ES8604104A1 - Un procedimiento para la preparacion de nuevos derivados de feniletanamina - Google Patents

Un procedimiento para la preparacion de nuevos derivados de feniletanamina

Info

Publication number
ES8604104A1
ES8604104A1 ES545776A ES545776A ES8604104A1 ES 8604104 A1 ES8604104 A1 ES 8604104A1 ES 545776 A ES545776 A ES 545776A ES 545776 A ES545776 A ES 545776A ES 8604104 A1 ES8604104 A1 ES 8604104A1
Authority
ES
Spain
Prior art keywords
hydrogen
alkyl
image
hydroxy
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES545776A
Other languages
English (en)
Other versions
ES545776A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB838329490A external-priority patent/GB8329490D0/en
Priority claimed from GB838334294A external-priority patent/GB8334294D0/en
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES8604104A1 publication Critical patent/ES8604104A1/es
Publication of ES545776A0 publication Critical patent/ES545776A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/62—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE FENILETANAMINA Y DE SUS SALES, AMIDAS O ESTERES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R2 ES HIDROGENO O HALOGENO; R4 ES HIDROGENO O ALQUILO C1-6; R6 ES HIDROGENO O METILO; R1, R5 Y R7 PUEDEN SER VARIOS TIPOS DE RADICALES; Y N VALE 1 O 2. CONSISTE ENLA REACCION DE UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III), EN LAS QUE TODOS LOS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO SIGUIENDO METODOS CONVENCIONALES Y EL PRODUCTO FORMADO SE AISLA Y PURIFICA MEDIANTE CRISTALIZACION FRACCIONADA EN UN DISOLVENTE ADECUADO, COMO METANOL, ACETATO DE ETILO O SUS MEZCLAS. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTIHIPERGLICEMICA Y ANTIOBESIDAD.
ES545776A 1983-11-04 1985-07-31 Un procedimiento para la preparacion de nuevos derivados de feniletanamina Expired ES8604104A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB838329490A GB8329490D0 (en) 1983-11-04 1983-11-04 Compounds
GB838334294A GB8334294D0 (en) 1983-12-22 1983-12-22 Compounds

Publications (2)

Publication Number Publication Date
ES8604104A1 true ES8604104A1 (es) 1986-01-16
ES545776A0 ES545776A0 (es) 1986-01-16

Family

ID=26286971

Family Applications (3)

Application Number Title Priority Date Filing Date
ES537359A Expired ES8603377A1 (es) 1983-11-04 1984-11-02 Un procedimiento para la preparacion de nuevos derivados de feniletanamina.
ES545777A Expired ES8607910A1 (es) 1983-11-04 1985-07-31 Un procedimiento para la preparacion de nuevos derivados de feniletanamina
ES545776A Expired ES8604104A1 (es) 1983-11-04 1985-07-31 Un procedimiento para la preparacion de nuevos derivados de feniletanamina

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES537359A Expired ES8603377A1 (es) 1983-11-04 1984-11-02 Un procedimiento para la preparacion de nuevos derivados de feniletanamina.
ES545777A Expired ES8607910A1 (es) 1983-11-04 1985-07-31 Un procedimiento para la preparacion de nuevos derivados de feniletanamina

Country Status (8)

Country Link
US (1) US4803293A (es)
EP (1) EP0142102B1 (es)
AU (1) AU580972B2 (es)
CA (1) CA1246083A (es)
DE (1) DE3466387D1 (es)
ES (3) ES8603377A1 (es)
GR (1) GR80828B (es)
NZ (1) NZ210088A (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4968707A (en) * 1987-06-10 1990-11-06 Pfizer Inc. Oxazolidin-2-one derivatives as hypoglycemic agents
FI892341A (fi) * 1988-06-10 1989-12-11 Hoffmann La Roche Propanolaminderivat.
US5356913A (en) * 1990-02-09 1994-10-18 The Upjohn Company Use of insulin sensitizing agents to treat hypertension
JP3544659B2 (ja) † 1990-02-09 2004-07-21 ファルマシア・アンド・アップジョン・カンパニー インスリン感性化剤類の高血圧治療のための使用
US5563171A (en) * 1993-11-05 1996-10-08 American Cyanamid Company Treatment of glaucoma and ocular hypertension with β3-adrenergic agonists
US5578638A (en) * 1993-11-05 1996-11-26 American Cyanamid Company Treatment of glaucoma and ocular hypertension with β3 -adrenergic agonists

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3678094A (en) * 1970-04-20 1972-07-18 Merck & Co Inc Substituted anilino carboxylic acids
DE2965655D1 (en) * 1978-06-28 1983-07-21 Beecham Group Plc Secondary amines, their preparation, pharmaceutical compositions containing them and their use
DE3061334D1 (en) * 1979-06-16 1983-01-20 Beecham Group Plc Ethanamine derivatives, their preparation and use in pharmaceutical compositions
EP0028105B1 (en) * 1979-10-25 1983-01-19 Beecham Group Plc Secondary amines, their preparation and use in pharmaceutical compositions
DE3226355C2 (de) * 1982-07-14 1984-06-28 Ernst Reime GmbH & Co KG Spezialfabrik für Präzisionsgewindeschneidwerkzeuge, 8500 Nürnberg Gewindebohrer
DE3368258D1 (en) * 1982-07-16 1987-01-22 Beecham Group Plc 2-aminoethyl ether derivatives, processes for their preparation and pharmaceutical compositions containing them
EP0103830A3 (de) * 1982-09-22 1985-07-31 Bayer Ag Wachstumsfördernde Phenylethylamin-Derivate
EP0139921B1 (en) * 1983-08-17 1987-03-25 Beecham Group Plc 2-phenylethylamine derivatives

Also Published As

Publication number Publication date
ES537359A0 (es) 1985-12-16
GR80828B (en) 1985-03-04
AU3492584A (en) 1985-05-09
CA1246083A (en) 1988-12-06
ES545777A0 (es) 1986-06-01
ES8607910A1 (es) 1986-06-01
US4803293A (en) 1989-02-07
EP0142102A3 (en) 1986-04-30
ES545776A0 (es) 1986-01-16
DE3466387D1 (en) 1987-10-29
AU580972B2 (en) 1989-02-09
EP0142102B1 (en) 1987-09-23
NZ210088A (en) 1988-10-28
ES8603377A1 (es) 1985-12-16
EP0142102A2 (en) 1985-05-22

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