ES8700268A1 - Un procedimiento para la preparacion de compuestos de eritromicina 6-0, 11-0, 6-11-di-0-alquilados. - Google Patents

Un procedimiento para la preparacion de compuestos de eritromicina 6-0, 11-0, 6-11-di-0-alquilados.

Info

Publication number
ES8700268A1
ES8700268A1 ES546065A ES546065A ES8700268A1 ES 8700268 A1 ES8700268 A1 ES 8700268A1 ES 546065 A ES546065 A ES 546065A ES 546065 A ES546065 A ES 546065A ES 8700268 A1 ES8700268 A1 ES 8700268A1
Authority
ES
Spain
Prior art keywords
macrolide
hydroxyl groups
alkylation process
alkylation
macrolides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES546065A
Other languages
English (en)
Other versions
ES546065A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of ES8700268A1 publication Critical patent/ES8700268A1/es
Publication of ES546065A0 publication Critical patent/ES546065A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS 6-0. 11-0 Y 6,11-DI-0-ALQUILADOS DE ERITROMICINA. CONSISTE EN LA ESTERIFICACION DEL GRUPO 2K-HIDROXILO DE LA ERITROMICINA POR REACCION CON UN AGENTE ACILANTE DE FORMULA X-R-COY, EN LA QUE Y REPRESENTA CLORO, BROMO O FLUOR, X ES HIDROGENO O UN GRUPO ACILO TERMINAL, Y R PUEDE SER UNO DE VARIOS TIPOS DE RADICALES; SEGUIDA DE LA ALQUILACION EN UNO O MAS DE LOS GRUPOS HIDROXILO RESTANTES POR REACCION CON UN HALOGENURO DE ALQUILO, COMO YODURO DE METILO, EN PRESENCIA DE UNA BASE FUERTE, COMO HIDRURO SODICO, EN UN DISOLVENTE INERTE, A UNA TEMPERATURA COMPRENDIDA ENTRE C27JC Y 0JC. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTIBACTERIANA.
ES546065A 1984-08-31 1985-08-09 Un procedimiento para la preparacion de compuestos de eritromicina 6-0, 11-0, 6-11-di-0-alquilados. Expired ES8700268A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US64655884A 1984-08-31 1984-08-31

Publications (2)

Publication Number Publication Date
ES8700268A1 true ES8700268A1 (es) 1986-09-16
ES546065A0 ES546065A0 (es) 1986-09-16

Family

ID=24593519

Family Applications (1)

Application Number Title Priority Date Filing Date
ES546065A Expired ES8700268A1 (es) 1984-08-31 1985-08-09 Un procedimiento para la preparacion de compuestos de eritromicina 6-0, 11-0, 6-11-di-0-alquilados.

Country Status (9)

Country Link
EP (1) EP0177696A1 (es)
JP (1) JPS6160694A (es)
KR (1) KR860001830A (es)
AU (2) AU4613285A (es)
DK (1) DK357685A (es)
ES (1) ES8700268A1 (es)
GR (1) GR852065B (es)
IL (1) IL75908A0 (es)
ZA (1) ZA856086B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60214796A (ja) * 1984-04-06 1985-10-28 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシン類の製法
JPS61200998A (ja) * 1985-03-01 1986-09-05 Taisho Pharmaceut Co Ltd エリスロマイシンエステル誘導体
JP3063943B2 (ja) * 1992-02-26 2000-07-12 明治製菓株式会社 血漿中において抗菌活性の持続する新規１６員環マクロリド誘導体及びその合成中間体とそれらの製造法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4331803A (en) * 1980-06-04 1982-05-25 Taisho Pharmaceutical Co., Ltd. Novel erythromycin compounds
JPS5896095A (ja) * 1981-11-30 1983-06-07 Taisho Pharmaceut Co Ltd １１−ｏ−アルキルエリスロマイシンａ誘導体
JPS5896097A (ja) * 1981-12-01 1983-06-07 Taisho Pharmaceut Co Ltd エリスロマイシンｂ誘導体
US4429116A (en) * 1982-12-27 1984-01-31 Pfizer Inc. Alkylated oleandomycin containing compounds

Also Published As

Publication number Publication date
IL75908A0 (en) 1985-12-31
DK357685D0 (da) 1985-08-06
KR860001830A (ko) 1986-03-22
EP0177696A1 (en) 1986-04-16
GR852065B (es) 1985-12-30
JPS6160694A (ja) 1986-03-28
AU7093287A (en) 1987-07-23
DK357685A (da) 1986-03-01
ZA856086B (en) 1986-03-26
AU4613285A (en) 1986-03-06
ES546065A0 (es) 1986-09-16

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