FI112824B - Menetelmä uloshengitetyn kaasun analysoimiseksi - Google Patents
Menetelmä uloshengitetyn kaasun analysoimiseksi Download PDFInfo
- Publication number
- FI112824B FI112824B FI990771A FI990771A FI112824B FI 112824 B FI112824 B FI 112824B FI 990771 A FI990771 A FI 990771A FI 990771 A FI990771 A FI 990771A FI 112824 B FI112824 B FI 112824B
- Authority
- FI
- Finland
- Prior art keywords
- ethanol
- methanol
- gas
- analysis
- exhaled
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 28
- 238000004458 analytical method Methods 0.000 title description 33
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 159
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 120
- 239000007789 gas Substances 0.000 claims description 58
- 238000001228 spectrum Methods 0.000 claims description 41
- 238000012360 testing method Methods 0.000 claims description 25
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 25
- 239000008280 blood Substances 0.000 claims description 21
- 210000004369 blood Anatomy 0.000 claims description 21
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 13
- 238000001514 detection method Methods 0.000 claims description 12
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 claims description 10
- 238000007664 blowing Methods 0.000 claims description 9
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 6
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 6
- 230000005855 radiation Effects 0.000 claims description 6
- 238000012545 processing Methods 0.000 claims description 4
- 238000005033 Fourier transform infrared spectroscopy Methods 0.000 claims 1
- 238000001704 evaporation Methods 0.000 claims 1
- 125000000468 ketone group Chemical group 0.000 claims 1
- 238000005259 measurement Methods 0.000 description 24
- 239000012071 phase Substances 0.000 description 16
- 238000010521 absorption reaction Methods 0.000 description 14
- 239000000203 mixture Substances 0.000 description 14
- 238000002474 experimental method Methods 0.000 description 11
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 10
- 238000002835 absorbance Methods 0.000 description 10
- 230000000875 corresponding effect Effects 0.000 description 9
- 239000000126 substance Substances 0.000 description 9
- 241000282414 Homo sapiens Species 0.000 description 8
- 239000007788 liquid Substances 0.000 description 8
- 230000029058 respiratory gaseous exchange Effects 0.000 description 8
- 230000003595 spectral effect Effects 0.000 description 8
- 150000001298 alcohols Chemical class 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 230000000241 respiratory effect Effects 0.000 description 7
- 150000001875 compounds Chemical class 0.000 description 6
- 238000004611 spectroscopical analysis Methods 0.000 description 6
- 208000005374 Poisoning Diseases 0.000 description 5
- 229910002092 carbon dioxide Inorganic materials 0.000 description 5
- 230000006870 function Effects 0.000 description 5
- 238000011545 laboratory measurement Methods 0.000 description 5
- 231100000572 poisoning Toxicity 0.000 description 5
- 230000000607 poisoning effect Effects 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 238000005192 partition Methods 0.000 description 4
- 238000004445 quantitative analysis Methods 0.000 description 4
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- 241000282412 Homo Species 0.000 description 3
- 239000012491 analyte Substances 0.000 description 3
- 235000013405 beer Nutrition 0.000 description 3
- 230000005587 bubbling Effects 0.000 description 3
- 239000001569 carbon dioxide Substances 0.000 description 3
- 230000035622 drinking Effects 0.000 description 3
- ZYBWTEQKHIADDQ-UHFFFAOYSA-N ethanol;methanol Chemical compound OC.CCO ZYBWTEQKHIADDQ-UHFFFAOYSA-N 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 239000011159 matrix material Substances 0.000 description 3
- 238000012544 monitoring process Methods 0.000 description 3
- 229920006395 saturated elastomer Polymers 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 229940035674 anesthetics Drugs 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000002596 correlated effect Effects 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 238000002405 diagnostic procedure Methods 0.000 description 2
- 229910001873 dinitrogen Inorganic materials 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000007792 gaseous phase Substances 0.000 description 2
