ES8704910A1 - Process for the preparation of 3, 5-diamino-1,2,4-triazole derivatives - Google Patents
Process for the preparation of 3, 5-diamino-1,2,4-triazole derivativesInfo
- Publication number
- ES8704910A1 ES8704910A1 ES551388A ES551388A ES8704910A1 ES 8704910 A1 ES8704910 A1 ES 8704910A1 ES 551388 A ES551388 A ES 551388A ES 551388 A ES551388 A ES 551388A ES 8704910 A1 ES8704910 A1 ES 8704910A1
- Authority
- ES
- Spain
- Prior art keywords
- general formula
- image
- compound
- preparation
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/14—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Abstract
There is disclosed a process for the preparation of compounds of the general Formula I < IMAGE > wherein R<1> and R<2> are independently hydrogen, alkyl, alkenyl, aralkyl or cycloalkyl or R1 and R2, together with the adjacent nitrogen atom they are attached to, may form a heterocyclic ring and R3 is hydrogen or alkyl and pharmaceutically acceptable acid addition salts thereof, which comprises reacting a halogen compound of the general Formula III < IMAGE > [wherein X is halogen, which may be prepared from the hydroxy compound of general formula II, with an alkali metal of alkaline earth metal salt of a phenol derivatives of the general Formula IV < IMAGE > and, if desired, converting the compound of general Formula I thus obtained into a pharmaceutically acceptable acid addition salt thereof. The compounds of general Formula I have a useful sustained histamine H2 blocking effect. The advantages of the process invention are that it requires readily available starting materials, provides high yields and is readily feasible on an industrial scale.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU85315A HU193253B (en) | 1985-01-29 | 1985-01-29 | Process for preparing 3,5-diamino-1,2,4-triazole derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8704910A1 true ES8704910A1 (en) | 1987-04-16 |
| ES551388A0 ES551388A0 (en) | 1987-04-16 |
Family
ID=10949054
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES551388A Expired ES8704910A1 (en) | 1985-01-29 | 1986-01-29 | Process for the preparation of 3, 5-diamino-1,2,4-triazole derivatives |
Country Status (18)
| Country | Link |
|---|---|
| JP (1) | JPS61176576A (en) |
| CN (1) | CN1015456B (en) |
| AR (1) | AR240046A1 (en) |
| AT (1) | AT395149B (en) |
| CA (1) | CA1285568C (en) |
| CS (1) | CS253739B2 (en) |
| DD (1) | DD242807A5 (en) |
| DE (1) | DE3602648A1 (en) |
| DK (1) | DK42986A (en) |
| ES (1) | ES8704910A1 (en) |
| FI (1) | FI860432A (en) |
| GB (1) | GB2170805B (en) |
| HU (1) | HU193253B (en) |
| IT (1) | IT1190608B (en) |
| NO (1) | NO167091C (en) |
| PL (1) | PL146491B1 (en) |
| PT (1) | PT81935B (en) |
| SE (1) | SE8600385L (en) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2023133B (en) * | 1978-04-26 | 1982-09-08 | Glaxo Group Ltd | Heterocyclic derivatives |
| DE3070073D1 (en) * | 1979-10-22 | 1985-03-14 | Glaxo Group Ltd | 1,2,4-triazole derivatives, processes for their production and pharmaceutical compositions containing them |
| DK558181A (en) * | 1981-01-30 | 1982-07-31 | Smithkline Corp | METHOD OF PREPARING 3,5-DIAMINO-1,2,4-TRIAZOLES |
| DE3336410A1 (en) * | 1983-10-06 | 1985-04-18 | Ludwig Heumann & Co GmbH, 8500 Nürnberg | SULFEN AMIDE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
| DE3341750A1 (en) * | 1983-11-18 | 1985-05-30 | Ludwig Heumann & Co GmbH, 8500 Nürnberg | 1,2,4-Triazole derivatives, process for their preparation and medicaments containing these compounds |
-
1985
- 1985-01-29 HU HU85315A patent/HU193253B/en unknown
-
1986
- 1986-01-19 IT IT19218/86A patent/IT1190608B/en active
- 1986-01-27 CS CS86576A patent/CS253739B2/en unknown
- 1986-01-29 DK DK42986A patent/DK42986A/en not_active Application Discontinuation
- 1986-01-29 DE DE19863602648 patent/DE3602648A1/en active Granted
- 1986-01-29 CN CN86100724A patent/CN1015456B/en not_active Expired
- 1986-01-29 CA CA000500565A patent/CA1285568C/en not_active Expired - Lifetime
- 1986-01-29 PT PT81935A patent/PT81935B/en not_active IP Right Cessation
- 1986-01-29 SE SE8600385A patent/SE8600385L/en not_active Application Discontinuation
- 1986-01-29 AR AR302989A patent/AR240046A1/en active
- 1986-01-29 DD DD86286590A patent/DD242807A5/en not_active IP Right Cessation
- 1986-01-29 FI FI860432A patent/FI860432A/en not_active Application Discontinuation
- 1986-01-29 ES ES551388A patent/ES8704910A1/en not_active Expired
- 1986-01-29 NO NO860324A patent/NO167091C/en unknown
- 1986-01-29 GB GB08602136A patent/GB2170805B/en not_active Expired
- 1986-01-29 AT AT0021086A patent/AT395149B/en not_active IP Right Cessation
- 1986-01-29 JP JP61017700A patent/JPS61176576A/en active Granted
- 1986-01-29 PL PL1986257689A patent/PL146491B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI860432A0 (en) | 1986-01-29 |
| JPS61176576A (en) | 1986-08-08 |
| GB8602136D0 (en) | 1986-03-05 |
| CN86100724A (en) | 1986-08-13 |
| CA1285568C (en) | 1991-07-02 |
| CN1015456B (en) | 1992-02-12 |
| AR240046A1 (en) | 1990-01-31 |
| DD242807A5 (en) | 1987-02-11 |
| HU193253B (en) | 1987-08-28 |
| PT81935B (en) | 1987-11-30 |
| PL257689A1 (en) | 1987-02-09 |
| IT1190608B (en) | 1988-02-16 |
| ATA21086A (en) | 1992-02-15 |
| AT395149B (en) | 1992-09-25 |
| NO167091C (en) | 1991-10-02 |
| FI860432A (en) | 1986-07-30 |
| SE8600385D0 (en) | 1986-01-29 |
| NO167091B (en) | 1991-06-24 |
| ES551388A0 (en) | 1987-04-16 |
| CS253739B2 (en) | 1987-12-17 |
| GB2170805B (en) | 1988-04-27 |
| GB2170805A (en) | 1986-08-13 |
| SE8600385L (en) | 1986-07-30 |
| PL146491B1 (en) | 1989-02-28 |
| PT81935A (en) | 1986-02-01 |
| DK42986A (en) | 1986-07-30 |
| JPH0524906B2 (en) | 1993-04-09 |
| IT8619218A0 (en) | 1986-01-19 |
| DK42986D0 (en) | 1986-01-29 |
| NO860324L (en) | 1986-07-30 |
| DE3602648A1 (en) | 1986-09-11 |
| DE3602648C2 (en) | 1990-09-06 |
| HUT40632A (en) | 1987-01-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970401 |