FI20021120A - Thermodynamically stable crystalline form of the benzoic acid salt of 4 "-deoxy-4" -epi-methylamino-avermectin B1a / B1b - Google Patents

Thermodynamically stable crystalline form of the benzoic acid salt of 4 "-deoxy-4" -epi-methylamino-avermectin B1a / B1b Download PDF

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Publication number
FI20021120A
FI20021120A FI20021120A FI20021120A FI20021120A FI 20021120 A FI20021120 A FI 20021120A FI 20021120 A FI20021120 A FI 20021120A FI 20021120 A FI20021120 A FI 20021120A FI 20021120 A FI20021120 A FI 20021120A
Authority
FI
Finland
Prior art keywords
epi
deoxy
benzoic acid
acid salt
crystalline form
Prior art date
Application number
FI20021120A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI111165B (en
Inventor
Raymond Cvetovich
Richard Demchak
James Mccauley
Richard J Varsalona
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of FI20021120A publication Critical patent/FI20021120A/en
Application granted granted Critical
Publication of FI111165B publication Critical patent/FI111165B/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Environmental Sciences (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Abstract

The most thermodynamically stable crystalline form of the benzoic acid salt of 4"-deoxy-4"-epi-methylamino avermectin B1a/B1b as the hemihydrate is obtained by crystallization from organic solvents containing a controlled amount of water.
FI20021120A 1993-08-19 2002-06-11 Thermodynamically stable crystal form of 4 "-deoxy-4" epimethylaminoavermectin B1a / B1b benzoic acid salt, process for its preparation and use FI111165B (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US10918993A 1993-08-19 1993-08-19
US10918993 1993-08-19
US9409207 1994-08-15
PCT/US1994/009207 WO1995005390A1 (en) 1993-08-19 1994-08-15 THERMODYNAMICALLY STABLE CRYSTAL FORM OF 4'-DEOXY-4'-EPI-METHYLAMINO AVERMECTIN B1a/B1b BENZOIC ACID SALT AND PROCESSES FOR ITS PREPARATION

Publications (2)

Publication Number Publication Date
FI20021120A true FI20021120A (en) 2002-06-11
FI111165B FI111165B (en) 2003-06-13

Family

ID=22326282

Family Applications (2)

Application Number Title Priority Date Filing Date
FI960725A FI110783B (en) 1993-08-19 1996-02-16 A process for the preparation of the crystalline compound 4 "-deoxy-4" -epimethylamino-avermectin B1a / B1b benzoic acid salt hemihydrate (type B) useful as a medicament
FI20021120A FI111165B (en) 1993-08-19 2002-06-11 Thermodynamically stable crystal form of 4 "-deoxy-4" epimethylaminoavermectin B1a / B1b benzoic acid salt, process for its preparation and use

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FI960725A FI110783B (en) 1993-08-19 1996-02-16 A process for the preparation of the crystalline compound 4 "-deoxy-4" -epimethylamino-avermectin B1a / B1b benzoic acid salt hemihydrate (type B) useful as a medicament

Country Status (25)

Country Link
EP (1) EP0714400B1 (en)
JP (3) JP3954093B2 (en)
KR (1) KR100370697B1 (en)
CN (1) CN1041523C (en)
AT (1) ATE187735T1 (en)
AU (1) AU684828B2 (en)
BR (1) BR9407300A (en)
CA (1) CA2168843C (en)
CY (1) CY2181B1 (en)
CZ (1) CZ287929B6 (en)
DE (1) DE69422182T2 (en)
DK (1) DK0714400T3 (en)
ES (1) ES2139753T3 (en)
FI (2) FI110783B (en)
GR (1) GR3032164T3 (en)
HU (1) HU217769B (en)
LV (1) LV12571B (en)
NO (1) NO305658B1 (en)
NZ (1) NZ273129A (en)
PL (1) PL176300B1 (en)
PT (1) PT714400E (en)
RU (1) RU2133753C1 (en)
SK (1) SK281684B6 (en)
WO (1) WO1995005390A1 (en)
ZA (1) ZA946203B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6486195B1 (en) * 1993-08-19 2002-11-26 Merck & Co., Inc. Thermodynamically stable crystal form of 4″-deoxy-4″-epi-methylamino avermectin B1a/B1b benzoic acid salt and processes for its preparation
CR6574A (en) 2001-02-27 2004-10-28 Syngenta Participations Ag SALTS OF SUBSTITUTED FINDINGS IN POSITION 4 WITH PESTICIATED PROPERTIES
CA2790921A1 (en) * 2010-02-23 2011-09-01 Nippon Kayaku Co., Ltd. Stabilized crystal of 2-ethyl-3,7-dimethyl-6-(4-(trifluoromethoxy)phenoxy)quinoline-4-yl methyl carbonate, process for producing the crystal, and agricultural chemical compositioncomprising the crystal
CN106995476B (en) * 2017-05-16 2018-03-13 河北美荷药业有限公司 A kind of preparation method of emamectin benzoate B2 benzoates
CN108840893A (en) * 2018-07-01 2018-11-20 李万强 A kind of novel crystal forms of emamectin-benzoate and preparation method thereof
CN109912671B (en) * 2019-04-12 2022-04-26 宁夏泰益欣生物科技有限公司 Method for extracting abamectin B2a by using abamectin crystallization mother liquor