- 239000003193 general anesthetic agent Substances 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- 239000007791 liquid phase Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000000691 measurement method Methods 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 229940007392 tylan Drugs 0.000 description 2
- WBPYTXDJUQJLPQ-VMXQISHHSA-N tylosin Chemical compound O([C@@H]1[C@@H](C)O[C@H]([C@@H]([C@H]1N(C)C)O)O[C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CC=O)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@H]1C[C@@](C)(O)[C@@H](O)[C@H](C)O1 WBPYTXDJUQJLPQ-VMXQISHHSA-N 0.000 description 2
- 235000019375 tylosin Nutrition 0.000 description 2
- 208000007848 Alcoholism Diseases 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 238000001157 Fourier transform infrared spectrum Methods 0.000 description 1
- 206010021133 Hypoventilation Diseases 0.000 description 1
- 238000004566 IR spectroscopy Methods 0.000 description 1
- 208000021251 Methanol poisoning Diseases 0.000 description 1
- 208000003443 Unconsciousness Diseases 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 231100000570 acute poisoning Toxicity 0.000 description 1
- 201000007930 alcohol dependence Diseases 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 229910001632 barium fluoride Inorganic materials 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000001601 blood-air barrier Anatomy 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000001273 butane Substances 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 239000003398 denaturant Substances 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- YUKYVUHULHUJSC-UHFFFAOYSA-N ethanol;methanol Chemical compound OC.OC.CCO YUKYVUHULHUJSC-UHFFFAOYSA-N 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 208000000122 hyperventilation Diseases 0.000 description 1
- 230000000870 hyperventilation Effects 0.000 description 1
- 239000004434 industrial solvent Substances 0.000 description 1
- 238000002329 infrared spectrum Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 238000011005 laboratory method Methods 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 238000013178 mathematical model Methods 0.000 description 1
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 1
- OFBQJSOFQDEBGM-UHFFFAOYSA-N n-pentane Natural products CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 210000004224 pleura Anatomy 0.000 description 1
- 210000003456 pulmonary alveoli Anatomy 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 238000013139 quantization Methods 0.000 description 1
- 239000012088 reference solution Substances 0.000 description 1
- 210000001533 respiratory mucosa Anatomy 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000012883 sequential measurement Methods 0.000 description 1
- HBMJWWWQQXIZIP-UHFFFAOYSA-N silicon carbide Chemical compound [Si+]#[C-] HBMJWWWQQXIZIP-UHFFFAOYSA-N 0.000 description 1
- 229910010271 silicon carbide Inorganic materials 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000002627 tracheal intubation Methods 0.000 description 1
- 239000003039 volatile agent Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N21/3504—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing gases, e.g. multi-gas analysis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/28—Investigating the spectrum
- G01J3/45—Interferometric spectrometry
- G01J3/453—Interferometric spectrometry by correlation of the amplitudes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/28—Investigating the spectrum
- G01J2003/2866—Markers; Calibrating of scan
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N2021/3595—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using FTIR
Landscapes
- Physics & Mathematics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI990771A FI112824B (fi) | 1999-04-08 | 1999-04-08 | Menetelmä uloshengitetyn kaasun analysoimiseksi |
| EP00660060A EP1043581B1 (de) | 1999-04-08 | 2000-03-29 | Verfahren zur Analyse von ausgeatmetem Gas |
| DE60028114T DE60028114T2 (de) | 1999-04-08 | 2000-03-29 | Verfahren zur Analyse von ausgeatmetem Gas |
| US09/544,147 US6555821B1 (en) | 1999-04-08 | 2000-04-06 | Method for analysis of expired gas |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI990771 | 1999-04-08 | ||
| FI990771A FI112824B (fi) | 1999-04-08 | 1999-04-08 | Menetelmä uloshengitetyn kaasun analysoimiseksi |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI990771A0 FI990771A0 (fi) | 1999-04-08 |
