FI20010553A - Angusykliinin biosynteesin geeniryhmittymä ja sen käyttö yhdisteiden tuottamiseksi lääkeaineseulontaa varten - Google Patents

Angusykliinin biosynteesin geeniryhmittymä ja sen käyttö yhdisteiden tuottamiseksi lääkeaineseulontaa varten Download PDF

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Publication number
FI20010553A
FI20010553A FI20010553A FI20010553A FI20010553A FI 20010553 A FI20010553 A FI 20010553A FI 20010553 A FI20010553 A FI 20010553A FI 20010553 A FI20010553 A FI 20010553A FI 20010553 A FI20010553 A FI 20010553A
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FI
Finland
Prior art keywords
angus
cyclin
compounds
production
drug screening
Prior art date
Application number
FI20010553A
Other languages
English (en)
Swedish (sv)
Other versions
FI20010553A0 (fi
FI111270B (fi
Inventor
Kaisa Palmu
Tero Kunnari
Original Assignee
Galilaeus Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galilaeus Oy filed Critical Galilaeus Oy
Priority to FI20010553A priority Critical patent/FI111270B/fi
Publication of FI20010553A0 publication Critical patent/FI20010553A0/fi
Priority to EP02706805A priority patent/EP1370578A1/en
Priority to PCT/FI2002/000214 priority patent/WO2002074800A1/en
Priority to JP2002573808A priority patent/JP2004537281A/ja
Priority to CA002441275A priority patent/CA2441275A1/en
Priority to US10/469,442 priority patent/US20050089954A1/en
Publication of FI20010553A publication Critical patent/FI20010553A/fi
Application granted granted Critical
Publication of FI111270B publication Critical patent/FI111270B/fi

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/26—Quinones containing groups having oxygen atoms singly bound to carbon atoms
    • C07C50/36—Quinones containing groups having oxygen atoms singly bound to carbon atoms the quinoid structure being part of a condensed ring system having four or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P15/00—Preparation of compounds containing at least three condensed carbocyclic rings

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
FI20010553A 2001-03-19 2001-03-19 Angusykliinien biosynteesin geeniryhmittymä ja sen käyttö yhdisteiden tuottamiseksi lääkeaineseulontaa varten FI111270B (fi)

Priority Applications (6)

Application Number Priority Date Filing Date Title
FI20010553A FI111270B (fi) 2001-03-19 2001-03-19 Angusykliinien biosynteesin geeniryhmittymä ja sen käyttö yhdisteiden tuottamiseksi lääkeaineseulontaa varten
EP02706805A EP1370578A1 (en) 2001-03-19 2002-03-15 Gene cluster for rabelomycin biosynthesis and its use to generate compounds for drug screening
PCT/FI2002/000214 WO2002074800A1 (en) 2001-03-19 2002-03-15 Gene cluster for rabelomycin biosynthesis and its use to generate compounds for drug screening
JP2002573808A JP2004537281A (ja) 2001-03-19 2002-03-15 レベロマイシンの生合成に関与する遺伝子クラスターおよびドラッグスクリーニング用化合物の製造にそれを用いる方法
CA002441275A CA2441275A1 (en) 2001-03-19 2002-03-15 Gene cluster for rabelomycin biosynthesis and its use to generate compounds for drug screening
US10/469,442 US20050089954A1 (en) 2001-03-19 2002-03-15 Gene cluster for rabelomycin biosynthesis and its use to generate compounds for drug screening

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI20010553 2001-03-19
FI20010553A FI111270B (fi) 2001-03-19 2001-03-19 Angusykliinien biosynteesin geeniryhmittymä ja sen käyttö yhdisteiden tuottamiseksi lääkeaineseulontaa varten

Publications (3)

Publication Number Publication Date
FI20010553A0 FI20010553A0 (fi) 2001-03-19
FI20010553A true FI20010553A (fi) 2002-09-20
FI111270B FI111270B (fi) 2003-06-30

Family

ID=8560780

Family Applications (1)

Application Number Title Priority Date Filing Date
FI20010553A FI111270B (fi) 2001-03-19 2001-03-19 Angusykliinien biosynteesin geeniryhmittymä ja sen käyttö yhdisteiden tuottamiseksi lääkeaineseulontaa varten

Country Status (6)

Country Link
US (1) US20050089954A1 (fi)
EP (1) EP1370578A1 (fi)
JP (1) JP2004537281A (fi)
CA (1) CA2441275A1 (fi)
FI (1) FI111270B (fi)
WO (1) WO2002074800A1 (fi)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2331397B1 (es) * 2008-03-28 2010-10-21 Universidad De Oviedo Derivados de oviedomicina, su procedimiento de obtencion y sus usos.
CN102492006B (zh) * 2011-12-14 2013-12-25 中国科学院南海海洋研究所 一类角环素类化合物及其在制备抗肿瘤药物中的应用
CN104744533B (zh) * 2015-01-30 2017-08-25 中国科学院南海海洋研究所 一类角环素化合物及其在制备抗肿瘤或抗菌药物中的应用
CN107164394B (zh) * 2017-03-10 2020-08-11 中国科学院南海海洋研究所 一种非典型角环素类化合物nenestatin A的生物合成基因簇及其应用
CN110585443A (zh) * 2019-09-04 2019-12-20 中国人民解放军陆军军医大学第一附属医院 一种抑制胶质瘤侵袭性生长的复合物及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3721684A (en) * 1970-06-18 1973-03-20 Squibb & Sons Inc Rabelomycin
ES2164713T3 (es) * 1993-09-20 2002-03-01 Univ Leland Stanford Junior Produccion recombinante de nuevos poliquetidos.
FI107053B (fi) * 1998-10-23 2001-05-31 Galilaeus Oy Nogalamysiinin biosynteesiin liittyvä geeniryhmittymä ja sen käyttö hybridiantibioottien tuotossa

Also Published As

Publication number Publication date
WO2002074800A1 (en) 2002-09-26
EP1370578A1 (en) 2003-12-17
US20050089954A1 (en) 2005-04-28
FI20010553A0 (fi) 2001-03-19
CA2441275A1 (en) 2002-09-26
FI111270B (fi) 2003-06-30
JP2004537281A (ja) 2004-12-16

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