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Farmhispania S A Y Bioiberica
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Farmhispania S A Y Bioiberica
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Priority to ES543209ApriorityCriticalpatent/ES8604881A1/en
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Publication of ES543209A0publicationCriticalpatent/ES543209A0/en
1-Cyclopropyl 6-fluoro 1,4-dihydro 4-oxo 7-(1-piperazinyl) quinoline-3-carboxylic acid of formula (I) is made by reacting 7-chloro-1-cyclopropyl 6-fluoro 1,4-dihydro 4-oxo quinoline 3-carboxylic acid (II) with 1,4-bis(trimethylsilyl) piperazine (III) in an inert solvent e.g. CHCl3, CH2Cl2 or acetonitrile, in presence of an aliphatic or aromatic tert. amine, at 0-80 deg.C.
A method for the preparation of derivatives of¹pyridine, quinoline and imidazoline¹unsubstituted 2-carbamoyl nicotinic and¹3-quinolinecarboxylic acids of formula (1).