FI47885C - Process for the preparation of 1,2 alpha-methylene-6,7 alpha-difluoromethyl en-20-spirox-4-en-3-one - Google Patents

Process for the preparation of 1,2 alpha-methylene-6,7 alpha-difluoromethyl en-20-spirox-4-en-3-one

Info

Publication number
FI47885C
FI47885C FI722993A FI299372A FI47885C FI 47885 C FI47885 C FI 47885C FI 722993 A FI722993 A FI 722993A FI 299372 A FI299372 A FI 299372A FI 47885 C FI47885 C FI 47885C
Authority
FI
Finland
Prior art keywords
alpha
spirox
difluoromethyl
methylene
preparation
Prior art date
Application number
FI722993A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI47885B (en
Inventor
Arth
Rasmussen
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of FI47885B publication Critical patent/FI47885B/fi
Application granted granted Critical
Publication of FI47885C publication Critical patent/FI47885C/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI722993A 1969-05-14 1972-10-27 Process for the preparation of 1,2 alpha-methylene-6,7 alpha-difluoromethyl en-20-spirox-4-en-3-one FI47885C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82467269A 1969-05-14 1969-05-14
US2118370A 1970-03-19 1970-03-19

Publications (2)

Publication Number Publication Date
FI47885B FI47885B (en) 1974-01-02
FI47885C true FI47885C (en) 1974-04-10

Family

ID=26694377

Family Applications (2)

Application Number Title Priority Date Filing Date
FI701339A FI47355C (en) 1969-05-14 1970-05-13 Process for the preparation of 1,2-alpha-methylene-6,7alpha-difluoromethylene-20-spirox-4-en-3-one derivatives.
FI722993A FI47885C (en) 1969-05-14 1972-10-27 Process for the preparation of 1,2 alpha-methylene-6,7 alpha-difluoromethyl en-20-spirox-4-en-3-one

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FI701339A FI47355C (en) 1969-05-14 1970-05-13 Process for the preparation of 1,2-alpha-methylene-6,7alpha-difluoromethylene-20-spirox-4-en-3-one derivatives.

Country Status (17)

Country Link
JP (1) JPS532865B1 (en)
AR (1) AR192305A1 (en)
BE (1) BE750330A (en)
CA (1) CA926385A (en)
CH (2) CH547792A (en)
CS (2) CS151551B2 (en)
DE (1) DE2023450C3 (en)
DK (3) DK126992B (en)
FI (2) FI47355C (en)
FR (1) FR2051526B1 (en)
GB (1) GB1265444A (en)
IE (1) IE34194B1 (en)
IL (1) IL34431A (en)
NL (1) NL168844C (en)
NO (1) NO131131C (en)
SE (2) SE386904B (en)
YU (1) YU34052B (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3356677A (en) * 1966-04-05 1967-12-05 Syntex Corp 1alpha, 2alpha-and 6alpha, 7alpha-dihalomethylene androstenes

Also Published As

Publication number Publication date
IL34431A0 (en) 1970-07-19
FI47885B (en) 1974-01-02
CH547785A (en) 1974-04-11
NL168844C (en) 1982-05-17
DK127505B (en) 1973-11-19
SE386904B (en) 1976-08-23
IE34194B1 (en) 1975-03-05
FR2051526B1 (en) 1974-04-12
IL34431A (en) 1974-03-14
CH547792A (en) 1974-04-11
GB1265444A (en) 1972-03-01
FI47355B (en) 1973-07-31
DE2023450A1 (en) 1971-01-14
CS151552B2 (en) 1973-10-19
BE750330A (en) 1970-11-13
DE2023450C3 (en) 1979-05-31
AR192305A1 (en) 1973-02-14
CS151551B2 (en) 1973-10-19
DK127880C (en) 1974-06-10
NO131131B (en) 1974-12-30
SE366305B (en) 1974-04-22
IE34194L (en) 1970-11-14
NL7006474A (en) 1970-11-17
NL168844B (en) 1981-12-16
YU117670A (en) 1978-05-15
FI47355C (en) 1973-11-12
DE2023450B2 (en) 1978-10-05
YU34052B (en) 1978-10-31
DK127880B (en) 1974-01-28
NO131131C (en) 1975-04-09
FR2051526A1 (en) 1971-04-09
JPS532865B1 (en) 1978-02-01
CA926385A (en) 1973-05-15
DK126992B (en) 1973-09-10

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FI47885C (en) Process for the preparation of 1,2 alpha-methylene-6,7 alpha-difluoromethyl en-20-spirox-4-en-3-one