FI 366872 A FI366872 A FI 366872A FI 58490 C FI58490 C FI 58490C
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- 229910000037 hydrogen sulfide Inorganic materials 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- INQOMBQAUSQDDS-UHFFFAOYSA-N iodomethane Chemical compound IC INQOMBQAUSQDDS-UHFFFAOYSA-N 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- OTCKOJUMXQWKQG-UHFFFAOYSA-L magnesium bromide Chemical compound [Mg+2].[Br-].[Br-] OTCKOJUMXQWKQG-UHFFFAOYSA-L 0.000 description 1
- 229910001623 magnesium bromide Inorganic materials 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229910052987 metal hydride Inorganic materials 0.000 description 1
- 150000004681 metal hydrides Chemical class 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 description 1
- 230000000269 nucleophilic effect Effects 0.000 description 1
- NIHNNTQXNPWCJQ-UHFFFAOYSA-N o-biphenylenemethane Natural products C1=CC=C2CC3=CC=CC=C3C2=C1 NIHNNTQXNPWCJQ-UHFFFAOYSA-N 0.000 description 1
- 239000012044 organic layer Substances 0.000 description 1
- 238000006053 organic reaction Methods 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- FVSKHRXBFJPNKK-UHFFFAOYSA-N propionitrile Chemical compound CCC#N FVSKHRXBFJPNKK-UHFFFAOYSA-N 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000012279 sodium borohydride Substances 0.000 description 1
- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000012265 solid product Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 238000001256 steam distillation Methods 0.000 description 1
- JDVPQXZIJDEHAN-UHFFFAOYSA-N succinamic acid Chemical compound NC(=O)CCC(O)=O JDVPQXZIJDEHAN-UHFFFAOYSA-N 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 125000004434 sulfur atom Chemical group 0.000 description 1
- 150000003464 sulfur compounds Chemical class 0.000 description 1
- 230000017105 transposition Effects 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/782—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic
- C07C49/788—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic with keto groups bound to a condensed ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
- C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5407—Acyclic saturated phosphonium compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/18—Fluorenes; Hydrogenated fluorenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1516973A GB1434714A (en) | 1971-12-29 | 1971-12-29 | 3-amino-prop-1-enes methods for their preparation |
| GB6031571 | 1971-12-29 | ||
| GB4874872 | 1972-10-23 | ||
| GB4874872 | 1972-10-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FI58490B FI58490B (fi) | 1980-10-31 |
| FI58490C true FI58490C (fi) | 1981-02-10 |
Family
ID=26266323
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI3668/72A FI58490C (fi) | 1971-12-29 | 1972-12-28 | Foerfarande foer framstaellning av nya terapeutiskt anvaendbara substituerade 2-amino-prop-1-ener och deras cis- och trans-isomerer och deras syraadditionssalter |
| FI794000A FI794000A7 (fi) | 1971-12-29 | 1979-12-20 | Uusia, substituoituja 3-amino-prop-l- eenien valmistuksessa käytettäviä välituotteita. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI794000A FI794000A7 (fi) | 1971-12-29 | 1979-12-20 | Uusia, substituoituja 3-amino-prop-l- eenien valmistuksessa käytettäviä välituotteita. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US3932663A (https=) |
| JP (1) | JPS5750774B2 (https=) |
| AR (3) | AR205875A1 (https=) |
| BE (1) | BE793469A (https=) |
| CA (1) | CA1009255A (https=) |
| CH (5) | CH598191A5 (https=) |
| DE (1) | DE2263817A1 (https=) |
| DK (1) | DK143897C (https=) |
