ES8606376A1 - Procedimiento para preparar composiciones farmaceuticas a base de antibioticos de antraciclina - Google Patents

Procedimiento para preparar composiciones farmaceuticas a base de antibioticos de antraciclina

Info

Publication number
ES8606376A1
ES8606376A1 ES528172A ES528172A ES8606376A1 ES 8606376 A1 ES8606376 A1 ES 8606376A1 ES 528172 A ES528172 A ES 528172A ES 528172 A ES528172 A ES 528172A ES 8606376 A1 ES8606376 A1 ES 8606376A1
Authority
ES
Spain
Prior art keywords
hydrogen
acyloxy
hydroxy
halo
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES528172A
Other languages
English (en)
Other versions
ES528172A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ohio State University Research Foundation
Original Assignee
Ohio State University Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ohio State University Research Foundation filed Critical Ohio State University Research Foundation
Publication of ES528172A0 publication Critical patent/ES528172A0/es
Publication of ES8606376A1 publication Critical patent/ES8606376A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR ANTIBIOTICOS DE ANTRACICLINA. CONSISTE EN HACER REACCIONAR UN 1,5-ANHIDRO-2,6-DIDEOXI-HEX-1-ENITOL CON UN 1,4-0-ACIL-AGLICON DE FORMULA (II), EN UNA MEZCLA ANHIDRA DE ACETONITRILO Y TETRAHIDROFURANO, Y EN PRESENCIA DE UN AGENTE HALOGENANTE COMO N-IODOSUCCINIMIDA O N-BROMOSUCCINIMIDA, PARA OBTENER UN COMPUESTO DE FORMULA (I). SIENDO: R1, -OOCR3 O -OOC(CH2)NCOOR4; R2, H, HIDROXI O METOXI; R3 ALQUILO DE C 1 A 8; R4, H, METAL ALCALINO, O ALQUILO DE C 1 A 4; X Y XK, DISTINTOS, HALOGENO E HIDROGENO; Y E YK, DISTINTOS, HIDROGENO E HIDROGENO HIDROXI O ACILOXI; Z Y ZK DISTINTOS, COMO Y E YK; Y N, UN NUMERO ENTERO DE 0 A 6. SE UTILIZAN EN EL TRATAMIENTO DE ESTADOS NEOPLASTICOS, INCLUYENDO LEUCEMIAS MIELOBLASTICAS Y LIMFOBLASTICAS AGUDAS.
ES528172A 1982-12-20 1983-12-19 Procedimiento para preparar composiciones farmaceuticas a base de antibioticos de antraciclina Expired ES8606376A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US45086382A 1982-12-20 1982-12-20

Publications (2)

Publication Number Publication Date
ES528172A0 ES528172A0 (es) 1986-04-16
ES8606376A1 true ES8606376A1 (es) 1986-04-16

Family

ID=23789812

Family Applications (1)

Application Number Title Priority Date Filing Date
ES528172A Expired ES8606376A1 (es) 1982-12-20 1983-12-19 Procedimiento para preparar composiciones farmaceuticas a base de antibioticos de antraciclina

Country Status (15)

Country Link
EP (1) EP0116222A1 (es)
AU (1) AU2216483A (es)
CA (1) CA1209130A (es)
DK (1) DK585183A (es)
ES (1) ES8606376A1 (es)
FI (1) FI834690A (es)
GR (1) GR79729B (es)
HU (1) HUT35269A (es)
IL (1) IL70487A (es)
NO (1) NO834693L (es)
NZ (1) NZ206621A (es)
PH (1) PH18932A (es)
PT (1) PT77838B (es)
YU (1) YU246583A (es)
ZA (1) ZA839396B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8426672D0 (en) * 1984-10-22 1984-11-28 Erba Farmitalia Pharmaceutical compositions
FR2591599B1 (fr) * 1985-12-17 1988-08-05 Hoechst Lab Nouvelles anthracyclines et medicaments les contenant
JPH0660189B2 (ja) * 1986-01-22 1994-08-10 財団法人微生物化学研究会 ２，６−ジデオキシ−２−フルオロ−ｌ−タロピラノ−ス又はその誘導体とその製造法
JPH0742304B2 (ja) * 1986-12-05 1995-05-10 財団法人微生物化学研究会 新規なアンスラサイクリン誘導体およびその製造法
US4863739A (en) * 1987-05-19 1989-09-05 Board Of Regents, The University Of Texas System Liposome compositions of anthracycline derivatives
JPH03502327A (ja) * 1988-01-19 1991-05-30 ボード・オブ・リージェンツ，ザ・ユニバーシティ・オブ・テキサス・システム ３’‐デアミノドキソルビシンのエステル体、そのリポソーム組成物およびその使用方法
WO1990000173A1 (en) * 1988-06-27 1990-01-11 Board Of Regents, The University Of Texas System 4'-deoxy-2'-halo-anthracycline antibiotics, methods for their use, and intermediates and methods for synthesis thereof
DE69103503T2 (de) * 1990-09-28 1995-01-05 Mercian Corp Adriamycinderivate.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4201773A (en) * 1978-07-26 1980-05-06 The United States Of America As Represented By The Department Of Health, Education And Welfare 7-O-(2,6-Dideoxy-α-L-lyxo-hexopyranosyl)-daunomycinone, desmethoxy daunomycinone, adriamycinone, and carminomycinone

Also Published As

Publication number Publication date
DK585183D0 (da) 1983-12-19
FI834690A0 (fi) 1983-12-20
NZ206621A (en) 1986-01-24
ES528172A0 (es) 1986-04-16
PH18932A (en) 1985-11-11
AU2216483A (en) 1984-06-28
ZA839396B (en) 1984-08-29
EP0116222A1 (en) 1984-08-22
FI834690A (fi) 1984-06-21
IL70487A (en) 1986-03-31
IL70487A0 (en) 1984-03-30
HUT35269A (en) 1985-06-28
GR79729B (es) 1984-10-31
CA1209130A (en) 1986-08-05
YU246583A (en) 1986-06-30
PT77838B (en) 1986-03-26
NO834693L (no) 1984-06-21
PT77838A (en) 1984-01-01
DK585183A (da) 1984-06-21

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