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57212200A (en) * 1981-06-23 1982-12-27 Takeda Chem Ind Ltd Preparation of echinoside a
GB8518422D0 (en) * 1985-07-22 1985-08-29 Beecham Group Plc Compounds
IT1216059B (en) * 1988-03-11 1990-02-22 Crc Ricerca Chim PROCEDURE FOR THE SEPARATION OF MACROCYCLIC DIASTEREOMERS.
JPH0631302B2 (en) * 1988-11-16 1994-04-27 日本化薬株式会社 Etoposide-2-dimethylamino form hydrochloric acid dihydrate crystal and process for producing the same
JPH0615557B2 (en) * 1990-02-19 1994-03-02 ヤマサ醤油株式会社 2'-deoxy-2'-methylidene cytidine dihydrate crystal
JPH0446192A (en) * 1990-06-12 1992-02-17 Nippon Kayaku Co Ltd Oxetanocin g anhydride crystal and production thereof
IL98599A (en) * 1990-06-28 1995-06-29 Merck & Co Inc Stable salts of 4"-deoxy-4"-epi-methylamino avermectin b1a/b1b and insecticidal compositions containing them
JP2652272B2 (en) * 1990-12-31 1997-09-10 住化ファインケム株式会社 Novel crystal of 1- (4-amino-6,7-dimethoxy-2-quinazolinyl) -4- (2-tetrahydrofuroyl) piperazine hydrochloride and a method for producing the crystal
EP0590150B1 (en) * 1991-05-15 1998-07-08 Yamanouchi Pharmaceutical Co. Ltd. (-)-(s)-2,8-dimethyl-3-methylene-1-oxa-8-azaspiro 4,5]decane l-tartrate
JP2848721B2 (en) * 1991-08-09 1999-01-20 森永乳業株式会社 Crystal lactulose trihydrate and its production

Also Published As

Publication number Publication date
CN1129453A (en) 1996-08-21
RU2133753C1 (en) 1999-07-27
DE69422182T2 (en) 2000-06-21
EP0714400B1 (en) 1999-12-15
PL313043A1 (en) 1996-05-27
NO305658B1 (en) 1999-07-05
PL176300B1 (en) 1999-05-31
FI111165B (en) 2003-06-13
JP3954093B2 (en) 2007-08-08
HU9600345D0 (en) 1996-04-29
WO1995005390A1 (en) 1995-02-23
GR3032164T3 (en) 2000-04-27
HUT73552A (en) 1996-08-28
CY2181B1 (en) 2002-08-23
JP2011207899A (en) 2011-10-20
NO960618D0 (en) 1996-02-16
CZ287929B6 (en) 2001-03-14
DK0714400T3 (en) 2000-04-10
CA2168843C (en) 2004-10-19
SK20996A3 (en) 1996-06-05
FI110783B (en) 2003-03-31
EP0714400A1 (en) 1996-06-05
LV12571A (en) 2000-11-20
AU684828B2 (en) 1998-01-08
JP2007176946A (en) 2007-07-12
DE69422182D1 (en) 2000-01-20
CN1041523C (en) 1999-01-06
FI960725A (en) 1996-02-16
CA2168843A1 (en) 1995-02-23
CZ45996A3 (en) 1996-05-15
PT714400E (en) 2000-05-31
LV12571B (en) 2001-04-20
KR960703936A (en) 1996-08-31
ES2139753T3 (en) 2000-02-16
KR100370697B1 (en) 2003-06-11
BR9407300A (en) 1996-10-08
AU7631994A (en) 1995-03-14
SK281684B6 (en) 2001-06-11
NO960618L (en) 1996-02-16
ZA946203B (en) 1995-03-31
NZ273129A (en) 1996-08-27
HU217769B (en) 2000-04-28
JPH09502169A (en) 1997-03-04
ATE187735T1 (en) 2000-01-15
FI960725A0 (en) 1996-02-16

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Owner name: MERCK SHARP & DOHME CORP.

Free format text: MERCK SHARP & DOHME CORP.

PC Transfer of assignment of patent

Owner name: MERCK SHARP & DOHME CORP.

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