ES8702925A1 - Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides. - Google Patents

Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides.

Info

Publication number
ES8702925A1
ES8702925A1 ES548316A ES548316A ES8702925A1 ES 8702925 A1 ES8702925 A1 ES 8702925A1 ES 548316 A ES548316 A ES 548316A ES 548316 A ES548316 A ES 548316A ES 8702925 A1 ES8702925 A1 ES 8702925A1
Authority
ES
Spain
Prior art keywords
polypeptides
growth factor
factor activity
nucleic acid
acid sequences
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES548316A
Other languages
Spanish (es)
Other versions
ES548316A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oncogen LP
Original Assignee
Oncogen LP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncogen LP filed Critical Oncogen LP
Publication of ES548316A0 publication Critical patent/ES548316A0/en
Publication of ES8702925A1 publication Critical patent/ES8702925A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/14011—Baculoviridae
    • C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
    • C12N2710/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Polypeptides having growth factor activity and precursors thereof are synthesized using conventional or recombinant techniques. The framework structure of these peptides are shown in figures 1 and 2. The structure, particularly those involving six cysteines, provide loops analogous to mammalian growth factors. The peptides are disclosed as being useful as mitogens, additives in nutrient media, in assays for Epidermal Growth Factors (EGF) receptors, and in wound healing.
ES548316A 1984-10-30 1985-10-29 Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides. Expired ES8702925A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US66652084A 1984-10-30 1984-10-30

Publications (2)

Publication Number Publication Date
ES548316A0 ES548316A0 (en) 1987-01-16
ES8702925A1 true ES8702925A1 (en) 1987-01-16

Family

ID=24674411

Family Applications (7)

Application Number Title Priority Date Filing Date
ES548316A Expired ES8702925A1 (en) 1984-10-30 1985-10-29 Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides.
ES554628A Expired ES8802061A1 (en) 1984-10-30 1986-04-30 Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides.
ES554629A Expired ES8802185A1 (en) 1984-10-30 1986-04-30 Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides.
ES554630A Expired ES8802074A1 (en) 1984-10-30 1986-04-30 Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides.
ES557145A Expired ES8707741A1 (en) 1984-10-30 1986-10-24 Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides.
ES557710A Expired ES8801379A1 (en) 1984-10-30 1987-09-01 Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides.
ES557708A Expired ES8801378A1 (en) 1984-10-30 1987-09-01 Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides.

Family Applications After (6)

Application Number Title Priority Date Filing Date
ES554628A Expired ES8802061A1 (en) 1984-10-30 1986-04-30 Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides.
ES554629A Expired ES8802185A1 (en) 1984-10-30 1986-04-30 Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides.
ES554630A Expired ES8802074A1 (en) 1984-10-30 1986-04-30 Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides.
ES557145A Expired ES8707741A1 (en) 1984-10-30 1986-10-24 Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides.
ES557710A Expired ES8801379A1 (en) 1984-10-30 1987-09-01 Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides.
ES557708A Expired ES8801378A1 (en) 1984-10-30 1987-09-01 Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides.

Country Status (12)

Country Link
EP (1) EP0199769A4 (en)
JP (1) JPS62501071A (en)
AU (2) AU600433B2 (en)
ES (7) ES8702925A1 (en)
FI (1) FI862734A0 (en)
GR (1) GR852610B (en)
IL (1) IL76866A0 (en)
NO (1) NO862613D0 (en)
NZ (1) NZ213984A (en)
PH (2) PH24603A (en)
PT (1) PT81408B (en)
WO (1) WO1986002650A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5240912A (en) * 1983-05-09 1993-08-31 Todaro George J Transforming growth factor (TGF) peptides
US4863899A (en) * 1983-05-09 1989-09-05 Todaro George J Biologically active polypeptides
EP0228036A3 (en) * 1985-12-18 1988-09-07 Microgenesys, Inc. Method for producing selected polypeptides in virally infected insect cells and polypeptides isolated therefrom
IL89673A0 (en) * 1988-03-24 1989-09-28 Oncogen Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE38892B1 (en) * 1973-03-28 1978-06-21 Ici Ltd Pharmaceutical compositions
US4366246A (en) * 1977-11-08 1982-12-28 Genentech, Inc. Method for microbial polypeptide expression
US4230691A (en) * 1978-05-23 1980-10-28 The Massachusetts General Hospital Nerve growth factor antibody and process
IE53166B1 (en) * 1980-08-05 1988-08-03 Searle & Co Synthetic urogastrone gene,corresponding plasmid recombinants,transformed cells,production thereof and urogastrone expression
JPH064673B2 (en) * 1980-11-10 1994-01-19 ゲネンテツク・インコ−ポレ−テツド Hybrid type human leukocyte interferon
WO1985002198A1 (en) * 1983-11-01 1985-05-23 Amgen Microbial expression of type i transforming growth factor, polypeptide analogs thereof and hybrid egf/tgf polypeptides
GB8507666D0 (en) * 1985-03-25 1985-05-01 Wellcome Found Epidermal growth factor production

Also Published As

Publication number Publication date
PT81408A (en) 1985-11-01
ES8802061A1 (en) 1988-03-16
NO862613L (en) 1986-06-27
ES557708A0 (en) 1988-01-01
PH24603A (en) 1990-08-17
AU600433B2 (en) 1990-08-16
NZ213984A (en) 1991-05-28
WO1986002650A1 (en) 1986-05-09
AU4868785A (en) 1986-05-15
AU633377B2 (en) 1993-01-28
NO862613D0 (en) 1986-06-27
ES557145A0 (en) 1987-08-16
AU6655190A (en) 1991-01-24
ES8801378A1 (en) 1988-01-01
ES554629A0 (en) 1988-04-01
FI862734A (en) 1986-06-26
PT81408B (en) 1987-11-11
ES8802185A1 (en) 1988-04-01
FI862734A0 (en) 1986-06-26
JPS62501071A (en) 1987-04-30
PH25794A (en) 1991-11-05
ES557710A0 (en) 1988-01-01
ES8801379A1 (en) 1988-01-01
EP0199769A1 (en) 1986-11-05
GR852610B (en) 1986-03-04
IL76866A0 (en) 1986-02-28
ES554630A0 (en) 1988-03-16
ES8802074A1 (en) 1988-03-16
EP0199769A4 (en) 1989-11-29
ES8707741A1 (en) 1987-08-16
ES548316A0 (en) 1987-01-16
ES554628A0 (en) 1988-03-16

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970401