FI20070005A - L-nucleosides for the treatment of hepatitis B virus and Epstein-Barr virus - Google Patents

L-nucleosides for the treatment of hepatitis B virus and Epstein-Barr virus Download PDF

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Publication number
FI20070005A
FI20070005A FI20070005A FI20070005A FI20070005A FI 20070005 A FI20070005 A FI 20070005A FI 20070005 A FI20070005 A FI 20070005A FI 20070005 A FI20070005 A FI 20070005A FI 20070005 A FI20070005 A FI 20070005A
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FI
Finland
Prior art keywords
fluoro
beta
virus
treatment
arabinofuranosyl
Prior art date
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FI20070005A
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Finnish (fi)
Swedish (sv)
Other versions
FI118954B (en
Inventor
Chung K Chu
Yung-Chi Cheng
Balakrishna S Pai
Gang-Qing Yao
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Univ Georgia
Univ Yale
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Application filed by Univ Georgia, Univ Yale filed Critical Univ Georgia
Publication of FI20070005A publication Critical patent/FI20070005A/en
Application granted granted Critical
Publication of FI118954B publication Critical patent/FI118954B/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

A method for the treatment of a host, and in particular, a human, infected with HBV or EBV is provided that includes administering an HBV- or EBV- treatment amount of an L-nucleoside of formula (I) <CHEM> wherein R is a purine or pyrimidine base. In one preferred embodiment, the active compound is 2'-fluoro-5-methyl- beta -L-arabinofuranosyluridine (also referred to as L-FMAU) This compound is a potent antiviral agent against HBV and EBV and exhibits low cytotoxicity. Other specific examples of active compounds include N1-(2'-deoxy-2'-fluoro- beta -L-arabinofuranosyl)-5-ethyluracil, N1-(2'-deoxy-2'-fluoro- beta -L-arabinofuranosyl)-5-iodocytosine), and N1-(2'-deoxy-2'-fluoro- beta -L-arabinofuranosyl)-5-iodouracil. <IMAGE>
FI20070005A 1994-01-28 2007-01-03 L-nucleosides for the treatment of hepatitis B virus and Epstein-Barr virus FI118954B (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/189,070 US5587362A (en) 1994-01-28 1994-01-28 L-nucleosides
US18907094 1994-01-28
US9501253 1995-01-30
PCT/US1995/001253 WO1995020595A1 (en) 1994-01-28 1995-01-30 L-nucleosides for the treatment of hepatitis b-virus and epstein-bar virus

Publications (2)

Publication Number Publication Date
FI20070005A true FI20070005A (en) 2007-01-03
FI118954B FI118954B (en) 2008-05-30

Family

ID=22695792

Family Applications (4)

Application Number Title Priority Date Filing Date
FI962986A FI117475B (en) 1994-01-28 1996-07-26 L-nucleosides for the treatment of hepatitis B virus and Epstein-Barr virus
FI20051033A FI119416B (en) 1994-01-28 2005-10-13 L-nucleosides for the treatment of hepatitis B virus and Epstein-Barr virus
FI20070005A FI118954B (en) 1994-01-28 2007-01-03 L-nucleosides for the treatment of hepatitis B virus and Epstein-Barr virus
FI20080432A FI121846B (en) 1994-01-28 2008-07-08 L-nucleosides for the treatment of hepatitis B virus and Epstein-Barr virus

Family Applications Before (2)

Application Number Title Priority Date Filing Date
FI962986A FI117475B (en) 1994-01-28 1996-07-26 L-nucleosides for the treatment of hepatitis B virus and Epstein-Barr virus
FI20051033A FI119416B (en) 1994-01-28 2005-10-13 L-nucleosides for the treatment of hepatitis B virus and Epstein-Barr virus

Family Applications After (1)

Application Number Title Priority Date Filing Date
FI20080432A FI121846B (en) 1994-01-28 2008-07-08 L-nucleosides for the treatment of hepatitis B virus and Epstein-Barr virus

Country Status (23)

Country Link
US (3) US5587362A (en)
EP (2) EP0748330B1 (en)
JP (1) JP3899440B2 (en)
KR (1) KR100321209B1 (en)
CN (1) CN1043769C (en)
AT (2) ATE236186T1 (en)
AU (1) AU710262B2 (en)
BG (1) BG62571B1 (en)
BR (1) BRPI9506596B8 (en)
CA (1) CA2182273C (en)
CZ (1) CZ292574B6 (en)
DE (2) DE69535047T2 (en)
DK (2) DK0748330T3 (en)
ES (2) ES2194902T3 (en)
FI (4) FI117475B (en)
HK (1) HK1014716A1 (en)
HU (1) HU228135B1 (en)
NO (1) NO306408B1 (en)
NZ (2) NZ330137A (en)
PT (2) PT748330E (en)
RO (1) RO116623B1 (en)
SK (1) SK285191B6 (en)
WO (1) WO1995020595A1 (en)

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