ES8601953A1 - Un procedimiento para preparar acido 19-(3,6-dihidro-3-metil-6-oxo-2h-piran-2-il-)-17-etil-6-hidroxi-9-(hidroximetil)-3,5,7,11,15-pentametil-8-oxo-2,10,12,16,18,-nonadecapentaenoico. - Google Patents

Un procedimiento para preparar acido 19-(3,6-dihidro-3-metil-6-oxo-2h-piran-2-il-)-17-etil-6-hidroxi-9-(hidroximetil)-3,5,7,11,15-pentametil-8-oxo-2,10,12,16,18,-nonadecapentaenoico.

Info

Publication number
ES8601953A1
ES8601953A1 ES535810A ES535810A ES8601953A1 ES 8601953 A1 ES8601953 A1 ES 8601953A1 ES 535810 A ES535810 A ES 535810A ES 535810 A ES535810 A ES 535810A ES 8601953 A1 ES8601953 A1 ES 8601953A1
Authority
ES
Spain
Prior art keywords
new
oxo
salts
production
configuration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES535810A
Other languages
English (en)
Other versions
ES535810A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of ES8601953A1 publication Critical patent/ES8601953A1/es
Publication of ES535810A0 publication Critical patent/ES535810A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/20—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hydrogen atoms and substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D309/22—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE ACIDO 19-(3,6-DIHIDRO-3-METIL-6-OXO-2H-PIRAN-2-IL)-17-ETIL-6-HIDROXI-9-(HIDROXIMETIL)-3,5,7,11,15-PENTAMETIL-8-OXO-2,10,12,16,18-NONADECAPENTAENOICO, DE FORMULA (I), Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES. COMPRENDE EL CULTIVO DE UNA CEPA DE UN ACTINOMICETO, IDENTIFICADO COMO AISLADO ATCC 39366, EN CONDICIONES AEROBIAS, EN UN MEDIO DE CULTIVO QUE CONTIENE FUENTES ASIMILABLES DE CARBONO Y NITROGENO, ASI COMO MINERALES Y FACTORES DE CRECIMIENTO; SEGUIDO DE LA SEPARACION Y PURIFICACION DEL COMPUESTO OBTENIDO SIGUIENDO METODOS CONVENCIONALES. ESTE COMPUESTO TIENE APLICACIONES FARMACOLOGICAS, TANTO POR SU ACTIVIDAD MICROBIANA COMO ANTITUMORAL.
ES535810A 1983-09-12 1984-09-11 Un procedimiento para preparar acido 19-(3,6-dihidro-3-metil-6-oxo-2h-piran-2-il-)-17-etil-6-hidroxi-9-(hidroximetil)-3,5,7,11,15-pentametil-8-oxo-2,10,12,16,18,-nonadecapentaenoico. Granted ES535810A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US53112883A 1983-09-12 1983-09-12

Publications (2)

Publication Number Publication Date
ES8601953A1 true ES8601953A1 (es) 1985-11-01
ES535810A0 ES535810A0 (es) 1985-11-01

Family

ID=24116352

Family Applications (1)

Application Number Title Priority Date Filing Date
ES535810A Granted ES535810A0 (es) 1983-09-12 1984-09-11 Un procedimiento para preparar acido 19-(3,6-dihidro-3-metil-6-oxo-2h-piran-2-il-)-17-etil-6-hidroxi-9-(hidroximetil)-3,5,7,11,15-pentametil-8-oxo-2,10,12,16,18,-nonadecapentaenoico.

Country Status (7)

Country Link
EP (1) EP0139457A3 (es)
JP (1) JPS60120874A (es)
AU (1) AU572878B2 (es)
CA (1) CA1232852A (es)
DK (1) DK431284A (es)
ES (1) ES535810A0 (es)
GR (1) GR80315B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU574713B2 (en) * 1983-09-12 1988-07-14 Warner-Lambert Company Cl-1957a antibiotic compound and its production
JPS60141293A (ja) * 1983-12-28 1985-07-26 Kitasato Inst:The 新規制癌性抗生物質８１−４８４およびその製造法
US4952709A (en) * 1989-07-12 1990-08-28 Bristol Myers Company Antitumor antibiotic BU-3285T compounds
JPH04354545A (ja) * 1991-05-29 1992-12-08 Hajime Tomokage 循環式小型クリーンルーム
JP4480128B2 (ja) * 2002-11-20 2010-06-16 独立行政法人科学技術振興機構 マトリックスメタロプロテアーゼ−９の産生を阻害するための薬剤

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE54287B1 (en) * 1982-02-24 1989-08-16 Warner Lambert Co Cl 1565 antibiotic compounds and their production
GB2119787B (en) * 1982-04-07 1985-07-10 Ss Pharmaceutical Co Pyrones
EP0128651A3 (en) * 1983-05-12 1987-01-07 Warner-Lambert Company Pyranones and related compounds and methods for their production and use
AU574713B2 (en) * 1983-09-12 1988-07-14 Warner-Lambert Company Cl-1957a antibiotic compound and its production

Also Published As

Publication number Publication date
DK431284D0 (da) 1984-09-10
JPS60120874A (ja) 1985-06-28
GR80315B (en) 1985-01-08
AU572878B2 (en) 1988-05-19
AU3203984A (en) 1985-03-21
CA1232852A (en) 1988-02-16
ES535810A0 (es) 1985-11-01
DK431284A (da) 1985-03-13
EP0139457A2 (en) 1985-05-02
EP0139457A3 (en) 1987-03-25

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