FI101880B1 - Process for the conversion of R (-) 2- (3-benzoylphenyl) propionic acid to the S (+) isomer - Google Patents

Process for the conversion of R (-) 2- (3-benzoylphenyl) propionic acid to the S (+) isomer

Info

Publication number
FI101880B1
FI101880B1 FI930751A FI930751A FI101880B1 FI 101880 B1 FI101880 B1 FI 101880B1 FI 930751 A FI930751 A FI 930751A FI 930751 A FI930751 A FI 930751A FI 101880 B1 FI101880 B1 FI 101880B1
Authority
FI
Finland
Prior art keywords
isomer
benzoylphenyl
conversion
propionic acid
propionic
Prior art date
Application number
FI930751A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI101880B (en
FI930751A (en
FI930751A0 (en
Inventor
Claude Bertrand
Elie Fouque
Fur Isidore Le
Jean-Paul Richard
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of FI930751A publication Critical patent/FI930751A/en
Publication of FI930751A0 publication Critical patent/FI930751A0/en
Application granted granted Critical
Publication of FI101880B publication Critical patent/FI101880B/en
Publication of FI101880B1 publication Critical patent/FI101880B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/487—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Detergent Compositions (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Process for transforming (benzoyl-3 phenyl)-2 propionic-R(-) acid into an S(+) isomer through the action of a base either in situ during the splitting of racemic ketoprofen or on the crystallization mother liquor of a (benzoyl-3 phenyl)-2 propionic-S(+) acid salt.
FI930751A 1990-08-20 1993-02-19 Process for the conversion of R (-) 2- (3-benzoylphenyl) propionic acid to the S (+) isomer FI101880B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR9010460A FR2665897B1 (en) 1990-08-20 1990-08-20 PROCESS FOR THE CONVERSION OF ACID (BENZOYL-3 PHENYL) -2 PROPIONIC-R (-) TO THE S (+) ISOMER.
FR9010460 1990-08-20
FR9100670 1991-01-22
PCT/FR1991/000670 WO1992003404A1 (en) 1990-08-20 1991-08-19 Process for transforming (benzoyl-3 phenyl)-2 propionic acid into an s(+) isomer

Publications (4)

Publication Number Publication Date
FI930751A FI930751A (en) 1993-02-19
FI930751A0 FI930751A0 (en) 1993-02-19
FI101880B FI101880B (en) 1998-09-15
FI101880B1 true FI101880B1 (en) 1998-09-15

Family

ID=9399732

Family Applications (1)

Application Number Title Priority Date Filing Date
FI930751A FI101880B1 (en) 1990-08-20 1993-02-19 Process for the conversion of R (-) 2- (3-benzoylphenyl) propionic acid to the S (+) isomer

Country Status (19)

Country Link
EP (1) EP0544740B1 (en)
JP (1) JP3100059B2 (en)
AT (1) ATE108172T1 (en)
AU (1) AU8445691A (en)
CA (1) CA2089558A1 (en)
CS (1) CS256791A3 (en)
DE (1) DE69102767T2 (en)
DK (1) DK0544740T3 (en)
ES (1) ES2056657T3 (en)
FI (1) FI101880B1 (en)
FR (1) FR2665897B1 (en)
HU (1) HUT63373A (en)
IE (1) IE64689B1 (en)
NO (1) NO179001C (en)
NZ (1) NZ239435A (en)
PL (1) PL297972A1 (en)
PT (1) PT98726B (en)
WO (1) WO1992003404A1 (en)
ZA (1) ZA916496B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5162576A (en) * 1991-04-15 1992-11-10 Ethyl Corporation Resolution of ketoprofen
WO1996023759A1 (en) * 1995-01-31 1996-08-08 Nagase & Company, Ltd. Method of racemizing optically active carboxylic acids
US6459878B1 (en) 1999-09-30 2002-10-01 Canon Kabushiki Kaisha Heating assembly, image-forming apparatus, and process for producing silicone rubber sponge and roller
CN102010327B (en) * 2009-09-07 2013-04-10 浙江九洲药业股份有限公司 Splitting method of (+/-)-2-(3-benzoyl)-phenylpropionic acid

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1201726A (en) * 1959-06-20 1960-01-05 Process for obtaining flavonic derivatives from the leaves of certain plants
IT1175941B (en) * 1984-02-16 1987-08-12 Stabil Bioterapico Farmachim MONO, BI AND TRI-SUBSTITUTED ALUMINUM SALTS OF ARYL-ALCANOIC ACIDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US4831147A (en) * 1988-07-05 1989-05-16 The Dow Chemical Company Resolution of enantiomers of herbicidal 2-(4-aryloxyphenoxy) propionates by chiral two-phase extraction
DE3824353A1 (en) * 1988-07-19 1990-01-25 Paz Arzneimittelentwicklung METHOD FOR SEPARATING MIXED ENANTIOMER ARYLPROPIONIC ACIDS

Also Published As

Publication number Publication date
CS256791A3 (en) 1992-03-18
NZ239435A (en) 1993-04-28
CA2089558A1 (en) 1992-02-21
DE69102767D1 (en) 1994-08-11
ZA916496B (en) 1992-05-27
PT98726A (en) 1992-07-31
PL297972A1 (en) 1993-11-02
FI101880B (en) 1998-09-15
HU9300469D0 (en) 1993-05-28
JP3100059B2 (en) 2000-10-16
NO179001B (en) 1996-04-09
EP0544740B1 (en) 1994-07-06
PT98726B (en) 1999-01-29
ES2056657T3 (en) 1994-10-01
NO930546L (en) 1993-02-16
AU8445691A (en) 1992-03-17
FR2665897B1 (en) 1994-03-18
DE69102767T2 (en) 1994-10-27
NO179001C (en) 1996-07-17
EP0544740A1 (en) 1993-06-09
FI930751A (en) 1993-02-19
WO1992003404A1 (en) 1992-03-05
HUT63373A (en) 1993-08-30
FR2665897A1 (en) 1992-02-21
FI930751A0 (en) 1993-02-19
NO930546D0 (en) 1993-02-16
IE912917A1 (en) 1992-02-26
JPH06501683A (en) 1994-02-24
DK0544740T3 (en) 1994-08-22
IE64689B1 (en) 1995-08-23
ATE108172T1 (en) 1994-07-15

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Legal Events

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MA Patent expired