ES8706671A1 - Un procedimiento para la preparacion de acarbapenems - Google Patents

Un procedimiento para la preparacion de acarbapenems

Info

Publication number
ES8706671A1
ES8706671A1 ES554468A ES554468A ES8706671A1 ES 8706671 A1 ES8706671 A1 ES 8706671A1 ES 554468 A ES554468 A ES 554468A ES 554468 A ES554468 A ES 554468A ES 8706671 A1 ES8706671 A1 ES 8706671A1
Authority
ES
Spain
Prior art keywords
elevated
formula
translation
procedure
machine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES554468A
Other languages
English (en)
Other versions
ES554468A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ES8706671A1 publication Critical patent/ES8706671A1/es
Publication of ES554468A0 publication Critical patent/ES554468A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR CARBAPENEMS. CONSISTE EN HACER REACCIONAR A UN COMPUESTO DE FORMULA (II) CON UN TIOL DE FORMULA (III), EN PRESENCIA DE HIDROXIDO SODICO, EN TOLUENO O BENCENO Y ENTRE -15 Y +15GC, PARA OBTENER UN COMPUESTO DE FORMULA (I) Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. SIENDO: A, ALQUILENO DE C 1 A 6 DE CADENA LINEAL; R ELEVADO A 1 Y R ELEVADO A 15, H, ALQUILO DE C 1 A 10, CICLOALQUILO DE C 3 A 6 Y OTROS; R ELEVADO A 2, H, UNA CARGA ANIONICA Y OTROS; R ELEVADO A 2'', UN GRUPO PROTECTOR DE CARBOXILO; R ELEVADO A 5, ALQUILO DE C 1 A 6 SUSTITUIDOS CON AMINO O CLORO; R ELEVADO A 8, H; Y L, HA1, BENCENOSULFONILOXI Y OTROS. SE UTILIZA PARA EL TRATAMIENTO DE ENFERMEDADES INFECCIOSAS EN EL HOMBRE Y ANIMALES PRODUCIDAS POR BACTERIAS GRAM (+) Y GRAM (-). *FORMULA*
ES554468A 1985-04-29 1986-04-28 Un procedimiento para la preparacion de acarbapenems Expired ES8706671A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US72800985A 1985-04-29 1985-04-29

Publications (2)

Publication Number Publication Date
ES8706671A1 true ES8706671A1 (es) 1987-07-01
ES554468A0 ES554468A0 (es) 1987-07-01

Family

ID=24925057

Family Applications (1)

Application Number Title Priority Date Filing Date
ES554468A Expired ES8706671A1 (es) 1985-04-29 1986-04-28 Un procedimiento para la preparacion de acarbapenems

Country Status (12)

Country Link
KR (1) KR860008183A (es)
CA (1) CA1273014A (es)
CS (1) CS261240B2 (es)
DK (1) DK193886A (es)
ES (1) ES8706671A1 (es)
FI (1) FI861721A (es)
GR (1) GR861150B (es)
HU (1) HU197904B (es)
LU (1) LU86410A1 (es)
NO (1) NO861667L (es)
OA (1) OA08240A (es)
YU (1) YU150986A (es)

Also Published As

Publication number Publication date
CS261240B2 (en) 1989-01-12
HU197904B (en) 1989-06-28
YU150986A (en) 1987-12-31
DK193886D0 (da) 1986-04-28
GR861150B (en) 1986-09-02
NO861667L (no) 1986-10-30
FI861721A0 (fi) 1986-04-24
CA1273014A (en) 1990-08-21
HUT41792A (en) 1987-05-28
DK193886A (da) 1986-10-30
ES554468A0 (es) 1987-07-01
KR860008183A (ko) 1986-11-12
LU86410A1 (fr) 1986-11-05
FI861721A (fi) 1986-10-30
OA08240A (en) 1987-10-30
CS311886A2 (en) 1988-04-15

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