FI4192814T3 - Transglutaminaasien estäjiä - Google Patents
Transglutaminaasien estäjiä Download PDFInfo
- Publication number
- FI4192814T3 FI4192814T3 FIEP22741488.5T FI22741488T FI4192814T3 FI 4192814 T3 FI4192814 T3 FI 4192814T3 FI 22741488 T FI22741488 T FI 22741488T FI 4192814 T3 FI4192814 T3 FI 4192814T3
- Authority
- FI
- Finland
- Prior art keywords
- oxo
- methyl
- carboxamido
- dihydropyridin
- oxoethyl
- Prior art date
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- 108060008539 Transglutaminase Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 102000003601 transglutaminase Human genes 0.000 title 1
- -1 bicyclo[1.1.1]pentyl Chemical group 0.000 claims 27
- GVNWZKBFMFUVNX-UHFFFAOYSA-N Adipamide Chemical compound NC(=O)CCCCC(N)=O GVNWZKBFMFUVNX-UHFFFAOYSA-N 0.000 claims 26
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 11
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 9
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 7
- 101150065749 Churc1 gene Proteins 0.000 claims 4
- 102100038239 Protein Churchill Human genes 0.000 claims 4
- SQVRNKJHWKZAKO-PFQGKNLYSA-N N-acetyl-beta-neuraminic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-PFQGKNLYSA-N 0.000 claims 3
- 241001024099 Olla Species 0.000 claims 3
- 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 claims 3
- 125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 claims 2
- GVNVAWHJIKLAGL-UHFFFAOYSA-N 2-(cyclohexen-1-yl)cyclohexan-1-one Chemical compound O=C1CCCCC1C1=CCCCC1 GVNVAWHJIKLAGL-UHFFFAOYSA-N 0.000 claims 2
- 208000013840 Non-involuting congenital hemangioma Diseases 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
- XRMDCWJNPDVAFI-UHFFFAOYSA-N 2,2,6,6-tetramethyl-1-oxopiperidin-1-ium-4-ol Chemical compound CC1(C)CC(O)CC(C)(C)[N+]1=O XRMDCWJNPDVAFI-UHFFFAOYSA-N 0.000 claims 1
- 101100204264 Arabidopsis thaliana STR4 gene Proteins 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- UYPRGHWGOBQCRO-GITDEKFASA-N CC(C)(C)NC(C(CC[C@@H](C(NC1=CC=CN(CC(NC2C3CC(C4)CC2CC4C3)=O)C1=O)=O)NC([C@H]1N(CC2)CCN2C1)=O)=O)=O Chemical compound CC(C)(C)NC(C(CC[C@@H](C(NC1=CC=CN(CC(NC2C3CC(C4)CC2CC4C3)=O)C1=O)=O)NC([C@H]1N(CC2)CCN2C1)=O)=O)=O UYPRGHWGOBQCRO-GITDEKFASA-N 0.000 claims 1
- YJBRBMHICPIMTA-LHHOIKMPSA-N CC1=C(C(N[C@@H](CCC(C(N)=O)=O)C(NC2=CC=CN(CC(NC3C4CC(C5)CC3CC5C4)=O)C2=O)=O)=O)SN=N1 Chemical compound CC1=C(C(N[C@@H](CCC(C(N)=O)=O)C(NC2=CC=CN(CC(NC3C4CC(C5)CC3CC5C4)=O)C2=O)=O)=O)SN=N1 YJBRBMHICPIMTA-LHHOIKMPSA-N 0.000 claims 1
- SVODJBBWODPRGF-YSNWRPKNSA-N CC1=C(C(N[C@@H](CCC(C(N)=O)=O)C(NC2=CC=CN(CC(N[C@H]3[C@@H](CC4)C[C@@H]4C3)=O)C2=O)=O)=O)OC2=C1C=CC=C2 Chemical compound CC1=C(C(N[C@@H](CCC(C(N)=O)=O)C(NC2=CC=CN(CC(N[C@H]3[C@@H](CC4)C[C@@H]4C3)=O)C2=O)=O)=O)OC2=C1C=CC=C2 SVODJBBWODPRGF-YSNWRPKNSA-N 0.000 claims 1
- GCCWUFNZAPGOHK-FDFQBQBKSA-N CC1=C(C(N[C@@H](CCC(C(NC)=O)=O)C(NC2=CC=CN(CC(NC3C(C4)C=CC4C3)=O)C2=O)=O)=O)OC2=C1C=CC=C2 Chemical compound CC1=C(C(N[C@@H](CCC(C(NC)=O)=O)C(NC2=CC=CN(CC(NC3C(C4)C=CC4C3)=O)C2=O)=O)=O)OC2=C1C=CC=C2 GCCWUFNZAPGOHK-FDFQBQBKSA-N 0.000 claims 1
- 125000006519 CCH3 Chemical group 0.000 claims 1
- DXLKVLIMXPIGHJ-AIPUEUPUSA-N CNC(C(CC[C@@H](C(NC1=CC=CN(CC(NC2C3CC(C4)CC2CC4C3)=O)C1=O)=O)NC(C(S1)=CC=C1Cl)=O)=O)=O Chemical compound CNC(C(CC[C@@H](C(NC1=CC=CN(CC(NC2C3CC(C4)CC2CC4C3)=O)C1=O)=O)NC(C(S1)=CC=C1Cl)=O)=O)=O DXLKVLIMXPIGHJ-AIPUEUPUSA-N 0.000 claims 1
