ES8706688A1 - Procedimiento selectivo para la preparacion del isosorbido-5-mononitrato - Google Patents

Procedimiento selectivo para la preparacion del isosorbido-5-mononitrato

Info

Publication number
ES8706688A1
ES8706688A1 ES554843A ES554843A ES8706688A1 ES 8706688 A1 ES8706688 A1 ES 8706688A1 ES 554843 A ES554843 A ES 554843A ES 554843 A ES554843 A ES 554843A ES 8706688 A1 ES8706688 A1 ES 8706688A1
Authority
ES
Spain
Prior art keywords
isosorbide
preparation
mononitrate
dinitrate
image
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES554843A
Other languages
English (en)
Other versions
ES554843A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Consiglio Nazionale delle Richerche CNR
Dipharma Francis SRL
Original Assignee
Consiglio Nazionale delle Richerche CNR
Dinamite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Consiglio Nazionale delle Richerche CNR, Dinamite SpA filed Critical Consiglio Nazionale delle Richerche CNR
Publication of ES8706688A1 publication Critical patent/ES8706688A1/es
Publication of ES554843A0 publication Critical patent/ES554843A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

METODO PARA PREPARAR ISOSORBIDO-5-MONONITRATO. CONSISTE EN TRATAR EL ISOSORBIDO-2,5-DINITRATO DE FORMULA (II) EN UN MEDIO DE REACCION CONSTITUIDO POR UN SOLVENTE ORGANICO TAL COMO AGUA, CON UN SISTEMA REDUCTOR EN PRESENCIA DE IONES METALICOS COORDENADORES QUE NO SEAN FACILMENTE OXIDABLES, PARA OBTENER ISOSORBIDO-5-MONONITRATO DE FORMULA (I). EL SISTEMA REDUCTOR ESTA CONSTITUIDO POR UN METAL TAL COMO ZINC Y UN ACIDO DEBIL; Y SE EMPLEA UN CATALIZADOR DE REDUCCION, EFECTUANDOSE LA REACCION A UNA TEMPERATURA COMPRENDIDA ENTRE 0 Y 25GC. TIENEN APLICACIONES FARMACEUTICAS EN EL TRATAMIENTO DE ENFERMEDADES CORONARIAS. *FORMULA*
ES554843A 1985-05-10 1986-05-09 Procedimiento selectivo para la preparacion del isosorbido-5-mononitrato Expired ES8706688A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8520660A IT1208537B (it) 1985-05-10 1985-05-10 Processo per la preparazione dell'isosorbide-5-monoidrato.

Publications (2)

Publication Number Publication Date
ES8706688A1 true ES8706688A1 (es) 1987-07-01
ES554843A0 ES554843A0 (es) 1987-07-01

Family

ID=11170192

Family Applications (1)

Application Number Title Priority Date Filing Date
ES554843A Expired ES8706688A1 (es) 1985-05-10 1986-05-09 Procedimiento selectivo para la preparacion del isosorbido-5-mononitrato

Country Status (4)

Country Link
US (2) US4713466A (es)
DE (1) DE3680703D1 (es)
ES (1) ES8706688A1 (es)
IT (1) IT1208537B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1208537B (it) * 1985-05-10 1989-07-10 Consiglio Nazionale Ricerche Processo per la preparazione dell'isosorbide-5-monoidrato.
US5374539A (en) * 1991-06-17 1994-12-20 Nimni; Marcel E. Process for purifying collagen and generating bioprosthesis
US6239172B1 (en) * 1997-04-10 2001-05-29 Nitrosystems, Inc. Formulations for treating disease and methods of using same
GB9930778D0 (en) * 1999-12-29 2000-02-16 Archimici Ltd Compound synthesis
CN114149447B (zh) * 2021-12-15 2023-11-03 山东致泰医药技术有限公司 一种5-单硝酸异山梨酯的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2500835A1 (fr) * 1981-02-27 1982-09-03 Poudres & Explosifs Ste Nale Procede de synthese des mononitrates d'isosorbide
IT1208537B (it) * 1985-05-10 1989-07-10 Consiglio Nazionale Ricerche Processo per la preparazione dell'isosorbide-5-monoidrato.

Also Published As

Publication number Publication date
IT1208537B (it) 1989-07-10
DE3680703D1 (de) 1991-09-12
US4713466A (en) 1987-12-15
US4777274A (en) 1988-10-11
IT8520660A0 (it) 1985-05-10
ES554843A0 (es) 1987-07-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20070430