FI20085101L - Procedure for Diagnosing Irritable Bowel Syndrome IBS - Google Patents

Procedure for Diagnosing Irritable Bowel Syndrome IBS Download PDF

Info

Publication number
FI20085101L
FI20085101L FI20085101A FI20085101A FI20085101L FI 20085101 L FI20085101 L FI 20085101L FI 20085101 A FI20085101 A FI 20085101A FI 20085101 A FI20085101 A FI 20085101A FI 20085101 L FI20085101 L FI 20085101L
Authority
FI
Finland
Prior art keywords
biomarkers
lipids
ibs
bowel syndrome
irritable bowel
Prior art date
Application number
FI20085101A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI20085101A0 (en
Inventor
Kajsa Kajander
Riitta Korpela
Original Assignee
Valio Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Valio Oy filed Critical Valio Oy
Priority to FI20085101A priority Critical patent/FI20085101L/en
Publication of FI20085101A0 publication Critical patent/FI20085101A0/en
Priority to PCT/FI2009/050089 priority patent/WO2009098354A1/en
Publication of FI20085101L publication Critical patent/FI20085101L/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7206—Mass spectrometers interfaced to gas chromatograph
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2405/00—Assays, e.g. immunoassays or enzyme assays, involving lipids
    • G01N2405/02—Triacylglycerols
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2405/00—Assays, e.g. immunoassays or enzyme assays, involving lipids
    • G01N2405/04—Phospholipids, i.e. phosphoglycerides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2405/00—Assays, e.g. immunoassays or enzyme assays, involving lipids
    • G01N2405/08—Sphingolipids

Abstract

Novel biomarkers associated with irritable bowel syndrome (IBS) have been found. The invention provides methods of diagnosing IBS by determining said biomarkers in samples taken from subjects suffering from the disease. Appropriate biomarkers includes certain lipids and/or certain non-lipid metabolites. Particularly suitable biomarkers are lipids involved in the metabolism of acylglycerol and sphingolipids, such as acylglycerols e.g. triacylglycerols (TG), and diacylglycerols (DG), glycerophospholipids, especially lysophospholipids such as lysophos- phatidylcholines (LysoPC) and lysophosphatidylethanolamines (LysoPE), and sphingolipids, especially ceramides (Cer) and glycosphingolipids (GlycoSL). A great number of lipids and/or water-soluble other metabolites may be determined simultaneously to obtain a metabolite profile of the subject.
FI20085101A 2008-02-05 2008-02-05 Procedure for Diagnosing Irritable Bowel Syndrome IBS FI20085101L (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FI20085101A FI20085101L (en) 2008-02-05 2008-02-05 Procedure for Diagnosing Irritable Bowel Syndrome IBS
PCT/FI2009/050089 WO2009098354A1 (en) 2008-02-05 2009-02-04 Method of diagnosing irritable bowel syndrome ibs

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FI20085101A FI20085101L (en) 2008-02-05 2008-02-05 Procedure for Diagnosing Irritable Bowel Syndrome IBS

Publications (2)

Publication Number Publication Date
FI20085101A0 FI20085101A0 (en) 2008-02-05
FI20085101L true FI20085101L (en) 2009-08-06

Family

ID=39148971

Family Applications (1)

Application Number Title Priority Date Filing Date
FI20085101A FI20085101L (en) 2008-02-05 2008-02-05 Procedure for Diagnosing Irritable Bowel Syndrome IBS

Country Status (2)

Country Link
FI (1) FI20085101L (en)
WO (1) WO2009098354A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5857503B2 (en) * 2010-07-29 2016-02-10 小野薬品工業株式会社 Biomarkers for stress-related diseases
WO2015125818A1 (en) * 2014-02-18 2015-08-27 小野薬品工業株式会社 Biomarker for diagnosis of irritable bowel syndrome
EP3149488B8 (en) 2014-03-28 2018-12-26 Dani Instruments S.p.A. Method for diagnosis of colorectal cancer by determining the level of fatty acids present in a biological fluid sample, and apparatus for implementing the method
CN104965043B (en) * 2015-07-02 2017-05-03 中山大学 Detection method of rice sphingolipid

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006031963A2 (en) * 2004-09-13 2006-03-23 Lipomics Technologies, Inc. Metabolite markers for weight management
PL2277524T3 (en) * 2005-09-28 2016-06-30 Nordic Rebalance As Treatment of IBS using both probiotic bacteria and fermented cereal as treatment effectors

Also Published As

Publication number Publication date
FI20085101A0 (en) 2008-02-05
WO2009098354A1 (en) 2009-08-13

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