ES8707741A1 - Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides. - Google Patents

Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides.

Info

Publication number
ES8707741A1
ES8707741A1 ES557145A ES557145A ES8707741A1 ES 8707741 A1 ES8707741 A1 ES 8707741A1 ES 557145 A ES557145 A ES 557145A ES 557145 A ES557145 A ES 557145A ES 8707741 A1 ES8707741 A1 ES 8707741A1
Authority
ES
Spain
Prior art keywords
polypeptides
growth factor
factor activity
nucleic acid
acid sequences
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557145A
Other languages
Spanish (es)
Other versions
ES557145A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oncogen LP
Original Assignee
Oncogen LP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncogen LP filed Critical Oncogen LP
Publication of ES557145A0 publication Critical patent/ES557145A0/en
Publication of ES8707741A1 publication Critical patent/ES8707741A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/14011—Baculoviridae
    • C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
    • C12N2710/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Polypeptides having growth factor activity and precursors thereof are synthesized using conventional or recombinant techniques. The framework structure of these peptides are shown in figures 1 and 2. The structure, particularly those involving six cysteines, provide loops analogous to mammalian growth factors. The peptides are disclosed as being useful as mitogens, additives in nutrient media, in assays for Epidermal Growth Factors (EGF) receptors, and in wound healing.
ES557145A 1984-10-30 1986-10-24 Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides. Expired ES8707741A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US66652084A 1984-10-30 1984-10-30

Publications (2)

Publication Number Publication Date
ES557145A0 ES557145A0 (en) 1987-08-16
ES8707741A1 true ES8707741A1 (en) 1987-08-16

Family

ID=24674411

Family Applications (7)

Application Number Title Priority Date Filing Date
ES548316A Expired ES8702925A1 (en) 1984-10-30 1985-10-29 Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides.
ES554629A Expired ES8802185A1 (en) 1984-10-30 1986-04-30 Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides.
ES554628A Expired ES8802061A1 (en) 1984-10-30 1986-04-30 Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides.
ES554630A Expired ES8802074A1 (en) 1984-10-30 1986-04-30 Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides.
ES557145A Expired ES8707741A1 (en) 1984-10-30 1986-10-24 Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides.
ES557710A Expired ES8801379A1 (en) 1984-10-30 1987-09-01 Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides.
ES557708A Expired ES8801378A1 (en) 1984-10-30 1987-09-01 Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides.

Family Applications Before (4)

Application Number Title Priority Date Filing Date
ES548316A Expired ES8702925A1 (en) 1984-10-30 1985-10-29 Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides.
ES554629A Expired ES8802185A1 (en) 1984-10-30 1986-04-30 Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides.
ES554628A Expired ES8802061A1 (en) 1984-10-30 1986-04-30 Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides.
ES554630A Expired ES8802074A1 (en) 1984-10-30 1986-04-30 Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES557710A Expired ES8801379A1 (en) 1984-10-30 1987-09-01 Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides.
ES557708A Expired ES8801378A1 (en) 1984-10-30 1987-09-01 Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides.

Country Status (12)

Country Link
EP (1) EP0199769A4 (en)
JP (1) JPS62501071A (en)
AU (2) AU600433B2 (en)
ES (7) ES8702925A1 (en)
FI (1) FI862734A (en)
GR (1) GR852610B (en)
IL (1) IL76866A0 (en)
NO (1) NO862613D0 (en)
NZ (1) NZ213984A (en)
PH (2) PH24603A (en)
PT (1) PT81408B (en)
WO (1) WO1986002650A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4863899A (en) * 1983-05-09 1989-09-05 Todaro George J Biologically active polypeptides
US5240912A (en) * 1983-05-09 1993-08-31 Todaro George J Transforming growth factor (TGF) peptides
KR950001993B1 (en) * 1985-12-18 1995-03-08 마이크로제네시스,인코포레이티드 Production of specific polypeptide in virally infected insect cells
FI891308A (en) * 1988-03-24 1989-09-25 Oncogen NYA POLYPEPTIDER MED TILLVAEXTFAKTORAKTIVITET OCH DESSA KODANDE NUCLEIN SYRASE SEQUENTOR.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE38892B1 (en) * 1973-03-28 1978-06-21 Ici Ltd Pharmaceutical compositions
US4366246A (en) * 1977-11-08 1982-12-28 Genentech, Inc. Method for microbial polypeptide expression
US4230691A (en) * 1978-05-23 1980-10-28 The Massachusetts General Hospital Nerve growth factor antibody and process
DK339781A (en) * 1980-08-05 1982-02-06 Searle & Co SYNTHETIC GEN
JPH064673B2 (en) * 1980-11-10 1994-01-19 ゲネンテツク・インコ−ポレ−テツド Hybrid type human leukocyte interferon
WO1985002198A1 (en) * 1983-11-01 1985-05-23 Amgen Microbial expression of type i transforming growth factor, polypeptide analogs thereof and hybrid egf/tgf polypeptides
GB8507666D0 (en) * 1985-03-25 1985-05-01 Wellcome Found Epidermal growth factor production

