ES8603182A1 - Novel 2-substituted ergoline derivatives - Google Patents

Novel 2-substituted ergoline derivatives

Info

Publication number
ES8603182A1
ES8603182A1 ES542069A ES542069A ES8603182A1 ES 8603182 A1 ES8603182 A1 ES 8603182A1 ES 542069 A ES542069 A ES 542069A ES 542069 A ES542069 A ES 542069A ES 8603182 A1 ES8603182 A1 ES 8603182A1
Authority
ES
Spain
Prior art keywords
alkyl
novel
bond
ergoline derivatives
ergolinyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES542069A
Other languages
Spanish (es)
Other versions
ES542069A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of ES8603182A1 publication Critical patent/ES8603182A1/en
Publication of ES542069A0 publication Critical patent/ES542069A0/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
    • C07D457/12—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C07F7/0814—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring is substituted at a C ring atom by Si
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

2-substd. ergoline derivs. of formula (I) and their salts are new. - R2 = COR1, CH=CHCO2R11, CH2CH2COR11, CCR111 HC = CHR111; R1 = OH, 1-4C alkoxy, NH2; R11 = 1-4C alkyl; R111 = H, 1-4C alkyl, Ph, CH2OH COR11, CH2N(R11)2 Si(Me2)R11 R6 = 1-4C alkyl; R8 = Me, NH-CO-NEt2, NH-CS-NEt2; dotted line = 2 single C-C bonds or one single C-C bond and one double C=C bond; and R8 can be either alpha or beta positioned if C-C to which it is attached is a single bond. - 1,1-diethyl-(6-methyl-2 ethinyl-8alpha-ergolinyl) -urea and 1,1,-diethyl-(6-methyl-2-ethyl -8alpha-ergolinyl)urea are specifically claimed.
ES542069A 1984-04-09 1985-04-09 PROCEDURE FOR PREPARING REPLACED ERGOLINS IN POSITION 2 Granted ES542069A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843413659 DE3413659A1 (en) 1984-04-09 1984-04-09 Novel 2-substituted ergoline derivatives

Publications (2)

Publication Number Publication Date
ES8603182A1 true ES8603182A1 (en) 1985-12-16
ES542069A0 ES542069A0 (en) 1985-12-16

Family

ID=6233290

Family Applications (1)

Application Number Title Priority Date Filing Date
ES542069A Granted ES542069A0 (en) 1984-04-09 1985-04-09 PROCEDURE FOR PREPARING REPLACED ERGOLINS IN POSITION 2

Country Status (3)

Country Link
CS (1) CS248738B2 (en)
DE (1) DE3413659A1 (en)
ES (1) ES542069A0 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE107647T1 (en) * 1984-04-09 1994-07-15 Schering Ag 2-SUBSTITUTED ERGOLINE DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS.
DE3528584A1 (en) * 1985-08-06 1987-02-19 Schering Ag NEW 1-ALKYL-ERGOLIN-THIOURINE DERIVATIVES
DE3535929A1 (en) * 1985-10-04 1987-04-09 Schering Ag 1,2-DISUBSTITUTED ERGOL DERIVATIVES
DE3535930A1 (en) * 1985-10-04 1987-04-09 Schering Ag NEW 2-SUBSTITUTED ERGOL DERIVATIVES
DK338789A (en) * 1988-07-15 1990-01-16 Schering Ag 2-SUBSTITUTED ERGOLINYLURINE DERIVATIVES AND PROCEDURES FOR THE PRODUCTION THEREOF, THEIR USE AS MEDICINES AND INTERMEDIATES FOR THE PRODUCTION THEREOF

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3101535A1 (en) * 1981-01-14 1982-08-12 Schering Ag, 1000 Berlin Und 4619 Bergkamen NEW (2-HALOGEN-ERGOLINYL) -N'.N'-DIETHYL-UREA DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A MEDICINAL PRODUCT
DE3151912A1 (en) * 1981-12-23 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen NEW ERGOLIN AMINO DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS

Also Published As

Publication number Publication date
CS248738B2 (en) 1987-02-12
DE3413659A1 (en) 1985-10-17
ES542069A0 (en) 1985-12-16

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