| FI990771A FI990771A (fi) | 2000-10-09 |
| FI112824B true FI112824B (fi) | 2004-01-15 |
Family
ID=8554374
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI990771A FI112824B (fi) | 1999-04-08 | 1999-04-08 | Menetelmä uloshengitetyn kaasun analysoimiseksi |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US6555821B1 (de) |
| EP (1) | EP1043581B1 (de) |
| DE (1) | DE60028114T2 (de) |
| FI (1) | FI112824B (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080053193A1 (en) * | 2003-04-28 | 2008-03-06 | Ahmad Lubna M | Thermoelectric sensor for analytes in a gas and related method |
| EP1627218A2 (de) * | 2003-04-28 | 2006-02-22 | Arizona Board of Regents, acting for and on behalf of, Arizona State University | Thermoelektrischer biosensor für analyten in einem gas |
| US8088333B2 (en) * | 2003-04-28 | 2012-01-03 | Invoy Technology, LLC | Thermoelectric sensor for analytes in a gas |
| US8722417B2 (en) | 2003-04-28 | 2014-05-13 | Invoy Technologies, L.L.C. | Thermoelectric sensor for analytes in a fluid and related method |
| US20080053194A1 (en) * | 2003-04-28 | 2008-03-06 | Ahmad Lubna M | Thermoelectric sensor for analytes in a gas and related method |
| US20110178420A1 (en) * | 2010-01-18 | 2011-07-21 | Trent Ridder | Methods and apparatuses for improving breath alcohol testing |
| WO2006060214A2 (en) * | 2004-11-18 | 2006-06-08 | The Regents Of The University Of California | Apparatus and methods for manipulation and optimization of biological systems |
| GB0717433D0 (en) * | 2007-09-07 | 2007-10-17 | Bedfont Scient Ltd | Apparatus and method |
| WO2010120891A2 (en) * | 2009-04-17 | 2010-10-21 | Linshom L.P. | System and method for monitoring breathing |
| US8911380B1 (en) | 2009-04-17 | 2014-12-16 | Linshom, L.P. | Respiration monitoring system and method |
| US8844337B2 (en) * | 2011-04-29 | 2014-09-30 | Theodosios Kountotsis | Breath actuation of electronic and non-electronic devices for preventing unauthorized access |
| US11624703B2 (en) | 2017-08-02 | 2023-04-11 | Vox Biomedical Llc | Virus sensing in exhaled breath by infrared spectroscopy |
| US10969333B2 (en) | 2017-08-02 | 2021-04-06 | Vox Biomedical Llc | Sensing cannabis and opioids in exhaled breath by infrared spectroscopy |
| US11300503B2 (en) * | 2017-08-30 | 2022-04-12 | Mls Acq, Inc. | Carbon ladder calibration |
| US20210151131A1 (en) * | 2019-11-19 | 2021-05-20 | Dylan WILKS | Multi-analyte concentration estimation for fixed-wavelength spectroscopy |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1986000712A1 (en) * | 1984-07-17 | 1986-01-30 | Werner Karl Adrian | Breath alcohol storage container and method of using same |
| US4801805A (en) * | 1987-08-19 | 1989-01-31 | Ford Motor Company | Method of measuring multicomponent constituency of gas emission flow |
| EP0522674B1 (de) * | 1991-07-12 | 1998-11-11 | Mark R. Robinson | Oximeter zur zuverlässigen klinischen Bestimmung der Blutsauerstoffsättigung in einem Fötus |
| WO1993009413A2 (en) * | 1991-10-28 | 1993-05-13 | Critikon, Inc. | Filter selection for shutterless optically stabilized capnograph |
| US5313406A (en) * | 1992-06-10 | 1994-05-17 | Temet Instruments Oy | Procedures for analyzing multicomponent FT-IR spectra for unknown mixtures of gases |
| US5355880A (en) * | 1992-07-06 | 1994-10-18 | Sandia Corporation | Reliable noninvasive measurement of blood gases |
| US5741707A (en) * | 1992-12-31 | 1998-04-21 | Schlumberger Technology Corporation | Method for quantitative analysis of earth samples |
| US5838008A (en) * | 1996-12-18 | 1998-11-17 | University Of Wollongong | Method and apparatus for measuring gas concentrations and isotope ratios in gases |
-
1999
- 1999-04-08 FI FI990771A patent/FI112824B/fi not_active IP Right Cessation
-
2000
- 2000-03-29 DE DE60028114T patent/DE60028114T2/de not_active Expired - Lifetime
- 2000-03-29 EP EP00660060A patent/EP1043581B1/de not_active Expired - Lifetime
- 2000-04-06 US US09/544,147 patent/US6555821B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| FI990771A (fi) | 2000-10-09 |
| DE60028114T2 (de) | 2006-12-21 |
| DE60028114D1 (de) | 2006-06-29 |
| FI990771A0 (fi) | 1999-04-08 |
| EP1043581B1 (de) | 2006-05-24 |
| EP1043581A1 (de) | 2000-10-11 |
| US6555821B1 (en) | 2003-04-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |