ES8802015A1 - Substituted alpha -amino acids, their preparation and pharmaceutical compositions containing them - Google Patents

Substituted alpha -amino acids, their preparation and pharmaceutical compositions containing them

Info

Publication number
ES8802015A1
ES8802015A1 ES555559A ES555559A ES8802015A1 ES 8802015 A1 ES8802015 A1 ES 8802015A1 ES 555559 A ES555559 A ES 555559A ES 555559 A ES555559 A ES 555559A ES 8802015 A1 ES8802015 A1 ES 8802015A1
Authority
ES
Spain
Prior art keywords
amino acids
group
preparation
ester
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES555559A
Other languages
Spanish (es)
Other versions
ES555559A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848408059A external-priority patent/GB8408059D0/en
Priority claimed from GB848421091A external-priority patent/GB8421091D0/en
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES555559A0 publication Critical patent/ES555559A0/en
Publication of ES8802015A1 publication Critical patent/ES8802015A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Substituted alpha -amino acids useful for treating epilepsy, disorders associated with excess GH or LH secretion, schizophrenia, depression, CNS degenerative disorders and cerebral hypoxic conditions. The compounds are of formula < IMAGE > where R1 is H or an ester-forming group A is an optionally substituted amino group m and n are 1, 2 or 3 X is S, SO, SO2, O, NH, NR, CONH or CONR (where R is a hydrocarbyl group of at least 2 carbon atoms Y is a phosphorus or sulphur containing acid or ester moiety, a carboxylic acid or ester or a tetrazolyl group.
ES555559A 1984-03-29 1986-05-30 Substituted alpha -amino acids, their preparation and pharmaceutical compositions containing them Expired ES8802015A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848408059A GB8408059D0 (en) 1984-03-29 1984-03-29 Organic compounds
GB848421091A GB8421091D0 (en) 1984-08-20 1984-08-20 Organic compounds

Publications (2)

Publication Number Publication Date
ES555559A0 ES555559A0 (en) 1988-03-16
ES8802015A1 true ES8802015A1 (en) 1988-03-16

Family

ID=26287523

Family Applications (3)

Application Number Title Priority Date Filing Date
ES541689A Expired ES8704957A1 (en) 1984-03-29 1985-03-28 Substituted alpha -amino acids, their preparation and pharmaceutical compositions containing them
ES555560A Expired ES8706622A1 (en) 1984-03-29 1986-05-30 Substituted alpha -amino acids, their preparation and pharmaceutical compositions containing them
ES555559A Expired ES8802015A1 (en) 1984-03-29 1986-05-30 Substituted alpha -amino acids, their preparation and pharmaceutical compositions containing them

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES541689A Expired ES8704957A1 (en) 1984-03-29 1985-03-28 Substituted alpha -amino acids, their preparation and pharmaceutical compositions containing them
ES555560A Expired ES8706622A1 (en) 1984-03-29 1986-05-30 Substituted alpha -amino acids, their preparation and pharmaceutical compositions containing them

Country Status (16)