Also Published As

Publication number Publication date
AU600433B2 (en) 1990-08-16
ES8802185A1 (en) 1988-04-01
FI862734A0 (en) 1986-06-26
PH24603A (en) 1990-08-17
ES557708A0 (en) 1988-01-01
ES554630A0 (en) 1988-03-16
ES8802074A1 (en) 1988-03-16
IL76866A0 (en) 1986-02-28
NO862613L (en) 1986-06-27
AU4868785A (en) 1986-05-15
ES8801379A1 (en) 1988-01-01
EP0199769A4 (en) 1989-11-29
ES8702925A1 (en) 1987-01-16
JPS62501071A (en) 1987-04-30
ES554629A0 (en) 1988-04-01
FI862734A (en) 1986-06-26
NZ213984A (en) 1991-05-28
ES557145A0 (en) 1987-08-16
ES554628A0 (en) 1988-03-16
ES8802061A1 (en) 1988-03-16
ES557710A0 (en) 1988-01-01
ES8801378A1 (en) 1988-01-01
PH25794A (en) 1991-11-05
NO862613D0 (en) 1986-06-27
AU633377B2 (en) 1993-01-28
AU6655190A (en) 1991-01-24
ES548316A0 (en) 1987-01-16
PT81408B (en) 1987-11-11
EP0199769A1 (en) 1986-11-05
GR852610B (en) 1986-03-04
WO1986002650A1 (en) 1986-05-09
PT81408A (en) 1985-11-01

Similar Documents

Publication Publication Date Title
DE3583824D1 (en) PRECURSOR OF INSULIN, METHOD FOR THE PRODUCTION THEREOF AND METHOD FOR THE PRODUCTION OF HUMANINSULIN FROM SUCH PRECURSORS OF THE INSULIN.
IL87025A0 (en) Recombinant fibroblast growth factor analogs,their production,dna sequences encoding therefor and recombinant vectors and host cells containing said dna sequences
PT85349A (en) Method for the preparation of proteins with factor viii activity by microbial host cells expression vectors host cells antibodies
ES8600783A1 (en) Biosynthetically produced human nerve growth factor, process for producing it, compositions containing it, DNA sequence encoding it, vectors containing the sequence and host cells transformed thereby.
BG101408A (en) Analogs of keratinocyte growth factor
EP0559769A4 (en) Heparin binding mitogen with homology to epidermal growth factor (egf)
ATE272109T1 (en) RECOMBINANT COLLAGENASE TYPE I FROM CLOSTRIDIUM HISTOLYTICUM AND THE USE THEREOF FOR ISOLATING CELLS AND CELL COMPOUNDS
ES8802235A1 (en) Structure and properties of modified interferons.
AU6801487A (en) Method of producing a recombinant protein complex having human factor VIII:C activity
CA2076979A1 (en) Substantially pure transforming growth factor-.beta.-1-binding protein and nucleotide sequences expressing the binding protein
ES8504255A1 (en) Substantially pure porcine growth hormone, DNA sequences therefor, and expression vehicles and transfected microorganisms for the production of porcine growth hormone.
GB8626878D0 (en) Dna
ATE63750T1 (en) PEPTIDE, ITS PRODUCTION AND USE.
EP0236978A3 (en) Production of factor xiiia by gene technology
JPS6463395A (en) Oncostatin m and novel composition having antitumor activity
ES8801378A1 (en) Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides.
ATE109827T1 (en) METHOD FOR THE PRODUCTION OF PEPTIDES, RECOMBINANT PLASMID TO BE USED THEREFORE AND MYELOMA CELLS TRANSFORMED WITH SUCH PLASMID.
IE890950L (en) Novel polypeptides having growth factor activity and nucleic acid sequences enclding the polypeptides
ES2039390T3 (en) A PROCEDURE FOR PRODUCING A HUMAN B-CELL DIFFERENTIATION FACTOR.
ATE145939T1 (en) MITOGEN FOR SMOOTH MUSCLE AND ITS CODING DNA
BG44029A3 (en) Method for preparing of n- dimethyl morphinanic derivatives
EP0274560A3 (en) Human hematopoietic cell growth potentiating factor
GR3006212T3 (en)

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970303