- 101100065720 Caenorhabditis elegans ets-5 gene Proteins 0.000 claims 1
- 101100348008 Caenorhabditis elegans nas-2 gene Proteins 0.000 claims 1
- 208000015943 Coeliac disease Diseases 0.000 claims 1
- 235000008375 Decussocarpus nagi Nutrition 0.000 claims 1
- 244000309456 Decussocarpus nagi Species 0.000 claims 1
- 206010012468 Dermatitis herpetiformis Diseases 0.000 claims 1
- 101000988966 Escherichia coli Heat-stable enterotoxin A3/A4 Proteins 0.000 claims 1
- 208000010412 Glaucoma Diseases 0.000 claims 1
- 101500025412 Mus musculus Processed cyclic AMP-responsive element-binding protein 3-like protein 1 Proteins 0.000 claims 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims 1
- 240000007594 Oryza sativa Species 0.000 claims 1
- 235000007164 Oryza sativa Nutrition 0.000 claims 1
- 229930189345 Parkinsonin Natural products 0.000 claims 1
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 claims 1
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Natural products C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 claims 1
- 102000005871 S100 Calcium Binding Protein A7 Human genes 0.000 claims 1
- 108010005256 S100 Calcium Binding Protein A7 Proteins 0.000 claims 1
- 101150076149 TROL gene Proteins 0.000 claims 1
- 239000008186 active pharmaceutical agent Substances 0.000 claims 1
- QKSKPIVNLNLAAV-UHFFFAOYSA-N bis(2-chloroethyl) sulfide Chemical compound ClCCSCCCl QKSKPIVNLNLAAV-UHFFFAOYSA-N 0.000 claims 1
- 125000005518 carboxamido group Chemical group 0.000 claims 1
- 239000013256 coordination polymer Substances 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- 206010025135 lupus erythematosus Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- 235000001968 nicotinic acid Nutrition 0.000 claims 1
- 239000011664 nicotinic acid Substances 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 125000006238 prop-1-en-1-yl group Chemical group [H]\C(*)=C(/[H])C([H])([H])[H] 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 229940030793 psoriasin Drugs 0.000 claims 1
- 235000009566 rice Nutrition 0.000 claims 1
Classifications
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP21182956 | 2021-06-30 | ||
| EP21183316 | 2021-07-01 | ||
| US202163217783P | 2021-07-02 | 2021-07-02 | |
| PCT/EP2021/086674 WO2023110138A1 (en) | 2021-12-17 | 2021-12-17 | Inhibitors of transglutaminases |
| EP2022065435 | 2022-06-07 | ||
| PCT/EP2022/068217 WO2023275337A1 (en) | 2021-06-30 | 2022-06-30 | Inhibitors of transglutaminases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FI4192814T3 true FI4192814T3 (fi) | 2024-10-31 |
Family
ID=82547278
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FIEP22741488.5T FI4192814T3 (fi) | 2021-06-30 | 2022-06-30 | Transglutaminaasien estäjiä |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20240383856A1 (https=) |
| EP (1) | EP4192814B1 (https=) |
| JP (1) | JP2024524457A (https=) |
| KR (1) | KR20240028466A (https=) |
| CN (1) | CN117616011B (https=) |
| AU (1) | AU2022303109A1 (https=) |
| CL (1) | CL2023003921A1 (https=) |
| DK (1) | DK4192814T3 (https=) |
| ES (1) | ES2993597T3 (https=) |
| FI (1) | FI4192814T3 (https=) |
| HR (1) | HRP20241451T1 (https=) |
| HU (1) | HUE068724T2 (https=) |
| IL (1) | IL309476A (https=) |
| LT (1) | LT4192814T (https=) |
