ES8705372A1 - Ethylenediamine monoamides - Google Patents
Ethylenediamine monoamidesInfo
- Publication number
- ES8705372A1 ES8705372A1 ES546482A ES546482A ES8705372A1 ES 8705372 A1 ES8705372 A1 ES 8705372A1 ES 546482 A ES546482 A ES 546482A ES 546482 A ES546482 A ES 546482A ES 8705372 A1 ES8705372 A1 ES 8705372A1
- Authority
- ES
- Spain
- Prior art keywords
- monoamides
- ethylenediamine
- compounds
- parkinsonism
- interesting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Abstract
Compounds of the formula < IMAGE > I wherein R is an aromatic, 5- or 6-membered heterocyclic residue, as described herein, and their pharmaceutically usable acid addition salts are described. These compounds have interesting monoamine oxidase inhibiting properties with low toxicity and can accordingly be used for the treatment of depressive states and parkinsonism.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH4132/84A CH661043A5 (en) | 1984-08-29 | 1984-08-29 | Ethylenediamine monoamide derivatives |
CH2404/85A CH664755A5 (en) | 1985-06-05 | 1985-06-05 | Use of 1-heterocyclic acyl ethylene di:amine derivs. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES546482A0 ES546482A0 (en) | 1987-05-01 |
ES8705372A1 true ES8705372A1 (en) | 1987-05-01 |
Family
ID=25690366
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES546482A Expired ES8705372A1 (en) | 1984-08-29 | 1985-08-28 | Ethylenediamine monoamides |
ES552399A Expired ES8800158A1 (en) | 1984-08-29 | 1986-02-17 | Ethylenediamine monoamides |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES552399A Expired ES8800158A1 (en) | 1984-08-29 | 1986-02-17 | Ethylenediamine monoamides |
Country Status (28)
Country | Link |
---|---|
US (1) | US4764522A (en) |
JP (2) | JPH0764817B2 (en) |
KR (1) | KR920007269B1 (en) |
AR (1) | AR244209A1 (en) |
AT (1) | AT391694B (en) |
AU (1) | AU582381B2 (en) |
BE (1) | BE903110A (en) |
BG (1) | BG60401B1 (en) |
CA (1) | CA1261335A (en) |
DE (1) | DE3530046C2 (en) |
DK (1) | DK162888C (en) |
ES (2) | ES8705372A1 (en) |
FI (1) | FI83511C (en) |
FR (1) | FR2569694B1 (en) |
GB (1) | GB2163746B (en) |
GR (1) | GR852071B (en) |
HU (1) | HU197309B (en) |
IE (1) | IE58788B1 (en) |
IL (1) | IL76176A (en) |
IT (1) | IT1190385B (en) |
LU (1) | LU86049A1 (en) |
MC (1) | MC1696A1 (en) |
NL (1) | NL193583C (en) |
NO (1) | NO169711C (en) |
NZ (1) | NZ213193A (en) |
PH (1) | PH22813A (en) |
PT (1) | PT81041B (en) |
SE (1) | SE464083B (en) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5204482A (en) * | 1988-07-28 | 1993-04-20 | Hoffman-Laroche Inc. | Compounds for treating and preventing cognitive diseases and depression and methods of making same |
EP0352581A3 (en) * | 1988-07-28 | 1990-07-04 | F. Hoffmann-La Roche Ag | Ethylene diaminmonoamide derivatives |
CA2245055C (en) * | 1989-02-28 | 2003-03-25 | F. Hoffmann-La Roche Ag | Amidation of pyridines |
EP0451790A1 (en) * | 1990-04-12 | 1991-10-16 | Hoechst Aktiengesellschaft | 3,5-disubstituted 2-isoxazolines and isoxazoles, process for their preparation, medicines containing them and their use |
JPH04295470A (en) * | 1991-03-22 | 1992-10-20 | Wakamoto Pharmaceut Co Ltd | 1,2,4-oxadiazole derivative having monoamine oxidase b enzyme inhibiting activity and its production |
US5545658A (en) * | 1991-03-26 | 1996-08-13 | Hoffman-La Roche Inc. | Amino acid derivatives |
UA39849C2 (en) * | 1991-03-26 | 2001-07-16 | Ф.Хоффманн-Ля Рош Аг | DERIVATIVES OF N-ACYL- <font face = "Symbol"> a </font> -AMINO ACIDS OR THEIR PHYSIOLOGICALLY ACCEPTABLE SALTS, SIMPLE OR COMPLEX ETHERS, AMIDICES OR HYMICHIDICS OR |
FR2803592A1 (en) * | 2000-01-06 | 2001-07-13 | Aventis Cropscience Sa | NOVEL DERIVATIVES OF 3-HYDROXYPICOLINIC ACID, PROCESS FOR THEIR PREPARATION AND FUNGICIDAL COMPOSITIONS CONTAINING SAME |
WO2003053997A2 (en) * | 2001-12-06 | 2003-07-03 | Fibrogen, Inc. | Methods of increasing endogenous erythropoietin (epo) |
US6667327B2 (en) * | 2002-02-04 | 2003-12-23 | Hoffmann-La Roche Inc. | Pyridine amido derivatives |
CN100441188C (en) * | 2003-10-23 | 2008-12-10 | 弗·哈夫曼-拉罗切有限公司 | Benzazepine derivatives as MAO-B inhibitors |
US8138209B2 (en) * | 2005-07-13 | 2012-03-20 | Jenrin Discovery, Inc. | Substituted picolinamides as MAO-B inhibitors useful for treating obesity |
WO2008010796A1 (en) * | 2006-07-18 | 2008-01-24 | Renaissance Medicine, Llc | Process for preparing pyridine-2-carboxamides and intermediates therefor |