| ES (2) | ES410122A1 (https=) |
| FI (2) | FI58490C (https=) |
| FR (1) | FR2166122B1 (https=) |
| HU (1) | HU166958B (https=) |
| IL (1) | IL41200A (https=) |
| NL (1) | NL7217642A (https=) |
| SE (2) | SE395142B (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4079081A (en) * | 1971-12-29 | 1978-03-14 | Burroughs Wellcome Co. | 1,1-Diaryl-3-amino-prop-1-enes |
| FR2223028B1 (https=) * | 1973-03-28 | 1977-05-06 | Wellcome Found | |
| PH14982A (en) * | 1979-06-14 | 1982-03-05 | Beecham Group Ltd | 3-nitro-1-phenyl-1-(n-chlorophenyl)-propan-2-ol |
| EP0322151A3 (en) * | 1987-12-23 | 1989-10-04 | Imperial Chemical Industries Plc | Aromatic compounds |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1206427B (de) * | 1962-11-23 | 1965-12-09 | Giulini Gmbh Geb | Verfahren zur Herstellung von blutdruck-steigernden 2-Alkyl-3, 3-diphenylpropen-(2)-ylaminen |
-
0
- BE BE793469D patent/BE793469A/xx not_active IP Right Cessation
-
1972
- 1972-01-01 AR AR245898A patent/AR205875A1/es active
- 1972-12-13 US US05/314,845 patent/US3932663A/en not_active Expired - Lifetime
- 1972-12-27 NL NL7217642A patent/NL7217642A/xx not_active Application Discontinuation
- 1972-12-28 SE SE7217048A patent/SE395142B/xx unknown
- 1972-12-28 FR FR7246606A patent/FR2166122B1/fr not_active Expired
- 1972-12-28 IL IL41200A patent/IL41200A/en unknown
- 1972-12-28 DK DK650972A patent/DK143897C/da not_active IP Right Cessation
- 1972-12-28 CH CH1896272A patent/CH598191A5/xx not_active IP Right Cessation
- 1972-12-28 JP JP48004159A patent/JPS5750774B2/ja not_active Expired
- 1972-12-28 FI FI3668/72A patent/FI58490C/fi active
- 1972-12-28 DE DE2263817A patent/DE2263817A1/de not_active Ceased
- 1972-12-28 ES ES410122A patent/ES410122A1/es not_active Expired
- 1972-12-29 HU HUWE475A patent/HU166958B/hu unknown
- 1972-12-29 CA CA160,202A patent/CA1009255A/en not_active Expired
-
1973
- 1973-01-01 AR AR250872A patent/AR206205A1/es active
- 1973-09-28 ES ES419165A patent/ES419165A1/es not_active Expired
-
1974
- 1974-01-01 AR AR256434A patent/AR205550A1/es active
-
1976
- 1976-02-16 SE SE7601707A patent/SE410311B/xx unknown
-
1977
- 1977-08-29 CH CH1050877A patent/CH609326A5/xx not_active IP Right Cessation
- 1977-08-29 CH CH1050677A patent/CH609325A5/xx not_active IP Right Cessation
- 1977-08-29 CH CH1050577A patent/CH599105A5/xx not_active IP Right Cessation
- 1977-08-29 CH CH1050977A patent/CH598192A5/xx not_active IP Right Cessation
-
1979
- 1979-12-20 FI FI794000A patent/FI794000A7/fi not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| FR2166122B1 (https=) | 1977-04-15 |
| CH598191A5 (https=) | 1978-04-28 |
| CH599105A5 (https=) | 1978-05-12 |
| CH609326A5 (https=) | 1979-02-28 |
| DK143897B (da) | 1981-10-26 |
| IL41200A0 (en) | 1973-02-28 |
| HU166958B (https=) | 1975-06-28 |
| BE793469A (fr) | 1973-06-28 |
| CA1009255A (en) | 1977-04-26 |
| SE395142B (sv) | 1977-08-01 |
| SE410311B (sv) | 1979-10-08 |
| DE2263817A1 (de) | 1973-07-05 |
| CH598192A5 (https=) | 1978-04-28 |
| FI58490B (fi) | 1980-10-31 |
| FI794000A7 (fi) | 1981-01-01 |
| FR2166122A1 (https=) | 1973-08-10 |
| NL7217642A (https=) | 1973-07-03 |
| US3932663A (en) | 1976-01-13 |
| DK143897C (da) | 1982-04-13 |
| AR205550A1 (es) | 1976-05-14 |
| ES410122A1 (es) | 1976-01-01 |
| JPS5750774B2 (https=) | 1982-10-28 |
| ES419165A1 (es) | 1977-02-01 |
| AR206205A1 (es) | 1976-07-07 |
| CH609325A5 (https=) | 1979-02-28 |
| JPS4875552A (https=) | 1973-10-11 |
| IL41200A (en) | 1976-06-30 |
| SE7601707L (sv) | 1976-02-16 |
| AR205875A1 (es) | 1976-06-15 |
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