FI122095B - Resin solution used in the preparation of ointment - Google Patents
Resin solution used in the preparation of ointment Download PDFInfo
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Description
Tämän keksinnön kohteena on patenttivaatimuksen 1 mukainen liuosmuodossa oleva havupuun pihkan ja alkoholin seos/tuote, jota voidaan käyttää pihkaa sisältävän rasvasalvan valmistukseen.The present invention relates to a solution / product mixture of softwood pitch and alcohol in the form of claim 1, which can be used for the preparation of a pitch containing ointment.
Salvan valmistuksessa käytettävä pihkaliuosResin solution for latch manufacture
Ihohaavojen ja ihoinfektioiden kansanlääkinnässä eläinrasvaan keitetty kuusen pihka (pihkasalva) on 5 ollut vuosisatoja perinne Suomessa ja Pohjoismaissa. Uusimpien tutkimusten mukaan tällainen perinteinen ja perinteisesti valmistettu salva on kliinisessä satunnaistetussa kokeessa osoittautunut tehokkaaksi ihohaavojen hoidossa. Salvalla on selkeät antimikrobiset ominaisuudet, ainakin ihon ns. patogeenisiä Gram-positiivisia bakteereita vastaan (1,2).In folk medicine for skin wounds and skin infections, resin boiled in animal fat 5 has been a tradition for centuries in Finland and the Nordic countries. Recent studies show that such a conventional and conventionally made ointment has proven effective in the treatment of skin wounds in a randomized clinical trial. The ointment has clear antimicrobial properties, at least in the so-called skin. against pathogenic Gram-positive bacteria (1,2).
Pihkasalvan perinteinen valmistus tapahtuu kuumentamalla ja keittämällä havupuista (tavallisesti 10 kuusi; Picea abies) kerätty tai juoksutettu pihka voihin tai sian ihraan, jonka jälkeen kuumennettu ja kuumentamalla juoksevaksi saatu rasva on suodatettu, jäähdytetty, ja käytetty salvana.The traditional production of resinous lime is by heating and boiling the resin harvested or flushed from conifers (usually 10 spruce; Picea abies) into butter or pig skin, after which the fat which has been heated and obtained by heating is filtered, cooled and used as an ointment.
Kuusen tai männyn pihka on monen eri kemiallisen aineen seos, jossa pääaineosat ovat suuri määrä erilaisia biologisesti aktiivisia diterpeenejä ja lignaaneja, useiden haihtuvien yhdisteiden ohella. Perinteisessä pihkaseoksen valmistuksessa kuumentaminen ja keittäminen muuttavat pihkan ja 15 rasvan kemiallisten yhdisteiden rakennetta tavalla, jota ei pysty ennustamaan tai hallitsemaan.Spruce or pine resin is a mixture of many different chemical substances, with the main constituents being a large number of different biologically active diterpenes and lignans, along with several volatile compounds. In traditional resin preparation, heating and boiling alter the structure of the resin and the fatty chemical compounds in a manner that cannot be predicted or controlled.
Seurauksena voi syntyä karsinogeenisia tuotteita - vrt. tervan valmistus kuumennetuissa tervahaudoissa ym. Muun muassa tästä syystä tervatuotteiden käyttöön on asetettu viranomaistaholta rajoituksia, kieltoja ja varoituksia.As a result, carcinogenic products may be produced - cf. manufacture of tar in heated tar tombs, etc. For this reason, among others, restrictions, prohibitions and warnings have been placed on the use of tar products by the authorities.
Tämä keksintö on nestemäinen pihkaseos, joka ei ole valmistettu kuumentamalla tai lämmittämällä, 2Ö ja jossa kuumentamisen vuoksi syntyneitä karsinogeenisia ja muuttuneita poikkeavia yhdisteitä ei ole. Keksintö on liuos, jota esimerkiksi voidaan käyttää raaka-aineena valmistettaessa pihkasalvaa, jossa kuumentamisesta aiheutuvia epäpuhtauksia tai ongelmia ei ole. Keksintö on liuosmainen alkoholi-pihka-seos, jossa seoksen pihkapitoisuutta voidaan lisäksi säädellä ja täsmällisesti mitata.The present invention is a liquid resin mixture, not prepared by heating or heating, which does not contain carcinogenic and altered abnormal compounds resulting from heating. The invention is a solution which, for example, can be used as a raw material in the manufacture of a resin with no impurities or problems caused by heating. The invention is a solution-alcohol-pitch mixture in which the pitch content of the mixture can further be controlled and accurately measured.