Country Link
AU (1) AU4042585A (en)
BE (1) BE902040A (en)
DE (1) DE3510858A1 (en)
DK (1) DK139185A (en)
ES (3) ES8704957A1 (en)
FI (1) FI851234L (en)
FR (1) FR2562076A1 (en)
GB (1) GB2156818B (en)
GR (1) GR850770B (en)
HU (1) HUT40447A (en)
IL (1) IL74734A0 (en)
IT (1) IT1199964B (en)
LU (1) LU85826A1 (en)
NL (1) NL8500847A (en)
PT (1) PT80178B (en)
SE (1) SE8501548L (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5217963A (en) * 1985-05-24 1993-06-08 Ciba-Geigy Corporation Certain phosphonic acid quinoline-2-carboxylic acids, esters or amides useful for treatment of disorders responsive to N-methyl D-aspartate receptor blockade
US4906621A (en) * 1985-05-24 1990-03-06 Ciba-Geigy Corporation Certain 2-carboxypiperidyl-alkylene phosphonic acids and esters thereof useful for the treatment of disorders responsive to N-methyl-D-aspartate receptor blockade
US4746653A (en) * 1986-02-28 1988-05-24 Ciba-Geigy Corporation Certain hetero phosphonic acid derivatives of 2-piperidine or 2-tetrahydropyridinecarboxylates and esters thereof which are useful for the treatment of disorders responsive to blockade of the NMDA receptor in mammals
US5175153A (en) * 1987-11-30 1992-12-29 Warner-Lambert Company Substituted alpha-amino acids having pharmaceutical activity
IT1216096B (en) * 1988-03-15 1990-02-22 Farmaceutica Italiana S P A S L_PIROGLUTAMIL_L_CISTEINA, DIPEPTIDE WITH HIGH ANTI-CATHATOGEN ACTIVITY AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN IT.
EP0436612A4 (en) * 1988-09-30 1992-05-20 Australian Commercial Research & Development Limited Amino acid transport proteins, amino acid analogues, assay apparatus, uses thereof for treatment and diagnosis of cancer
US5179085A (en) * 1989-03-15 1993-01-12 Warner-Lambert Company N-substituted α-amino acids and derivatives thereof having pharmaceutical activity
US5500419A (en) * 1989-09-19 1996-03-19 Merrell Dow Pharmaceuticals Inc. NMDA antagonists
JPH03236315A (en) * 1989-12-05 1991-10-22 Nippon Oil & Fats Co Ltd Antipsychotic agent
US5238958A (en) * 1990-02-26 1993-08-24 Warner-Lambert Company Substituted α-amino acids having selected acidic moieties for use as excitatory amino acid antagonists in pharmaceuticals
IT1249650B (en) * 1991-05-29 1995-03-09 Poli Ind Chimica Spa N- (5-TIOXO-L-PROLIL) -L-CISTEIN AND ITS DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE
IT1256178B (en) * 1992-11-30 1995-11-29 Lorenzo Ferrari COMPOUNDS WITH THERAPEUTIC ACTIVITIES USEFUL FOR THE TREATMENT OF DISEASES CONNECTED WITH A GLUTATION DEFICIENCY, PROCEDURE FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
DE4433555B4 (en) * 1994-09-07 2005-04-28 Guenther Oehme Water-soluble chiral and achiral phosphines, process for their preparation and their use
DE10045831A1 (en) * 2000-09-14 2002-04-04 Gruenenthal Gmbh Anticonvulsant, anxiolytic and especially analgesic medicaments, comprising new or known beta-thio-alpha-aminoacid compounds having strong affinity for gabapentin binding site
ES2252310T3 (en) 2000-09-14 2006-05-16 Grunenthal Gmbh BETA-THIOAMINOACID.
CA2458720A1 (en) * 2001-09-18 2003-03-27 Vasogen Ireland Limited Apoptosis-mimicking synthetic entities and use thereof in medical treatment
EP3427729A1 (en) 2017-07-13 2019-01-16 Paris Sciences et Lettres - Quartier Latin Probenecid for use in treating epileptic diseases, disorders or conditions
BR112020004444A2 (en) 2017-09-08 2020-09-15 F. Hoffmann-La Roche Ag sulfoxide-based reagent for mass spectrometry

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2104079B (en) * 1981-08-14 1985-08-21 London Polytech New aminoacid isomers, their production and their medicinal use

Also Published As

Publication number Publication date
PT80178A (en) 1985-04-01
ES8706622A1 (en) 1987-07-01
HUT40447A (en) 1986-12-28
GB2156818B (en) 1987-10-21
AU4042585A (en) 1985-10-03
IT8547877A1 (en) 1986-09-27
ES541689A0 (en) 1987-04-16
IT1199964B (en) 1989-01-05
GR850770B (en) 1985-07-23
FI851234A0 (en) 1985-03-27
IT8547877A0 (en) 1985-03-27
DK139185D0 (en) 1985-03-27
IL74734A0 (en) 1985-06-30
NL8500847A (en) 1985-10-16
GB2156818A (en) 1985-10-16
DE3510858A1 (en) 1985-10-10
PT80178B (en) 1987-03-20
BE902040A (en) 1985-09-30
DK139185A (en) 1985-09-30
ES555560A0 (en) 1987-07-01
GB8507794D0 (en) 1985-05-01
ES8704957A1 (en) 1987-04-16
FR2562076A1 (en) 1985-10-04
SE8501548D0 (en) 1985-03-28
LU85826A1 (en) 1985-12-12
ES555559A0 (en) 1988-03-16
SE8501548L (en) 1985-09-30
FI851234L (en) 1985-09-30

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