FI20011207A - A process for the preparation of therapeutically useful tricyclic diazepines - Google Patents
A process for the preparation of therapeutically useful tricyclic diazepines Download PDFInfo
- Publication number
- FI20011207A FI20011207A FI20011207A FI20011207A FI20011207A FI 20011207 A FI20011207 A FI 20011207A FI 20011207 A FI20011207 A FI 20011207A FI 20011207 A FI20011207 A FI 20011207A FI 20011207 A FI20011207 A FI 20011207A
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- FI
- Finland
- Prior art keywords
- opt
- substd
- satd
- membered aromatic
- preparation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Reproductive Health (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Tricyclic diazepine derivs. of formula (I) and their pharmaceutically acceptable salts, esters and pro-drugs are new. Y = (CH2)n, CH(1-3 C alkyl) or CO; AB = (CH2)mN(R3) or N(R3)(CH2)m ; n = 0-2; m = 1-2; provided that when Y = (CH2)n and n = 2, m may also be 0, and when n = 0, m may also be 3, provided also that when Y = (CH2)n and n = 2, m is not 2; R3 = COAr; Ar = substd. phenyl; opt. N-substd. indole; or opt. substd. furan, thiophene or pyrrole; D, E, F = C or N, any C atoms being opt. substd.; Z is such that the ring contg. it = opt. substd. fused phenyl; 5-membered aromatic, opt. satd. ring contg. one of O, N and S; 6-membered aromatic, opt. satd. ring contg. one N; 5- or 6-membered aromatic, opt. satd. ring contg. two N; or 5-membered aromatic, opt. satd. ring contg. one N, and either one O or one S; the heterocyclic rings are opt. substd.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI20011207A FI113868B (en) | 1993-07-29 | 2001-06-07 | Tri:cyclic diazepine derivs. - act as non-peptide vasopressin and oxytocin antagonists, used to treat e.g. congestive heart failure and liver cirrhosis |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10000493A | 1993-07-29 | 1993-07-29 | |
US10000493 | 1993-07-29 | ||
FI20011207 | 2001-06-07 | ||
FI20011207A FI113868B (en) | 1993-07-29 | 2001-06-07 | Tri:cyclic diazepine derivs. - act as non-peptide vasopressin and oxytocin antagonists, used to treat e.g. congestive heart failure and liver cirrhosis |
Publications (2)
Publication Number | Publication Date |
---|---|
FI20011207A true FI20011207A (en) | 2001-06-07 |
FI113868B FI113868B (en) | 2004-06-30 |
Family
ID=22277643
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI943543A FI110944B (en) | 1993-07-29 | 1994-07-28 | Process for the preparation of therapeutically useful pyrrolo, pyrazolo and imidazo [2,1-c] [1,4] diazepines |
FI20011207A FI113868B (en) | 1993-07-29 | 2001-06-07 | Tri:cyclic diazepine derivs. - act as non-peptide vasopressin and oxytocin antagonists, used to treat e.g. congestive heart failure and liver cirrhosis |
FI20011206A FI113867B (en) | 1993-07-29 | 2001-06-07 | A process for the preparation of therapeutically useful pyrrolo [1,2-a] quinoxaline |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI943543A FI110944B (en) | 1993-07-29 | 1994-07-28 | Process for the preparation of therapeutically useful pyrrolo, pyrazolo and imidazo [2,1-c] [1,4] diazepines |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI20011206A FI113867B (en) | 1993-07-29 | 2001-06-07 | A process for the preparation of therapeutically useful pyrrolo [1,2-a] quinoxaline |
Country Status (29)
Country | Link |
---|---|
US (2) | US5516774A (en) |
EP (1) | EP0636625B1 (en) |
JP (1) | JP3782475B2 (en) |
KR (1) | KR100347479B1 (en) |
CN (2) | CN1039908C (en) |
AT (1) | ATE176234T1 (en) |
AU (1) | AU683660B2 (en) |
BR (1) | BR1100563A (en) |
CA (1) | CA2128956C (en) |
CZ (1) | CZ291322B6 (en) |
DE (1) | DE69416211T2 (en) |
DK (1) | DK0636625T3 (en) |
EC (1) | ECSP941137A (en) |
ES (1) | ES2129090T3 (en) |
FI (3) | FI110944B (en) |
GR (1) | GR3030069T3 (en) |
HK (1) | HK1011363A1 (en) |
HU (1) | HU220707B1 (en) |
IL (1) | IL110435A (en) |
LV (1) | LV12497B (en) |
NO (1) | NO301827B1 (en) |
NZ (1) | NZ264115A (en) |
PE (1) | PE17895A1 (en) |
PH (1) | PH31469A (en) |
PL (1) | PL178563B1 (en) |
RU (1) | RU2126006C1 (en) |
SG (1) | SG47522A1 (en) |
SK (1) | SK280836B6 (en) |
ZA (1) | ZA945603B (en) |
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-
1994
- 1994-06-13 US US08/254,822 patent/US5516774A/en not_active Expired - Lifetime
- 1994-07-15 SG SG1996002643A patent/SG47522A1/en unknown
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- 1994-07-15 AT AT94111039T patent/ATE176234T1/en active
- 1994-07-15 DK DK94111039T patent/DK0636625T3/en active
- 1994-07-15 DE DE69416211T patent/DE69416211T2/en not_active Expired - Lifetime
- 1994-07-20 SK SK881-94A patent/SK280836B6/en not_active IP Right Cessation
- 1994-07-25 IL IL11043594A patent/IL110435A/en not_active IP Right Cessation
- 1994-07-26 PE PE1994247526A patent/PE17895A1/en not_active Application Discontinuation
- 1994-07-26 CZ CZ19941799A patent/CZ291322B6/en not_active IP Right Cessation
- 1994-07-27 PH PH48700A patent/PH31469A/en unknown
- 1994-07-27 CA CA002128956A patent/CA2128956C/en not_active Expired - Fee Related
- 1994-07-28 NO NO942816A patent/NO301827B1/en not_active IP Right Cessation
- 1994-07-28 NZ NZ264115A patent/NZ264115A/en not_active IP Right Cessation
- 1994-07-28 HU HU9402219A patent/HU220707B1/en not_active IP Right Cessation
- 1994-07-28 AU AU68777/94A patent/AU683660B2/en not_active Ceased
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- 1994-07-28 FI FI943543A patent/FI110944B/en not_active IP Right Cessation
- 1994-07-28 EC EC1994001137A patent/ECSP941137A/en unknown
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- 1994-07-28 RU RU94027583A patent/RU2126006C1/en not_active IP Right Cessation
- 1994-07-29 PL PL94304498A patent/PL178563B1/en not_active IP Right Cessation
- 1994-07-29 CN CN94108769A patent/CN1039908C/en not_active Expired - Fee Related
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1995
- 1995-06-06 US US08/468,737 patent/US5624923A/en not_active Expired - Lifetime
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1997
- 1997-05-13 BR BR1100563-7A patent/BR1100563A/en active IP Right Grant
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1998
- 1998-02-10 CN CN98103834A patent/CN1056374C/en not_active Expired - Fee Related
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1999
- 1999-04-26 GR GR990401154T patent/GR3030069T3/en unknown
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2000
- 2000-01-27 LV LVP-00-13A patent/LV12497B/en unknown
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2001
- 2001-06-07 FI FI20011207A patent/FI113868B/en not_active IP Right Cessation
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