FI102190B1 - Method for Preparation of New Forms of Colony Stimulating Factor-1 and DNA Sequences, Vectors, Expression Systems and Recombinant Cells Used Therein - Google Patents

Method for Preparation of New Forms of Colony Stimulating Factor-1 and DNA Sequences, Vectors, Expression Systems and Recombinant Cells Used Therein

Info

Publication number
FI102190B1
FI102190B1 FI883056A FI883056A FI102190B1 FI 102190 B1 FI102190 B1 FI 102190B1 FI 883056 A FI883056 A FI 883056A FI 883056 A FI883056 A FI 883056A FI 102190 B1 FI102190 B1 FI 102190B1
Authority
FI
Finland
Prior art keywords
dna sequences
stimulating factor
colony stimulating
vectors
preparation
Prior art date
Application number
FI883056A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI883056A (en
FI102190B (en
FI883056A0 (en
Inventor
Kirston Edward Koths
Robert Forgan Halenbeck
Ernest Seigo Kawasaki
Martha Ballie Ladner
Mazie Yee Coyne
Arsdell Janelle Nobel Van
George Arthur Martin
Original Assignee
Cetus Oncology Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cetus Oncology Corp filed Critical Cetus Oncology Corp
Publication of FI883056A publication Critical patent/FI883056A/en
Publication of FI883056A0 publication Critical patent/FI883056A0/en
Application granted granted Critical
Publication of FI102190B1 publication Critical patent/FI102190B1/en
Publication of FI102190B publication Critical patent/FI102190B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

A colony stimulating factor, CSF-1, is a lymphokine useful in regulating the immune system. CSF-1 is obtained in usable amounts by recombinant methods, including cloning and expression of the murine and human DNA sequences encoding this protein. Both "long" and "short" forms of this protein and muteins corresponding to the cDNA-encoded forms are disclosed.
FI883056A 1986-10-24 1988-06-23 Method for Preparation of New Forms of Colony Stimulating Factor R-1 and DNA Sequences, Vectors, Expression Systems and Recombinant Cells Used Therein FI102190B (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US92306786A 1986-10-24 1986-10-24
US92306786 1986-10-24
US3965487A 1987-04-16 1987-04-16
US3965787A 1987-04-16 1987-04-16
US3965787 1987-04-16
US3965487 1987-04-16
US8702679 1987-10-16
PCT/US1987/002679 WO1988003173A2 (en) 1986-10-24 1987-10-16 New forms of colony stimulating factor-1

Publications (4)

Publication Number Publication Date
FI883056A FI883056A (en) 1988-06-23
FI883056A0 FI883056A0 (en) 1988-06-23
FI102190B1 true FI102190B1 (en) 1998-10-30
FI102190B FI102190B (en) 1998-10-30

Family

ID=27365583

Family Applications (1)

Application Number Title Priority Date Filing Date
FI883056A FI102190B (en) 1986-10-24 1988-06-23 Method for Preparation of New Forms of Colony Stimulating Factor R-1 and DNA Sequences, Vectors, Expression Systems and Recombinant Cells Used Therein

Country Status (12)

