ES8608491A1 - Procedimiento para la preparacion de derivados de pirazol - Google Patents

Procedimiento para la preparacion de derivados de pirazol

Info

Publication number
ES8608491A1
ES8608491A1 ES547810A ES547810A ES8608491A1 ES 8608491 A1 ES8608491 A1 ES 8608491A1 ES 547810 A ES547810 A ES 547810A ES 547810 A ES547810 A ES 547810A ES 8608491 A1 ES8608491 A1 ES 8608491A1
Authority
ES
Spain
Prior art keywords
pyrazole derivatives
receptors
compounds
preparation
hydrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES547810A
Other languages
English (en)
Other versions
ES547810A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Heumann Ludwig and Co GmbH
Original Assignee
Heumann Ludwig and Co GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heumann Ludwig and Co GmbH filed Critical Heumann Ludwig and Co GmbH
Publication of ES547810A0 publication Critical patent/ES547810A0/es
Publication of ES8608491A1 publication Critical patent/ES8608491A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/44—Oxygen and nitrogen or sulfur and nitrogen atoms
    • C07D231/52—Oxygen atom in position 3 and nitrogen atom in position 5, or vice versa
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS ESPECIALES DE PIRAZOL, DE FORMULA GENERAL (I), EN QUE R1 Y R2 INDEPENDIENTEMENTE UNO DE OTRO, SIGNIFICAN UN ATOMO DE H O UN GRUPO ALQUILO C1-C3 LINEAL O DE CADENA RAMIFICADA. JUNTO CON EL N, R1 Y R2 PUEDEN FORMAR UN ANILLO HETEROCICLICO. R3 SIGNIFICA UN ATOMO DE H O UN GRUPO METILO O ETILO Y N ES UN NUMERO ENTERO DE 2 A 6. PARA LA OBTENCION SE HACE REACCIONAR UN COMPUESTO DE FORMULA GENERAL (II) EN QUE R1, R2, R3 Y N TIENEN LOS SIGNIFICADOS ANTERIORES, EN UNA SOLUCION ACUOSA ACIDA A TEMPERATURA DE REFLUJO. EL AISLAMIENTO DEL COMPUESTO OBTENIDO SE EFECTUA MEDIANTE PURIFICACION POR CROMATOGRAFIA Y CRISTALIZACION. LOS COMPUESTOS OBTENIDOS PUEDEN SER FORMULADOS PARA SU ADMINISTRACION POR VIA ORAL, BUCAL, TOPICA, PARENTAL O RECTAL, COMO ANTIULCEROSOS.
ES547810A 1984-10-17 1985-10-11 Procedimiento para la preparacion de derivados de pirazol Expired ES8608491A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843438027 DE3438027A1 (de) 1984-10-17 1984-10-17 Pyrazolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
ES547810A0 ES547810A0 (es) 1986-07-16
ES8608491A1 true ES8608491A1 (es) 1986-07-16

Family

ID=6248096

Family Applications (1)

Application Number Title Priority Date Filing Date
ES547810A Expired ES8608491A1 (es) 1984-10-17 1985-10-11 Procedimiento para la preparacion de derivados de pirazol

Country Status (8)

Country Link
EP (1) EP0181471A1 (es)
JP (1) JPS6197266A (es)
DE (1) DE3438027A1 (es)
DK (1) DK468985A (es)
ES (1) ES8608491A1 (es)
GR (1) GR852483B (es)
IL (1) IL76603A0 (es)
NZ (1) NZ213806A (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230349922A1 (en) 2020-08-11 2023-11-02 Université De Strasbourg H2 Blockers Targeting Liver Macrophages for the Prevention and Treatment of Liver Disease and Cancer

Also Published As

Publication number Publication date
DK468985A (da) 1986-04-18
EP0181471A1 (de) 1986-05-21
IL76603A0 (en) 1986-02-28
DE3438027A1 (de) 1986-04-17
ES547810A0 (es) 1986-07-16
DK468985D0 (da) 1985-10-14
GR852483B (es) 1986-02-26
NZ213806A (en) 1988-05-30
JPS6197266A (ja) 1986-05-15

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