DK126992B - Analogous process for the preparation of 1,2α-methylene-6,7α-dihalomethylene-20-spirox-4-en-3-one compounds. - Google Patents

Analogous process for the preparation of 1,2α-methylene-6,7α-dihalomethylene-20-spirox-4-en-3-one compounds.

Info

Publication number
DK126992B
DK126992B DK243670AA DK243670A DK126992B DK 126992 B DK126992 B DK 126992B DK 243670A A DK243670A A DK 243670AA DK 243670 A DK243670 A DK 243670A DK 126992 B DK126992 B DK 126992B
Authority
DK
Denmark
Prior art keywords
spirox
dihalomethylene
methylene
compounds
preparation
Prior art date
Application number
DK243670AA
Other languages
Danish (da)
Inventor
G Arth
G Rasmusson
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of DK126992B publication Critical patent/DK126992B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK243670AA 1969-05-14 1970-05-13 Analogous process for the preparation of 1,2α-methylene-6,7α-dihalomethylene-20-spirox-4-en-3-one compounds. DK126992B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82467269A 1969-05-14 1969-05-14
US2118370A 1970-03-19 1970-03-19

Publications (1)

Publication Number Publication Date
DK126992B true DK126992B (en) 1973-09-10

Family

ID=26694377

Family Applications (3)

Application Number Title Priority Date Filing Date
DK243670AA DK126992B (en) 1969-05-14 1970-05-13 Analogous process for the preparation of 1,2α-methylene-6,7α-dihalomethylene-20-spirox-4-en-3-one compounds.
DK377671AA DK127505B (en) 1969-05-14 1971-08-02 Analogous process for the preparation of 3,21-dioxygenated 1,2α-methylene-6,7α-dihalomethylene-20-spirox-4-ene compounds.
DK590571AA DK127880C (en) 1969-05-14 1971-12-02 Analogous process for the preparation of 3-oxo-1,2α-methylene-dihalomethylene-20-spirox-4-ene compounds.

Family Applications After (2)

Application Number Title Priority Date Filing Date
DK377671AA DK127505B (en) 1969-05-14 1971-08-02 Analogous process for the preparation of 3,21-dioxygenated 1,2α-methylene-6,7α-dihalomethylene-20-spirox-4-ene compounds.
DK590571AA DK127880C (en) 1969-05-14 1971-12-02 Analogous process for the preparation of 3-oxo-1,2α-methylene-dihalomethylene-20-spirox-4-ene compounds.

Country Status (17)

Country Link
JP (1) JPS532865B1 (en)
AR (1) AR192305A1 (en)
BE (1) BE750330A (en)
CA (1) CA926385A (en)
CH (2) CH547792A (en)
CS (2) CS151551B2 (en)
DE (1) DE2023450C3 (en)
DK (3) DK126992B (en)
FI (2) FI47355C (en)
FR (1) FR2051526B1 (en)
GB (1) GB1265444A (en)
IE (1) IE34194B1 (en)
IL (1) IL34431A (en)
NL (1) NL168844C (en)
NO (1) NO131131C (en)
SE (2) SE386904B (en)
YU (1) YU34052B (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3356677A (en) * 1966-04-05 1967-12-05 Syntex Corp 1alpha, 2alpha-and 6alpha, 7alpha-dihalomethylene androstenes

Also Published As

Publication number Publication date
FI47885C (en) 1974-04-10
IL34431A0 (en) 1970-07-19
FI47885B (en) 1974-01-02
IE34194L (en) 1970-11-14
DE2023450A1 (en) 1971-01-14
FI47355B (en) 1973-07-31
NL168844C (en) 1982-05-17
FI47355C (en) 1973-11-12
IE34194B1 (en) 1975-03-05
DK127505B (en) 1973-11-19
CH547785A (en) 1974-04-11
SE386904B (en) 1976-08-23
DE2023450C3 (en) 1979-05-31
BE750330A (en) 1970-11-13
CS151551B2 (en) 1973-10-19
JPS532865B1 (en) 1978-02-01
DK127880C (en) 1974-06-10
CH547792A (en) 1974-04-11
NL168844B (en) 1981-12-16
FR2051526A1 (en) 1971-04-09
DK127880B (en) 1974-01-28
NL7006474A (en) 1970-11-17
NO131131B (en) 1974-12-30
YU117670A (en) 1978-05-15
GB1265444A (en) 1972-03-01
SE366305B (en) 1974-04-22
DE2023450B2 (en) 1978-10-05
NO131131C (en) 1975-04-09
YU34052B (en) 1978-10-31
AR192305A1 (en) 1973-02-14
CA926385A (en) 1973-05-15
IL34431A (en) 1974-03-14
FR2051526B1 (en) 1974-04-12
CS151552B2 (en) 1973-10-19

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