ES8601967A1 - Un procedimiento de preparar sales quinato de alfa-2-piperi-dinil-2,8-bis(trifluorometil)-4-quinolino-metanol - Google Patents
Un procedimiento de preparar sales quinato de alfa-2-piperi-dinil-2,8-bis(trifluorometil)-4-quinolino-metanolInfo
- Publication number
- ES8601967A1 ES8601967A1 ES540693A ES540693A ES8601967A1 ES 8601967 A1 ES8601967 A1 ES 8601967A1 ES 540693 A ES540693 A ES 540693A ES 540693 A ES540693 A ES 540693A ES 8601967 A1 ES8601967 A1 ES 8601967A1
- Authority
- ES
- Spain
- Prior art keywords
- mefloquine
- antimalarial compound
- quinate
- salts
- quinate salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C62/02—Saturated compounds containing hydroxy or O-metal groups
- C07C62/04—Saturated compounds containing hydroxy or O-metal groups with a six-membered ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Tropical Medicine & Parasitology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE SALES QUINATO DE A-2-PIPERIDINIL-2,8-BIS(TRIFLUOROMETIL)-4-QUINOLEINMETANOL, DE FORMULA (I), EN LA QUE N VALE 1 O 2. CONSISTE EN LA REACCION DE ACIDO QUIMICO CON UN COMPUESTO DE FORMULA (II), EN LA PROPORCION DE UN MOL DE ACIDO QUIMICO POR 1 MOL O 2 MOLES DE COMPUESTO DE FORMULA (II). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO INERTE, TAL COMO UN ALCOHOL INFERIOR O UNA AMIDA A UNA TEMPERATURA COMPRENDIDA ENTRE LA AMBIENTE Y 100C. DESPUES DE SEPARAR POR FILTRACION EL PRODUCTO FORMADO, EL FILTRADO SE CONCENTRA A 100C A PRESION REDUCIDA Y DESPUES DE ELIMINAR EL DISOLVENTE SE SECA EL PRODUCTO SOLIDO. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTIMALARICA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/584,183 US4521424A (en) | 1984-02-27 | 1984-02-27 | Quinate salts of the antimalarial compound mefloquine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES540693A0 ES540693A0 (es) | 1985-11-16 |
| ES8601967A1 true ES8601967A1 (es) | 1985-11-16 |
Family
ID=24336239
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES540693A Expired ES8601967A1 (es) | 1984-02-27 | 1985-02-26 | Un procedimiento de preparar sales quinato de alfa-2-piperi-dinil-2,8-bis(trifluorometil)-4-quinolino-metanol |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US4521424A (es) |
| EP (1) | EP0154491B1 (es) |
| JP (1) | JPS60202880A (es) |
| KR (1) | KR850006405A (es) |
| AT (1) | ATE51227T1 (es) |
| AU (1) | AU577570B2 (es) |
| DE (1) | DE3576687D1 (es) |
| DK (1) | DK84785A (es) |
| ES (1) | ES8601967A1 (es) |
| GR (1) | GR850484B (es) |
| JO (1) | JO1358B1 (es) |
| PH (1) | PH22441A (es) |
| PT (1) | PT80013B (es) |
| ZA (1) | ZA851429B (es) |
| ZW (1) | ZW2885A1 (es) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2748333A1 (de) * | 1977-10-28 | 1979-05-03 | Hoechst Ag | Mittel gegen malaria |
-
1984
- 1984-02-27 US US06/584,183 patent/US4521424A/en not_active Expired - Fee Related
-
1985
- 1985-02-25 JO JO19851358A patent/JO1358B1/en active
- 1985-02-25 DK DK84785A patent/DK84785A/da not_active Application Discontinuation
- 1985-02-25 ZW ZW28/85A patent/ZW2885A1/xx unknown
- 1985-02-26 JP JP60038606A patent/JPS60202880A/ja active Pending
- 1985-02-26 DE DE8585301279T patent/DE3576687D1/de not_active Expired - Fee Related
- 1985-02-26 PT PT80013A patent/PT80013B/pt unknown
- 1985-02-26 ZA ZA851429A patent/ZA851429B/xx unknown
- 1985-02-26 GR GR850484A patent/GR850484B/el unknown
- 1985-02-26 EP EP85301279A patent/EP0154491B1/en not_active Expired - Lifetime
- 1985-02-26 AT AT85301279T patent/ATE51227T1/de not_active IP Right Cessation
- 1985-02-26 ES ES540693A patent/ES8601967A1/es not_active Expired
- 1985-02-27 AU AU39212/85A patent/AU577570B2/en not_active Ceased
- 1985-02-27 KR KR1019850001214A patent/KR850006405A/ko not_active Application Discontinuation
- 1985-02-27 PH PH31919A patent/PH22441A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0154491A3 (en) | 1986-07-30 |
| DK84785D0 (da) | 1985-02-25 |
| PT80013B (en) | 1987-01-14 |
| DE3576687D1 (de) | 1990-04-26 |
| AU3921285A (en) | 1985-09-05 |
| KR850006405A (ko) | 1985-10-05 |
| GR850484B (es) | 1985-06-26 |
| ZA851429B (en) | 1985-10-30 |
| PH22441A (en) | 1988-09-12 |
| JO1358B1 (en) | 1986-11-30 |
| EP0154491B1 (en) | 1990-03-21 |
| JPS60202880A (ja) | 1985-10-14 |
| ES540693A0 (es) | 1985-11-16 |
| ZW2885A1 (en) | 1985-05-22 |
| US4521424A (en) | 1985-06-04 |
| PT80013A (en) | 1985-03-01 |
| AU577570B2 (en) | 1988-09-29 |
| DK84785A (da) | 1985-08-28 |
| EP0154491A2 (en) | 1985-09-11 |
| ATE51227T1 (de) | 1990-04-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT83647A (en) | Process for the preparation of novel pharmaceutical benzimidazole derivatives and of pharmaceutical compositions containing the same | |
| IL84917A0 (en) | Quinolinone derivative,its preparation and pharmaceutical compositions containing it | |
| IL92358A0 (en) | Diaryl compounds,their preparation and pharmaceutical compositions containing them | |
| SE8404065D0 (sv) | Novel biologically active compounds | |
| AU584235B2 (en) | New tricyclic compounds, processes for the preparation thereof and pharmaceutical compositions containing them | |
| SE8405588D0 (sv) | New compounds | |
| EP0270046A3 (en) | Pharmaceutical composition for treatment of cataract | |
| ES2000681A6 (es) | Un procedimiento para preparar nuevos compuestos de bencilpiperazina | |
| ES8601967A1 (es) | Un procedimiento de preparar sales quinato de alfa-2-piperi-dinil-2,8-bis(trifluorometil)-4-quinolino-metanol | |
| IL74755A (en) | Quinate salts of the antimalarial compound mefloquine,process for their preparation and pharmaceutical compositions comprising them | |
| ES8606375A1 (es) | Un procedimiento para preparar un derivado de aminoprpilaminobleomicina |