ES8604112A1 - Procedimiento para producir clorhidrato de l-norcarnitina - Google Patents
Procedimiento para producir clorhidrato de l-norcarnitinaInfo
- Publication number
- ES8604112A1 ES8604112A1 ES545563A ES545563A ES8604112A1 ES 8604112 A1 ES8604112 A1 ES 8604112A1 ES 545563 A ES545563 A ES 545563A ES 545563 A ES545563 A ES 545563A ES 8604112 A1 ES8604112 A1 ES 8604112A1
- Authority
- ES
- Spain
- Prior art keywords
- resin
- mixt
- eluting
- iii
- preparing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Catalysts (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Pyridine Compounds (AREA)
Abstract
PROCEDIMIENTO PARA PRODUCIR CLORHIDRATO DE L-NORCARNITINA. COMPRENDE: A) HACER REACCIONAR UNA MEZCLA DE L-CARNITINA (II) Y 1,4-DIAZABICICLO(2,2,2)OCTANO (III), EN UN DISOLVENTE ORGANICO INERTE A LA REACCION, A LA TEMPERATURA DE REFLUJO DE LA MEZCLA Y DURANTE 2 A 48 HORAS, PARA OBTENER UNA MEZCLA QUE COMPRENDE L-NORCARNITINA (I), EL DERIVADO N-METILICO (IV), EL EXCESO NO REACCIONADO DE (III) Y ALGO DE (II) NO REACCIONADO; B) ENFRIAR LA MEZCLA REACCIONAL DE A) HASTA 4 A 10JC Y SEPARAR POR FILTRACION EL PRECIPITADO; C) DESTILAR EN VACIO EL FILTRADO DE B), PARA OBTENER UNA SOLUCION ACUOSA; D) ELUDIR LA SOLUCION DE C) EN UNA RESINA CAMBIADORA DE IONES BASICA, ACTIVADA EN LA FORMA OHC, CON LO CUAL SE SEPARA (I) QUE QUEDA EN LA RESINA APARTANDOLA DE UN ELUATO QUE COMPRENDE EL (III) RESTANTE, (IV) Y EL (II) NO REACCIONADO; Y E) ELUDIR LA RESINA DE D) CON ACIDO CLORHIDRICO 1N-2N, PARA OBTENER EL CLORHIDRATO DE L-NORCARNITINA (I).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT48660/84A IT1181813B (it) | 1984-07-27 | 1984-07-27 | Procedimento per la preparazione di l-norcarnitina cloridrato |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8604112A1 true ES8604112A1 (es) | 1986-01-16 |
| ES545563A0 ES545563A0 (es) | 1986-01-16 |
Family
ID=11267890
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES545563A Expired ES8604112A1 (es) | 1984-07-27 | 1985-07-26 | Procedimiento para producir clorhidrato de l-norcarnitina |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US4599447A (es) |
| EP (1) | EP0169819B1 (es) |
| JP (1) | JPS6143148A (es) |
| KR (1) | KR920007231B1 (es) |
| AT (1) | ATE31916T1 (es) |
| CA (1) | CA1234578A (es) |
| DE (1) | DE3561392D1 (es) |
| DK (1) | DK342485A (es) |
| ES (1) | ES8604112A1 (es) |
| GR (1) | GR851790B (es) |
| IE (1) | IE58119B1 (es) |
| IL (1) | IL75899A (es) |
| IT (1) | IT1181813B (es) |
| PT (1) | PT80871B (es) |
| YU (1) | YU45729B (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4892961A (en) * | 1985-07-31 | 1990-01-09 | Sumitomo Pharmaceuticals Company, Limited | Amino acid derivatives, and their production |
-
1984
- 1984-07-27 IT IT48660/84A patent/IT1181813B/it active
-
1985
- 1985-06-27 IE IE162485A patent/IE58119B1/en not_active IP Right Cessation
- 1985-06-28 US US06/750,689 patent/US4599447A/en not_active Expired - Fee Related
- 1985-07-03 EP EP85830170A patent/EP0169819B1/en not_active Expired
- 1985-07-03 DE DE8585830170T patent/DE3561392D1/de not_active Expired
- 1985-07-03 AT AT85830170T patent/ATE31916T1/de not_active IP Right Cessation
- 1985-07-05 KR KR1019850004827A patent/KR920007231B1/ko not_active IP Right Cessation
- 1985-07-08 YU YU112585A patent/YU45729B/sh unknown
- 1985-07-08 CA CA000486469A patent/CA1234578A/en not_active Expired
- 1985-07-18 GR GR851790A patent/GR851790B/el unknown
- 1985-07-23 JP JP60163780A patent/JPS6143148A/ja active Pending
- 1985-07-24 IL IL75899A patent/IL75899A/xx not_active IP Right Cessation
- 1985-07-26 ES ES545563A patent/ES8604112A1/es not_active Expired
- 1985-07-26 DK DK342485A patent/DK342485A/da unknown
- 1985-07-26 PT PT80871A patent/PT80871B/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK342485D0 (da) | 1985-07-26 |
| IE58119B1 (en) | 1993-07-14 |
| YU45729B (sh) | 1992-07-20 |
| EP0169819A1 (en) | 1986-01-29 |
| IL75899A (en) | 1988-06-30 |
| EP0169819B1 (en) | 1988-01-13 |
| DE3561392D1 (en) | 1988-02-18 |
| IL75899A0 (en) | 1985-12-31 |
| CA1234578A (en) | 1988-03-29 |
| IT8448660A0 (it) | 1984-07-27 |
| KR860001054A (ko) | 1986-02-22 |
| JPS6143148A (ja) | 1986-03-01 |
| YU112585A (en) | 1987-12-31 |
| PT80871A (en) | 1985-08-01 |
| DK342485A (da) | 1986-01-28 |
| KR920007231B1 (ko) | 1992-08-28 |
| GR851790B (es) | 1985-11-26 |
| US4599447A (en) | 1986-07-08 |
| IT1181813B (it) | 1987-09-30 |
| ES545563A0 (es) | 1986-01-16 |
| IE851624L (en) | 1986-01-27 |
| PT80871B (pt) | 1987-09-18 |
| ATE31916T1 (de) | 1988-01-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970519 |