ES8801510A1 - Un procedimiento para preparar nuevos compuestos de 2-oxa-o -aza-pregnano - Google Patents

Un procedimiento para preparar nuevos compuestos de 2-oxa-o -aza-pregnano

Info

Publication number
ES8801510A1
ES8801510A1 ES557574A ES557574A ES8801510A1 ES 8801510 A1 ES8801510 A1 ES 8801510A1 ES 557574 A ES557574 A ES 557574A ES 557574 A ES557574 A ES 557574A ES 8801510 A1 ES8801510 A1 ES 8801510A1
Authority
ES
Spain
Prior art keywords
aza
oxa
image
group
pregnane compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557574A
Other languages
English (en)
Other versions
ES557574A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aska Pharmaceutical Co Ltd
Original Assignee
Teikoku Hormone Manufacturing Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP4373285A external-priority patent/JPS61204199A/ja
Priority claimed from JP60043731A external-priority patent/JPS61204198A/ja
Application filed by Teikoku Hormone Manufacturing Co Ltd filed Critical Teikoku Hormone Manufacturing Co Ltd
Publication of ES557574A0 publication Critical patent/ES557574A0/es
Publication of ES8801510A1 publication Critical patent/ES8801510A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/003—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by oxygen as hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/16—Benz[e]indenes; Hydrogenated benz[e]indenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE COMPUESTOS DE 2-OXAO -AZA-PREGNADO, DE FORMULA GENERAL (I). CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (II), EN LA QUE A REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALCANOILO INFERIOR; Z REPRESENTA UN ATOMO DE OXIGENO; Y X REPRESENTA UN ATOMO DE HALOGENO, CON UN DERIVADO REACTIVO DE UN ACIDO ALCANOILO INFERIOR, A UNA TEMPERATURA COMPRENDIDA ENTRE LA TEMPERATURA AMBIENTE Y LA TEMPERATURA DE REFLUJO DE LA MEZCLA DE REACCION, EN AUSENCIA DE DISOLVENTE O EN EL SENO DE UN DISOLVENTE INERTE. DE APLICACION EN LA PREPARACION DE FARMACOS UTILIZADOS EN LA PREVENCION, TERAPIA Y TRATAMIENTO DE ENFERMEDADES DEPENDIENTES DE ANDROGENOS, TALES COMO LA HIPERTROFIA PROSTATICA, EL CANCER DE PROSTATA, LA ALOPECIA, EL ACNE Y LA SEBORREA.
ES557574A 1985-03-07 1987-05-29 Un procedimiento para preparar nuevos compuestos de 2-oxa-o -aza-pregnano Expired ES8801510A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP4373285A JPS61204199A (ja) 1985-03-07 1985-03-07 ２−アザプレグナン化合物
JP60043731A JPS61204198A (ja) 1985-03-07 1985-03-07 ２−オキサプレグナン化合物

Publications (2)

Publication Number Publication Date
ES557574A0 ES557574A0 (es) 1988-01-16
ES8801510A1 true ES8801510A1 (es) 1988-01-16

Family

ID=26383560

Family Applications (4)

Application Number Title Priority Date Filing Date
ES552724A Expired ES8801669A1 (es) 1985-03-07 1986-03-06 Un procedimiento para preparar nuevos compuestos de 2-oxa-0 aza-pregnano.
ES557574A Expired ES8801510A1 (es) 1985-03-07 1987-05-29 Un procedimiento para preparar nuevos compuestos de 2-oxa-o -aza-pregnano
ES557573A Expired ES8801928A1 (es) 1985-03-07 1987-05-29 Un procedimiento para preparar nuevos compuestos de 2-oxa pregnano.
ES557572A Expired ES8801670A1 (es) 1985-03-07 1987-05-29 Un procedimiento para preparar nuevos compuestos de 2-oxa pregnano.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES552724A Expired ES8801669A1 (es) 1985-03-07 1986-03-06 Un procedimiento para preparar nuevos compuestos de 2-oxa-0 aza-pregnano.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES557573A Expired ES8801928A1 (es) 1985-03-07 1987-05-29 Un procedimiento para preparar nuevos compuestos de 2-oxa pregnano.
ES557572A Expired ES8801670A1 (es) 1985-03-07 1987-05-29 Un procedimiento para preparar nuevos compuestos de 2-oxa pregnano.

