FI47885C - Process for the preparation of 1,2 alpha-methylene-6,7 alpha-difluoromethyl en-20-spirox-4-en-3-one - Google Patents

Process for the preparation of 1,2 alpha-methylene-6,7 alpha-difluoromethyl en-20-spirox-4-en-3-one

Info

Publication number
FI47885C
FI47885C FI722993A FI299372A FI47885C FI 47885 C FI47885 C FI 47885C FI 722993 A FI722993 A FI 722993A FI 299372 A FI299372 A FI 299372A FI 47885 C FI47885 C FI 47885C
Authority
FI
Finland
Prior art keywords
alpha
spirox
difluoromethyl
methylene
preparation
Prior art date
Application number
FI722993A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI47885B (en
Inventor
Arth
Rasmussen
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of FI47885B publication Critical patent/FI47885B/fi
Publication of FI47885C publication Critical patent/FI47885C/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI722993A 1969-05-14 1972-10-27 Process for the preparation of 1,2 alpha-methylene-6,7 alpha-difluoromethyl en-20-spirox-4-en-3-one FI47885C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82467269A 1969-05-14 1969-05-14
US2118370A 1970-03-19 1970-03-19

Publications (2)

Publication Number Publication Date
FI47885B FI47885B (en) 1974-01-02
FI47885C true FI47885C (en) 1974-04-10

Family

ID=26694377

Family Applications (2)

Application Number Title Priority Date Filing Date
FI701339A FI47355C (en) 1969-05-14 1970-05-13 Process for the preparation of 1,2-alpha-methylene-6,7alpha-difluoromethylene-20-spirox-4-en-3-one derivatives.
FI722993A FI47885C (en) 1969-05-14 1972-10-27 Process for the preparation of 1,2 alpha-methylene-6,7 alpha-difluoromethyl en-20-spirox-4-en-3-one

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FI701339A FI47355C (en) 1969-05-14 1970-05-13 Process for the preparation of 1,2-alpha-methylene-6,7alpha-difluoromethylene-20-spirox-4-en-3-one derivatives.

Country Status (17)

Country Link
JP (1) JPS532865B1 (en)
AR (1) AR192305A1 (en)
BE (1) BE750330A (en)
CA (1) CA926385A (en)
CH (2) CH547792A (en)
CS (2) CS151551B2 (en)
DE (1) DE2023450C3 (en)
DK (3) DK126992B (en)
FI (2) FI47355C (en)
FR (1) FR2051526B1 (en)
GB (1) GB1265444A (en)
IE (1) IE34194B1 (en)
IL (1) IL34431A (en)
NL (1) NL168844C (en)
NO (1) NO131131C (en)
SE (2) SE386904B (en)
YU (1) YU34052B (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3356677A (en) * 1966-04-05 1967-12-05 Syntex Corp 1alpha, 2alpha-and 6alpha, 7alpha-dihalomethylene androstenes

Also Published As

Publication number Publication date
IL34431A0 (en) 1970-07-19
FI47885B (en) 1974-01-02
IE34194L (en) 1970-11-14
DK126992B (en) 1973-09-10
DE2023450A1 (en) 1971-01-14
FI47355B (en) 1973-07-31
NL168844C (en) 1982-05-17
FI47355C (en) 1973-11-12
IE34194B1 (en) 1975-03-05
DK127505B (en) 1973-11-19
CH547785A (en) 1974-04-11
SE386904B (en) 1976-08-23
DE2023450C3 (en) 1979-05-31
BE750330A (en) 1970-11-13
CS151551B2 (en) 1973-10-19
JPS532865B1 (en) 1978-02-01
DK127880C (en) 1974-06-10
CH547792A (en) 1974-04-11
NL168844B (en) 1981-12-16
FR2051526A1 (en) 1971-04-09
DK127880B (en) 1974-01-28
NL7006474A (en) 1970-11-17
NO131131B (en) 1974-12-30
YU117670A (en) 1978-05-15
GB1265444A (en) 1972-03-01
SE366305B (en) 1974-04-22
DE2023450B2 (en) 1978-10-05
NO131131C (en) 1975-04-09
YU34052B (en) 1978-10-31
AR192305A1 (en) 1973-02-14
CA926385A (en) 1973-05-15
IL34431A (en) 1974-03-14
FR2051526B1 (en) 1974-04-12
CS151552B2 (en) 1973-10-19

Similar Documents

Publication Publication Date Title
FI48062C (en) Process for the preparation of xylitol
SE409708B (en) PROCEDURE FOR THE PREPARATION OF 2,4-DIAMINO-5-BENZYLPYRIMIDINES
FI49716C (en) Process for the preparation of 2,4-diamino-5-benzyl-pyrimidines.
NO741223L (en) Process for the preparation of 6-deoxytetracyclines.
BE756725A (en) PROCESS FOR THE PREPARATION OF 3,3,3-TRIFLUOROPROPYLMETHYLPOLYSILOXANES
FI50334C (en) Process for the preparation of 1-hydroxy-2-pyridones.
BG17560A3 (en) METHOD FOR THE PREPARATION OF 4,20, 22- BUFATRIENOL- DRAMNOSIDE-ETHERS
FI47575C (en) Analogous process for the preparation of evomonoside derivatives.
FI51700C (en) Process for the preparation of 6-phenyl-4H-s-triazolo (1,5a) (1,4) -benzodiazepines useful as sedatives.
FI52216C (en) Process for the preparation of gamma-piperidinobutyrophenone derivatives.
FI49161C (en) Process for the preparation of cardenolide-3- (2´, 3´-didesoxy-2´, 3´-oxy do-glycosides).
FI50407C (en) Process for the preparation of trichloromonosilanes
FI46844C (en) Process for the preparation of 9alpha, 21,21-trichlorosteroids.
FI47577C (en) Process for the preparation of 2,4,7-triamino-6-phenyl-pteridines.
FI51183C (en) Process for the preparation of 2-hydroxymethyl-3-carboxylic acid amido-quinoxaline-di-N-oxide (1,4) compounds.
FI47183C (en) Process for the preparation of pure digoxin-3 "" - monomethyl ether.
FI51496C (en) Process for the preparation of vanadium carbide.
FI47763C (en) Process for the preparation of new neriifoline derivatives.
FI49029C (en) Process for the preparation of 15alpha, 16alpha-methyleneandrostene derivatives
FI52088C (en) Process for the preparation of 3- (4-acyloxyalkyl-1-piperazinyl) -carbonylmethyl-2-benzothiazolinone derivatives.
SE398878B (en) PROCEDURE FOR THE PREPARATION OF SUBSTITUTED 2,4-DIAMINO-5-BENZYLPYRIMIDINES
FI47349C (en) Process for the preparation of 17alpha-propadienyl-17beta-hydroxy-steroids.
FI46724C (en) Process for the preparation of 1,18-dimethyl-5-alpha-H-androst-1-enderivat.
FI51814C (en) Process for the preparation of alpha-carboxybenzylpenicillin.
FI47885C (en) Process for the preparation of 1,2 alpha-methylene-6,7 alpha-difluoromethyl en-20-spirox-4-en-3-one