FI122095B - Resin solution used in the preparation of ointment - Google Patents

Description

The present invention relates to a solution / product mixture of softwood pitch and alcohol in the form of claim 1, which can be used for the preparation of a pitch containing ointment.

Resin solution for latch manufacture

In folk medicine for skin wounds and skin infections, resin boiled in animal fat 5 has been a tradition for centuries in Finland and the Nordic countries. Recent studies show that such a conventional and conventionally made ointment has proven effective in the treatment of skin wounds in a randomized clinical trial. The ointment has clear antimicrobial properties, at least in the so-called skin. against pathogenic Gram-positive bacteria (1,2).

The traditional production of resinous lime is by heating and boiling the resin harvested or flushed from conifers (usually 10 spruce; Picea abies) into butter or pig skin, after which the fat which has been heated and obtained by heating is filtered, cooled and used as an ointment.

Spruce or pine resin is a mixture of many different chemical substances, with the main constituents being a large number of different biologically active diterpenes and lignans, along with several volatile compounds. In traditional resin preparation, heating and boiling alter the structure of the resin and the fatty chemical compounds in a manner that cannot be predicted or controlled.

As a result, carcinogenic products may be produced - cf. manufacture of tar in heated tar tombs, etc. For this reason, among others, restrictions, prohibitions and warnings have been placed on the use of tar products by the authorities.

The present invention is a liquid resin mixture, not prepared by heating or heating, which does not contain carcinogenic and altered abnormal compounds resulting from heating. The invention is a solution which, for example, can be used as a raw material in the manufacture of a resin with no impurities or problems caused by heating. The invention is a solution-alcohol-pitch mixture in which the pitch content of the mixture can further be controlled and accurately measured.

^ It is a mixture in which all the "natural" and biologically active ingredients of the resin are unchanged. The solution is used as a raw material and further mixed with other substances, such as drugs, formulated fat bases and substances which are soluble in alcohol.

The solution is also used directly as a protective agent and coating for various surfaces.

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The solution (mixture) according to the invention is obtained by dissolving the collected or flowed resin (conifer, pine, etc.) pitch in alcohol for various lengths of time (from day to several weeks), after which the resulting solution is filtered. The solution is not heated at any stage of the preparation.

More specifically, the resin solution / mixture is prepared in a sealed container at room temperature (+ 16 5 ... 25 ° C). The solution is obtained by placing a concentrated alcoholic solution (e.g.

denatured concentrated alcohol or the like) and to the solution is added the crude or collected crude resin collected or drained in the desired ratio (usually 1: 1 by weight). The mixture is kept in a sealed container at room temperature for several days, if necessary for 2-6 weeks, after which it is cleaned of debris etc. by filtration and straining. The mixture is stirred either continuously or at 10 times (e.g. once daily) to promote dissolution. Over several days or weeks, a fluid solution is obtained which raises the pitch to 60% by weight (the pitch can be measured by weighing the weight of the alcohol solution before and after evaporation of the alcohol). The resin content of the solution is the difference between the weight measurements relative to the volume or weight of the solution used in the measurement.

According to the idea of the invention, the alcohol-soluble resin components of biological and antimicrobial activity, diterpenes and lignans, at the same physiological relative concentrations as pure resin. From the purified resin, the resin solution according to the invention, and the fat blends made from it, small amounts of the biologically active compounds (diterpenes and lignans) of the resin dissolve in the aqueous phase. This can be detected by gas chromatography (Gas-Liquid-20 Chromatography / GLC) measurement (Figure 1). According to the Ames test, the solution or the ointment made from it does not show genotoxicity (Figure 2).

The solution of the invention is fluid at room temperature. The solution can be poured, brushed, sprayed or drained onto a desired surface or container.

The solution according to the invention is a mixture which can be mixed (dissolved) with another other ingredient (eg ointment, grease, liquid, etc.) whereby all the constituents of the resin o are mixed in said second substance in natural proportions and at concentrations pre-mixed. precisely defined.

The resin solution can also be prepared as described above using other solvents (acetone, ether, chloroform, etc.).

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References: 1. Sipponen A et al., A Beneficial Effect of Resin Salve in the Treatment of Severe Pressure Ulcers: A Prospective, Randomized and Controlled Multicenter Trial. Br J Dermatol 2008; 158: 1055-62

2. Antimicrobial effects of home-made resin salve from Norway spruce by Rautio M et al. APM1S

5 2007; 115: 335-40 δ

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Claims (3)

1. Product consisting of a mixture of softwood rosin (rosin) and alcohol of 1% to 60% (by weight) obtained by dissolving the collected or drained coniferous crude alcohol in the alcohol without heating and after filtration it has been filtered at room temperature (+ 16-25 ° C). Use of the product of claim 1 as a raw material for preparing fat-based ointments, sprays or solutions by mixing the solution in the desired proportions with a known fat, solid, drug or solution at room temperature without heating the mixture. Use of the product according to claim 1 as an anti-rot and impregnating agent. δ CM i m o o X cc Q- LO CM CO O 00 O O CM