Country Status (8)

Country Link
US (2) US4785103A (es)
EP (1) EP0193871B1 (es)
AU (1) AU576945B2 (es)
CA (1) CA1255293A (es)
DE (1) DE3663668D1 (es)
ES (4) ES8801669A1 (es)
IN (1) IN162700B (es)
NZ (1) NZ215328A (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4785103A (en) * 1985-03-07 1988-11-15 Teikoku Hormone Mfg. Co., Ltd. 2-oxa- or -aza-pregnane compounds
US20020091155A1 (en) * 1995-06-22 2002-07-11 Btg Pharmaceutical Corp. Method for ameliorating muscle weakness/wasting in a patient infected with human immunodeficiency virus-type 1
US5872147A (en) * 1996-12-05 1999-02-16 Bio-Technology General Corp. Use of oxandrolone in the treatment of chronic obstructive pulmonary disease
AU2742102A (en) * 2000-12-14 2002-06-24 Ortho Mcneil Pharm Inc Steroid hormone products and methods for preparing them
MX2018013786A (es) 2016-05-11 2019-03-28 Aska Pharm Co Ltd POLIMORFO CRISTALINO DE ACETATO DE 15ß-HIDROXI-OSATERONA.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3179658A (en) * 1961-05-26 1965-04-20 Merck & Co Inc 2-oxa steroids and processes of preparing the same
US3093658A (en) * 1961-10-16 1963-06-11 Searle & Co 17alpha, 21-dihydroxy-2-oxapregnane-3, 11, 20-trione, esters thereof and intermediates thereto
US3080381A (en) * 1962-02-16 1963-03-05 Searle & Co Optionally 6-methylated and optionally 17-alkanoyloxygenated 2-oxapregnane-3, 20-diones, a-homo compounds corresponding, and 4, 5-dehydro and 4, 5; 6, 7-bisdehydro derivatives thereof
GB990656A (en) * 1962-04-23 1965-04-28 Searle & Co Compounds of the androstane series
US3280133A (en) * 1964-10-12 1966-10-18 Searle & Co (optionally alkylated)-2-aza-5alpha-androstan-17beta-ols and acyl derivatives thereof
US3526642A (en) * 1968-06-19 1970-09-01 Squibb & Sons Inc 2-oxa-5beta-cyanopregnane derivatives
GB8505862D0 (en) * 1985-03-07 1985-04-11 Erba Farmitalia Steroidic 5alpha-reductase inhibitors
US4785103A (en) * 1985-03-07 1988-11-15 Teikoku Hormone Mfg. Co., Ltd. 2-oxa- or -aza-pregnane compounds

Also Published As

Publication number Publication date
EP0193871A2 (en) 1986-09-10
ES552724A0 (es) 1988-02-16
ES557574A0 (es) 1988-01-16
IN162700B (es) 1988-07-02
AU576945B2 (en) 1988-09-08
EP0193871B1 (en) 1989-05-31
DE3663668D1 (de) 1989-07-06
ES557573A0 (es) 1988-03-01
US4914106A (en) 1990-04-03
CA1255293A (en) 1989-06-06
ES8801928A1 (es) 1988-03-01
NZ215328A (en) 1988-09-29
ES8801669A1 (es) 1988-02-16
US4785103A (en) 1988-11-15
ES557572A0 (es) 1988-02-16
EP0193871A3 (en) 1986-11-20
AU5424586A (en) 1986-09-11
ES8801670A1 (es) 1988-02-16

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20071126