| MX (1) | MX2023015408A (https=) |
| PL (1) | PL4192814T3 (https=) |
| RS (1) | RS66080B1 (https=) |
| SI (1) | SI4192814T1 (https=) |
| WO (1) | WO2023275337A1 (https=) |
| ZA (1) | ZA202400821B (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2022301517A1 (en) * | 2021-06-30 | 2023-12-14 | Zedira Gmbh | Inhibitors of transglutaminases |
| JP7805983B2 (ja) | 2022-03-22 | 2026-01-26 | アッヴィ・インコーポレイテッド | ブルトン型チロシンキナーゼを分解するためのピリミジン |
| EP4637764A1 (en) | 2023-12-22 | 2025-10-29 | Zedira GmbH | Oxo-pyridine derivatives as inhibitors of transglutaminases for use in the treatment of pulmonary fibrosis |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006052755A1 (de) * | 2006-11-08 | 2008-05-15 | N-Zyme Biotec Gmbh | Michaelsysteme als Transglutaminaseinhibitoren |
| EP2687511A1 (de) | 2012-07-17 | 2014-01-22 | Zedira GmbH | Pyridinonderivate als Gewebetransglutaminaseinhibitoren |
| EP3342779A1 (en) * | 2016-12-27 | 2018-07-04 | Zedira GmbH | Inhibitors of transglutaminases |
| TWI825144B (zh) * | 2018-08-10 | 2023-12-11 | 美商思達利醫藥公司 | 第二型轉麩醯胺酸酶(tg2)抑制劑 |
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2022
- 2022-06-30 KR KR1020247003531A patent/KR20240028466A/ko active Pending
- 2022-06-30 EP EP22741488.5A patent/EP4192814B1/en active Active
- 2022-06-30 MX MX2023015408A patent/MX2023015408A/es unknown
- 2022-06-30 WO PCT/EP2022/068217 patent/WO2023275337A1/en not_active Ceased
- 2022-06-30 LT LTEPPCT/EP2022/068217T patent/LT4192814T/lt unknown
- 2022-06-30 AU AU2022303109A patent/AU2022303109A1/en active Pending
- 2022-06-30 PL PL22741488.5T patent/PL4192814T3/pl unknown
- 2022-06-30 DK DK22741488.5T patent/DK4192814T3/da active
- 2022-06-30 CN CN202280045224.7A patent/CN117616011B/zh active Active
- 2022-06-30 US US18/572,134 patent/US20240383856A1/en active Pending
- 2022-06-30 HU HUE22741488A patent/HUE068724T2/hu unknown
- 2022-06-30 HR HRP20241451TT patent/HRP20241451T1/hr unknown
- 2022-06-30 FI FIEP22741488.5T patent/FI4192814T3/fi active
- 2022-06-30 SI SI202230065T patent/SI4192814T1/sl unknown
- 2022-06-30 IL IL309476A patent/IL309476A/en unknown
- 2022-06-30 RS RS20241159A patent/RS66080B1/sr unknown
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- 2022-06-30 ES ES22741488T patent/ES2993597T3/es active Active
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2023
- 2023-12-28 CL CL2023003921A patent/CL2023003921A1/es unknown
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2024
- 2024-01-24 ZA ZA2024/00821A patent/ZA202400821B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2023015408A (es) | 2024-02-20 |
| CL2023003921A1 (es) | 2024-06-14 |
| AU2022303109A1 (en) | 2023-12-14 |
| ZA202400821B (en) | 2025-05-28 |
| HUE068724T2 (hu) | 2025-01-28 |
| CN117616011A (zh) | 2024-02-27 |
| SI4192814T1 (sl) | 2025-02-28 |
| CN117616011B (zh) | 2025-08-26 |
| EP4192814A1 (en) | 2023-06-14 |
| RS66080B1 (sr) | 2024-11-29 |
| HRP20241451T1 (hr) | 2025-01-17 |
| DK4192814T3 (da) | 2024-08-26 |
| JP2024524457A (ja) | 2024-07-05 |
| PL4192814T3 (pl) | 2024-12-23 |
| EP4192814B1 (en) | 2024-08-07 |
| US20240383856A1 (en) | 2024-11-21 |
| KR20240028466A (ko) | 2024-03-05 |
| WO2023275337A1 (en) | 2023-01-05 |
| LT4192814T (lt) | 2024-11-11 |
| IL309476A (en) | 2024-02-01 |
| ES2993597T3 (en) | 2025-01-02 |
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