Country Link
EP (1) EP0272779B1 (en)
JP (1) JP2644794B2 (en)
AT (1) ATE105869T1 (en)
AU (2) AU8007087A (en)
CA (1) CA1339032C (en)
DE (1) DE3789859T2 (en)
DK (1) DK174237B1 (en)
ES (1) ES2052580T3 (en)
FI (1) FI102190B (en)
HU (1) HU215241B (en)
NO (1) NO301775B1 (en)
WO (1) WO1988003173A2 (en)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5837229A (en) * 1985-02-05 1998-11-17 Chiron Corporation Uses of recombinant colony stimulating factor-1
US5573930A (en) 1985-02-05 1996-11-12 Cetus Oncology Corporation DNA encoding various forms of colony stimulating factor-1
US5104650A (en) * 1985-02-05 1992-04-14 Cetus Corporation Uses of recombinant colony stimulating factor-1
US5556620A (en) * 1985-02-05 1996-09-17 Cetus Oncology Corporation Use of recombinant colony stimulating factor-1 to enhance wound healing
US6156300A (en) * 1985-02-05 2000-12-05 Chiron Corporation Point mutants of N∇2 CSF-1 and carboxy truncated fragments thereof
US5422105A (en) * 1985-02-05 1995-06-06 Cetus Oncology Corporation Use of recombinant colony stimulating factor 1
US6103224A (en) * 1985-02-05 2000-08-15 Chiron Corporation N∇2 CSF-1 (short form) and carboxy truncated fragments thereof
AU595864B2 (en) * 1986-03-14 1990-04-12 Otsuka Pharmaceutical Co., Ltd. Il-1 alpha derivatives and drugs
EP0307402B1 (en) * 1986-05-06 1993-08-11 Genetics Institute, Inc. Production of m-csf
JP2583770B2 (en) * 1986-09-17 1997-02-19 大塚製薬株式会社 gene
US5650297A (en) * 1986-09-17 1997-07-22 Otsuka Pharmaceutical Co., Ltd. DNA encoding human colony-stimulating factors
JP2583829B2 (en) * 1986-09-17 1997-02-19 大塚製薬株式会社 Human M-CSF
AU606099B2 (en) * 1986-12-07 1991-01-31 Japan Science And Technology Corporation Colony-stimulating factor and method for preparation thereof
CA1339757C (en) * 1987-04-16 1998-03-17 Robert F. Halenbeck Production of purified biologically active, bacterially produced recombinant human csf-1
US4929700A (en) * 1987-04-16 1990-05-29 Cetus Corporation Production of purified, biologically active, bacterially produced recombinant human CSF-1
CA1317244C (en) * 1987-07-24 1993-05-04 Ernest Seigo Kawasaki Production of biologically active forms of csf using a baculovirus (acnpv)-insect cell expression system
DK54589A (en) * 1988-02-08 1989-08-09 Otsuka Pharma Co Ltd HUMAN COLONIST MULATING FACTORS
JPH0610137B2 (en) * 1988-02-29 1994-02-09 新技術事業団 Human hematopoietic disease therapeutic agent containing human monocyte-macrophage colony stimulating factor as an active ingredient
US5171675A (en) * 1988-07-28 1992-12-15 Cerretti Douglas P Macrophage colony stimulating factor-γ
WO1990012877A1 (en) * 1989-04-19 1990-11-01 Cetus Corporation Multifunctional m-csf proteins and genes encoding therefor
DE69026440T2 (en) * 1989-07-27 1996-10-17 Denki Kagaku Kogyo Kk M-CSF coding gene and associated recombinant systems
EP0452505A4 (en) * 1989-11-07 1991-10-30 Otsuka Pharmaceutical Co., Ltd. M-csf derivative, expression vector of said derivative, product of transformation by said vector, and production of them
US5714140A (en) * 1989-12-13 1998-02-03 Otsuka Pharmaceutical Co., Ltd. Method for inhibiting the production of bioactive IL-1 by administering M-CSF
DE4014750A1 (en) * 1990-05-08 1991-11-14 Boehringer Mannheim Gmbh MUTEINE OF THE GRANULOCYTE-STIMULATING FACTOR (G-CSF)
AU639091B2 (en) * 1991-04-24 1993-07-15 Otsuka Pharmaceutical Co., Ltd. M-csf derivatives, expression vectors for said derivatives, transformants carrying said vectors and production of these
WO1993025687A1 (en) 1992-06-09 1993-12-23 Chiron Corporation Crystallization of m-csf
AU6125294A (en) * 1993-01-13 1994-08-15 Genetics Institute Inc. Process for producing m-csf 223
GB2355791B (en) 1999-10-28 2004-10-20 Molecular Light Tech Res Ltd Detection of mRNA expression using chemiluminescent labelled probes
KR100371264B1 (en) * 2000-01-25 2003-02-05 양문식 Recombinant vector harboring murine GM-CSF and recombinant Aspergilus niger expressing the vector
ES2591107T3 (en) 2009-10-06 2016-11-24 Regeneron Pharmaceuticals, Inc. Genetically modified mice and graft
RU2730643C2 (en) * 2011-02-15 2020-08-24 Ридженерон Фармасьютикалз, Инк. Humanised m-csf mice
KR102594390B1 (en) 2012-09-07 2023-10-27 예일 유니버시티 Genetically modified non-human animals and methods of use thereof
CN104918483B (en) 2012-11-05 2018-05-11 再生元制药公司 Generation and the method using genetically modified non-human animal
ES2964597T3 (en) 2014-05-19 2024-04-08 Regeneron Pharma Genetically modified mice that express human EPO
CN107896479B (en) 2015-04-13 2021-07-13 再生元制药公司 Humanized SIRP alpha-IL 15 knock-in mice and methods of use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2561255B2 (en) * 1985-02-05 1996-12-04 シタス コ−ポレイシヨン Recombinant colony-stimulating factor ▲ below- ▼ 1
JP2583770B2 (en) * 1986-09-17 1997-02-19 大塚製薬株式会社 gene

Also Published As

Publication number Publication date
AU8149491A (en) 1991-10-31
DK350188D0 (en) 1988-06-24
WO1988003173A2 (en) 1988-05-05
EP0272779A2 (en) 1988-06-29
EP0272779A3 (en) 1988-08-03
DE3789859D1 (en) 1994-06-23
ES2052580T3 (en) 1994-07-16
JPH01501283A (en) 1989-05-11
FI883056A (en) 1988-06-23
HUT47635A (en) 1989-03-28
FI102190B (en) 1998-10-30
NO301775B1 (en) 1997-12-08
EP0272779B1 (en) 1994-05-18
ATE105869T1 (en) 1994-06-15
DE3789859T2 (en) 1994-09-15
AU646277B2 (en) 1994-02-17
HU215241B (en) 1998-11-30
JP2644794B2 (en) 1997-08-25
DK174237B1 (en) 2002-10-07
DK350188A (en) 1988-08-19
FI883056A0 (en) 1988-06-23
CA1339032C (en) 1997-04-01
NO882772D0 (en) 1988-06-22
NO882772L (en) 1988-08-22
WO1988003173A3 (en) 1988-07-28
AU8007087A (en) 1988-04-28

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FD Application lapsed
MM Patent lapsed

Owner name: CETUS ONCOLOGY CORPORATION