^ Kyseessä on seos, jossa kaikki pihkan "luonnolliset" ja biologisesti vaikuttavat ainesosat ovat c\i i 25 muuttumattomina. Liuosta käytetään raaka-aineena ja sekoitetaan edelleen muihin aineisiin, o ^ esimerkiksi sellaisiin lääkkeisiin, formuloituihin rasvapohjiin ja aineisiin, jotka liukenevat alkoholiin.^ It is a mixture in which all the "natural" and biologically active ingredients of the resin are unchanged. The solution is used as a raw material and further mixed with other substances, such as drugs, formulated fat bases and substances which are soluble in alcohol.
Liuosta käytetään myös sellaisenaan erilaisten pintojen suoja-aineena ja pinnoitteena.The solution is also used directly as a protective agent and coating for various surfaces.
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^ Täsmällisemmin sanottuna keksinnön mukaiselle liuokselle on tunnusomaista se, mikä on esitettyMore specifically, the solution of the invention is characterized by what is shown
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g patenttivaatimuksen tunnusmerkkiosassa.g in the claim part.
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22
Keksinnön mukainen liuos (seos) saadaan aikaan liuottamalla kerätty tai juoksutettu havupuun (kuusi, mänty, jne.) pihka alkoholissa eripituisia aikoja (päivästä useisiin viikkoihin), jonka jälkeen saatu liuos suodatetaan. Liuosta ei missään valmistusvaiheessa kuumenneta.The solution (mixture) according to the invention is obtained by dissolving the collected or flowed resin (conifer, pine, etc.) pitch in alcohol for various lengths of time (from day to several weeks), after which the resulting solution is filtered. The solution is not heated at any stage of the preparation.
Tarkemmin kuvattuna, pihkaliuos/seos valmistetaan suljetussa astiassa huoneen lämmössä (+16 5 ...25°C). Liuos saadaan aikaan siten, että suljettuun astiaan laitetaan väkevä alkoholiliuos (esim.More specifically, the resin solution / mixture is prepared in a sealed container at room temperature (+ 16 5 ... 25 ° C). The solution is obtained by placing a concentrated alcoholic solution (e.g.
denaturoitu väkevä alkoholi tai vastaava) ja liuoksen sekaan lisätään kerätty tai valutettu puhdistamaton raakapihka halutussa suhteessa (tavallisesti painosuhteessa 1:1). Seos pidetään suljetussa astiassa huoneen lämmössä useita päiviä, tarvittaessa 2-6 viikkoa, jonka jälkeen se puhdistetaan roskista ym suodattamalla ja siivilöimällä. Seosta sekoitetaan joko jatkuvasti tai aika 10 ajoin (esim. kerran päivässä) liukenemisen edistämiseksi. Usean päivän tai viikon aikana saadaan juokseva liuos, jossa pihkapitoisuus painoyksikkönä nousee ad 60 %:ksi (pihkapitoisuus voidaan mitata punnitsemalla alkoholiliuoksen paino ennen alkoholin haihduttamista ja sen jälkeen). Liuoksen pihkapitoisuus on painomittauksien erotus suhteutettuna mittauksessa käytettyyn liuoksen tilavuuteen tai painoon.denatured concentrated alcohol or the like) and to the solution is added the crude or collected crude resin collected or drained in the desired ratio (usually 1: 1 by weight). The mixture is kept in a sealed container at room temperature for several days, if necessary for 2-6 weeks, after which it is cleaned of debris etc. by filtration and straining. The mixture is stirred either continuously or at 10 times (e.g. once daily) to promote dissolution. Over several days or weeks, a fluid solution is obtained which raises the pitch to 60% by weight (the pitch can be measured by weighing the weight of the alcohol solution before and after evaporation of the alcohol). The resin content of the solution is the difference between the weight measurements relative to the volume or weight of the solution used in the measurement.
15 Keksinnön ajatuksen mukaisesti alkoholiin liukenevat pihkan biologisesti ja antimikrobisesti vaikuttavat komponentit, diterpeenit ja lignaanit, samoina fysiologisina suhteellisina pitoisuuksina, kuin mitä on puhtaassa pihkassa. Puhdistetusta pihkasta, keksinnön mukaisesta pihkaliuoksesta, sekä siitä valmistetuista rasvaseoksista, liukenee pieniä määriä pihkan biologisesti vaikuttavia yhdisteitä (diterpeenejä ja lignaaneja) vesifaasiin. Tämä voidaan todeta kaasukromatografisella (Gas-Liquid-20 Chromatography/GLC) mittauksella (kuva 1). Ames'in testin mukaan liuoksella tai siitä valmistetulla salvalla ei ole todettavissa genotoksisuutta (kuva 2).According to the idea of the invention, the alcohol-soluble resin components of biological and antimicrobial activity, diterpenes and lignans, at the same physiological relative concentrations as pure resin. From the purified resin, the resin solution according to the invention, and the fat blends made from it, small amounts of the biologically active compounds (diterpenes and lignans) of the resin dissolve in the aqueous phase. This can be detected by gas chromatography (Gas-Liquid-20 Chromatography / GLC) measurement (Figure 1). According to the Ames test, the solution or the ointment made from it does not show genotoxicity (Figure 2).
Keksinnön mukainen liuos on juoksevaa huoneen lämpötilassa. Liuos voidaan kaataa, sitä voidaan sivellä, suihkuttaa tai valuttaa halutulle pinnalle tai astiaan.The solution of the invention is fluid at room temperature. The solution can be poured, brushed, sprayed or drained onto a desired surface or container.
Keksinnön mukainen liuos on seos, joka voidaan sekoittaa (liuottaa) muuhun toiseen ainesosaan ^ 25 (esim. salva, rasva, neste, jne.) jolloin kyseiseen toiseen aineeseen saadaan kaikki pihkan o komponentit sekoittumaan luonnollisessa suhteessa ja pitoisuuksina, jotka ovat sekoitussuhteiden 5 avulla ennalta tarkasti määriteltävissä.The solution according to the invention is a mixture which can be mixed (dissolved) with another other ingredient (eg ointment, grease, liquid, etc.) whereby all the constituents of the resin o are mixed in said second substance in natural proportions and at concentrations pre-mixed. precisely defined.
x cc ^ Pihkanliuos voidaan valmistaa edellä kuvatulla tavalla myös muita liuottimia käyttäen (asetoni, ou eetteri, kloroformi ym.).The resin solution can also be prepared as described above using other solvents (acetone, ether, chloroform, etc.).
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Kirjallisuutta: 1. Sipponen A ym. Beneficial effect of resin salve in treatment of severe pressure ulcers: a prospective, randomized and controlled multicentre trial. Br J Dermatol 2008;158:1055-62References: 1. Sipponen A et al., A Beneficial Effect of Resin Salve in the Treatment of Severe Pressure Ulcers: A Prospective, Randomized and Controlled Multicenter Trial. Br J Dermatol 2008; 158: 1055-62
2. Rautio M ym. Antimicrobial effects of home-made resin salve from Norway spruce. APM1S2. Antimicrobial effects of home-made resin salve from Norway spruce by Rautio M et al. APM1S
5 2007;115:335-40 δ5 2007; 115: 335-40 δ
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Claims (3)
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FI20080325A FI122095B (en) | 2008-04-30 | 2008-04-30 | Resin solution used in the preparation of ointment |
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FI20080325A FI122095B (en) | 2008-04-30 | 2008-04-30 | Resin solution used in the preparation of ointment |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016116667A1 (en) | 2015-01-20 | 2016-07-28 | Repolar Pharmaceuticals Oy | Coniferous resin for treating and preventing sterile inflammation |
WO2021219939A1 (en) * | 2020-04-28 | 2021-11-04 | Nordic Biotech Group Oy | Salve composition, method of manufacture and use of the composition |
-
2008
- 2008-04-30 FI FI20080325A patent/FI122095B/en active IP Right Grant
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016116667A1 (en) | 2015-01-20 | 2016-07-28 | Repolar Pharmaceuticals Oy | Coniferous resin for treating and preventing sterile inflammation |
WO2021219939A1 (en) * | 2020-04-28 | 2021-11-04 | Nordic Biotech Group Oy | Salve composition, method of manufacture and use of the composition |
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Publication number | Publication date |
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FI20080325A (en) | 2009-10-31 |
FI20080325A0 (en) | 2008-04-30 |
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