WO2008010794A1 (en) * | 2006-07-18 | 2008-01-24 | Renaissance Medicine, Llc | Pharmaceutical preparations of crystalline lazabemide |
FR2904317A1 (en) * | 2006-07-27 | 2008-02-01 | Inst Nat Sante Rech Med | ANALOGUES OF HALOGENOBENZAMIDES BRANDED AS RADIOPHARMACEUTICALS |
EP2085390A1 (en) | 2008-01-31 | 2009-08-05 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Labelled analogues of halobenzamides as multimodal radiopharmaceuticals and their precursors |
WO2011028740A1 (en) * | 2009-09-03 | 2011-03-10 | Glaxo Group Limited | ENaC BLOCKERS |
LT3007695T (en) * | 2013-06-13 | 2024-03-25 | Akebia Therapeutics, Inc. | Compositions and methods for treating anemia |
CR20170450A (en) | 2015-04-01 | 2018-04-03 | Akebia Therapeutics Inc | COMPOSITIONS AND METHODS FOR THE TREATMENT OF THE ANEMIA |
WO2019028150A1 (en) | 2017-08-01 | 2019-02-07 | Akebia Therapeutics, Inc. | Compositions for use in methods of treatment of hemoglobin disorders |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB451304A (en) * | 1934-07-07 | 1936-08-04 | Karl Merck | Process for the manufacture of new derivatives of pyrazinemonocarboxylic acid |
DE1217385B (en) * | 1962-11-09 | 1966-05-26 | J. R. Geigy A.-G., Basel (Schweiz) | Process for the production of new picolinic acid derivatives |
NL6707566A (en) * | 1966-08-17 | 1968-02-19 | ||
GB1509527A (en) * | 1974-06-05 | 1978-05-04 | Ici Ltd | 1-(aryl-or heteroaryl)oxy-3-(substituted-amino)propan-2-ol derivatives processes for their manufacture and pharmaceutical compositions containing them |
US4041032A (en) * | 1974-01-16 | 1977-08-09 | Yamanouchi Pharmaceutical Co., Ltd. | Pyrazine derivatives |
GB1509300A (en) * | 1975-12-05 | 1978-05-04 | Ici Ltd | Ethanolamine derivatives |
DE3239573A1 (en) * | 1981-10-28 | 1983-05-19 | Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz | Substituted picolinic acids, process for their preparation, their use and medicaments containing them |
IE54220B1 (en) * | 1981-12-23 | 1989-07-19 | Ici Plc | Phenol esters |
CH653670A5 (en) * | 1983-03-03 | 1986-01-15 | Hoffmann La Roche | BENZAMIDE DERIVATIVES. |
-
1985
- 1985-07-17 CA CA000486984A patent/CA1261335A/en not_active Expired
- 1985-08-05 IT IT21865/85A patent/IT1190385B/en active
- 1985-08-15 FI FI853140A patent/FI83511C/en not_active IP Right Cessation
- 1985-08-16 US US06/766,364 patent/US4764522A/en not_active Expired - Lifetime
- 1985-08-21 LU LU86049A patent/LU86049A1/en unknown
- 1985-08-22 DE DE3530046A patent/DE3530046C2/en not_active Expired - Lifetime
- 1985-08-22 NZ NZ213193A patent/NZ213193A/en unknown
- 1985-08-23 BE BE0/215498A patent/BE903110A/en not_active IP Right Cessation
- 1985-08-23 IL IL76176A patent/IL76176A/en not_active IP Right Cessation
- 1985-08-26 AU AU46636/85A patent/AU582381B2/en not_active Expired
- 1985-08-26 HU HU853224A patent/HU197309B/en not_active IP Right Cessation
- 1985-08-27 MC MC851793A patent/MC1696A1/en unknown
- 1985-08-27 KR KR1019850006181A patent/KR920007269B1/en not_active IP Right Cessation
- 1985-08-27 AR AR85301429A patent/AR244209A1/en active
- 1985-08-27 GR GR852071A patent/GR852071B/el unknown
- 1985-08-27 FR FR858512792A patent/FR2569694B1/en not_active Expired - Lifetime
- 1985-08-28 NO NO853390A patent/NO169711C/en not_active IP Right Cessation
- 1985-08-28 AT AT0251585A patent/AT391694B/en not_active IP Right Cessation
- 1985-08-28 ES ES546482A patent/ES8705372A1/en not_active Expired
- 1985-08-28 GB GB08521358A patent/GB2163746B/en not_active Expired
- 1985-08-28 PH PH32711A patent/PH22813A/en unknown
- 1985-08-28 DK DK391485A patent/DK162888C/en not_active IP Right Cessation
- 1985-08-28 PT PT81041A patent/PT81041B/en not_active IP Right Cessation
- 1985-08-28 SE SE8504014A patent/SE464083B/en not_active IP Right Cessation
- 1985-08-28 IE IE211885A patent/IE58788B1/en not_active IP Right Cessation
- 1985-08-29 JP JP60188723A patent/JPH0764817B2/en not_active Expired - Lifetime
- 1985-08-29 NL NL8502374A patent/NL193583C/en not_active IP Right Cessation
-
1986
- 1986-02-17 ES ES552399A patent/ES8800158A1/en not_active Expired
-
1992
- 1992-07-17 BG BG96645A patent/BG60401B1/en unknown
-
1995
- 1995-01-17 JP JP7020913A patent/JPH0825879B2/en not_active Expired - Lifetime
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20070113 |