ES8706709A1 - Procedimiento de obtencion de complejos de tecnecio. - Google Patents

Procedimiento de obtencion de complejos de tecnecio.

Info

Publication number
ES8706709A1
ES8706709A1 ES535587A ES535587A ES8706709A1 ES 8706709 A1 ES8706709 A1 ES 8706709A1 ES 535587 A ES535587 A ES 535587A ES 535587 A ES535587 A ES 535587A ES 8706709 A1 ES8706709 A1 ES 8706709A1
Authority
ES
Spain
Prior art keywords
oxygen
phosphorus
bonded
carbon
set forth
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES535587A
Other languages
English (en)
Other versions
ES535587A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Publication of ES8706709A1 publication Critical patent/ES8706709A1/es
Publication of ES535587A0 publication Critical patent/ES535587A0/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0476—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from monodendate ligands, e.g. sestamibi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0489—Phosphates or phosphonates, e.g. bone-seeking phosphonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/141—Esters of phosphorous acids
    • C07F9/142—Esters of phosphorous acids with hydroxyalkyl compounds without further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/48—Phosphonous acids R—P(OH)2; Thiophosphonous acids including RHP(=O)(OH); Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/6574—Esters of oxyacids of phosphorus
    • C07F9/65748—Esters of oxyacids of phosphorus the cyclic phosphorus atom belonging to more than one ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Abstract

PROCEDIMIENTO PARA OBTENER COMPLEJOS DE TECNECIO. CONSISTE EN HACER REACCIONAR A UN COMPUESTO DE ORGANO FOSFOR TRIVALENTE TRISUSTITUIDO CON PERTECNATO ANHIDRO, EN TOLUENO, ENTRE 2 Y 100GC DURANTE VARIAS HORAS, PARA OBTENER UN COMPLEJO DE 99 TC [P(R ELEVADO A 1, R ELEVADO A 2, R ELEVADO A 3)]6 ELEVADO A + A ELEVADO A -. EL COMPUESTO DE ORGANO DE FOSFORO SE ELIGE ENTRE (CH3O)3 P Y (CH3O)2PCH3. SIENDO: A ELEVADO A-, C1 ELEVADO A -, H2PO4 Y PO4 ELEVADO A 3 Y R ELEVADO A 1, R ELEVADO A 2, R ELEVADO A 3, ALQUILO INFERIOR, ALCOXI INFERIOR Y OTROS. SE UTILIZAN COMO AGENTES FORMADORES DE IMAGEN DE DIAGNOSTICOS DE MEDICINA.
ES535587A 1983-09-01 1984-08-31 Procedimiento de obtencion de complejos de tecnecio. Expired ES8706709A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/528,487 US4582700A (en) 1983-09-01 1983-09-01 Products and processes

Publications (2)

Publication Number Publication Date
ES8706709A1 true ES8706709A1 (es) 1987-06-16
ES535587A0 ES535587A0 (es) 1987-06-16

Family

ID=24105871

Family Applications (1)

Application Number Title Priority Date Filing Date
ES535587A Expired ES8706709A1 (es) 1983-09-01 1984-08-31 Procedimiento de obtencion de complejos de tecnecio.

Country Status (8)

Country Link
US (1) US4582700A (es)
EP (1) EP0136036B1 (es)
JP (1) JPS6072894A (es)
AT (1) ATE42898T1 (es)
AU (1) AU569751B2 (es)
CA (1) CA1220784A (es)
DE (1) DE3478086D1 (es)
ES (1) ES8706709A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE32826E (en) * 1982-08-02 1989-01-10 E. I Du Pont De Nemours And Company Cationic technetium complexes useful as radiodiagnostic agents
US5175343A (en) * 1985-01-14 1992-12-29 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
US4897255A (en) * 1985-01-14 1990-01-30 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
US4795626A (en) * 1985-05-10 1989-01-03 University Of Cincinnati 99m Tc.sup.(III) myocardial imaging agents which are non-reducable in vivo
AU641361B2 (en) * 1988-05-02 1993-09-23 Zynaxis Technologies, Incorporated Compounds, compositions and method for binding bio-affecting substances to surface membranes of bio-particles
US5089249A (en) * 1988-06-10 1992-02-18 Neorx Corporation Conjugates for bone imaging and bone cancer therapy
US5202109A (en) * 1988-06-10 1993-04-13 Neorx Corporation Conjugates for bone imaging and bone cancer therapy
WO1996039622A1 (en) * 1995-06-05 1996-12-12 Mallinckrodt Medical, Inc. Method for measuring intestinal integrity
WO2021032784A1 (en) 2019-08-19 2021-02-25 Nuclear Research And Consultancy Group Platinum isotope combined with bone-targeting agents for use in anticancer drugs

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3987157A (en) * 1974-08-29 1976-10-19 Union Carbide Corporation Technetium 99-m labeled radio-diagnostic agents employing stannous tartrate and method of preparation
US4233284A (en) * 1978-03-31 1980-11-11 The Procter & Gamble Company Stabilized radiographic scanning agents
US4432963A (en) * 1978-07-31 1984-02-21 Mallinckrodt, Inc. Radiographic scanning agent
US4247534A (en) * 1978-07-31 1981-01-27 The Procter & Gamble Company Radiographic scanning agent
US4451450A (en) * 1981-10-15 1984-05-29 New England Nuclear Corporation Cationic compounds useful for making radiodiagnostic agents
US4455291A (en) * 1982-01-22 1984-06-19 New England Nuclear Corporation Accelerators for forming cationic technetium complexes useful as radiodiagnostic agents
US4374821A (en) * 1982-06-28 1983-02-22 E. R. Squibb & Sons, Inc. Myocardial imaging agent and method
US4481184A (en) * 1983-02-14 1984-11-06 E. R. Squibb & Sons, Inc. Cationic technetium (I) complexes

Also Published As

Publication number Publication date
US4582700A (en) 1986-04-15
JPS6072894A (ja) 1985-04-24
EP0136036A3 (en) 1985-07-24
EP0136036B1 (en) 1989-05-10
ES535587A0 (es) 1987-06-16
CA1220784A (en) 1987-04-21
AU569751B2 (en) 1988-02-18
JPH0424356B2 (es) 1992-04-24
EP0136036A2 (en) 1985-04-03
ATE42898T1 (de) 1989-05-15
AU3165284A (en) 1985-03-07
DE3478086D1 (en) 1989-06-15

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970401