ES8601951A1 - Un procedimiento para la preparacion de nuevos cinamil-2,3-dihidro-benzofuranos sustituidos y sus analagos. - Google Patents
Un procedimiento para la preparacion de nuevos cinamil-2,3-dihidro-benzofuranos sustituidos y sus analagos.Info
- Publication number
- ES8601951A1 ES8601951A1 ES536683A ES536683A ES8601951A1 ES 8601951 A1 ES8601951 A1 ES 8601951A1 ES 536683 A ES536683 A ES 536683A ES 536683 A ES536683 A ES 536683A ES 8601951 A1 ES8601951 A1 ES 8601951A1
- Authority
- ES
- Spain
- Prior art keywords
- substituted
- cinnamylphenols
- dihydrobenzopyrans
- useful
- inflammatory agents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
- C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
- C07C49/24—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups
- C07C49/245—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings
- C07C49/248—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings having unsaturation outside the aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
- C07C49/835—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups having unsaturation outside an aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Pain & Pain Management (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/541,200 US4537903A (en) | 1983-10-12 | 1983-10-12 | Substituted cinnamyl-2,3-dihydrobenzofuran and analogs useful as anti-inflammatory agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES536683A0 ES536683A0 (es) | 1985-11-16 |
| ES8601951A1 true ES8601951A1 (es) | 1985-11-16 |
Family
ID=24158589
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES536683A Expired ES8601951A1 (es) | 1983-10-12 | 1984-10-11 | Un procedimiento para la preparacion de nuevos cinamil-2,3-dihidro-benzofuranos sustituidos y sus analagos. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4537903A (enExample) |
| EP (1) | EP0143952B1 (enExample) |
| JP (1) | JPS6097924A (enExample) |
| CA (1) | CA1258855A (enExample) |
| DE (1) | DE3486034T2 (enExample) |
| DK (1) | DK486284A (enExample) |
| ES (1) | ES8601951A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4733002A (en) * | 1984-05-23 | 1988-03-22 | Green Cross Corporation | Lipoxygenase inhibitor |
| US4713393A (en) * | 1985-04-25 | 1987-12-15 | Merck & Co., Inc. | Phenylpropyl-2,3-dihydrobenzofurans useful as anti-inflammatory agents |
| EP0270690B1 (en) * | 1986-06-21 | 1991-05-15 | Dainippon Ink And Chemicals, Inc. | Drug for treatment and prophylaxis of kidney and liver diseases |
| IT1229482B (it) * | 1988-08-01 | 1991-09-03 | Foscama Biomed Chim Farma | Acidi (rs) 2 (2,3 diidro 5 idrossi 4,6,7 trimetilbenzofuranil) acetico e 2 (2,3 diidro 5 acilossi 4,6,7 trimetilbenzofuranil) acetici e loro esteri, utili come farmaci mucoregolatori ed antiischemici. |
| US4966907A (en) * | 1988-08-12 | 1990-10-30 | Merck & Co., Inc. | 6-substituted 5-hydroxy-2,3-dihydrobenzofurans as inhibitors of leukotriene biosynthesis |
| US5272156A (en) * | 1989-09-19 | 1993-12-21 | Allergan, Inc. | Acetylenes disubstituted with a heteroaromatic group and a 2-substituted 1,2,3,4-tetrahydroquinolinyl group having retinoid-like activity |
| US4975457A (en) * | 1989-09-25 | 1990-12-04 | Merck & Co., Inc. | Trans 2,3-disubstituted-2,3-dihydro-5-hydroxy-benzofurans as inhibitors of leukotriene biosynthesis |
| US5091533A (en) * | 1990-03-12 | 1992-02-25 | Merck Frosst Canada, Inc. | 5-hydroxy-2,3-dihydrobenzofuran analogs as leukotriene biosynthesis inhibitors |
| US5118707A (en) * | 1990-10-31 | 1992-06-02 | The Procter & Gamble Company | Compositions for regulating skin wrinkles comprising a benzofuran derivative |
| CA2450073C (en) | 2001-07-25 | 2017-08-29 | Biomarin Pharmaceutical Inc. | Compositions and methods for modulating blood-brain barrier transport |
| EP2671508B1 (en) | 2005-04-28 | 2020-09-16 | Proteus Digital Health, Inc. | Pharma-informatics system |
| JP2010503710A (ja) | 2006-09-18 | 2010-02-04 | ラプトール ファーマシューティカル インコーポレイテッド | 受容体関連タンパク質（ｒａｐ）結合体の投与による肝障害の処置 |
| ES2919563T3 (es) | 2009-02-20 | 2022-07-27 | Enhanx Biopharm Inc | Sistema de administración de medicamentos a base de glutatión |
| KR20180114970A (ko) | 2009-05-06 | 2018-10-19 | 라보라토리 스킨 케어, 인크. | 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법 |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
| US11512034B2 (en) | 2020-05-29 | 2022-11-29 | Mcmaster University | Processes for the preparation of ortho-allylated hydroxy aryl compounds |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3865748A (en) * | 1970-09-22 | 1975-02-11 | Us Agriculture | Cinnamyl phenol antimicrobial agents |
| US3745222A (en) * | 1970-09-22 | 1973-07-10 | Us Agriculture | Cinnamyl phenols useful as antimicrobial agents |
| DE2720321A1 (de) * | 1976-05-17 | 1977-12-01 | Sandoz Ag | Neue benzofuran- und benzoxepinderivate |
| US4105698A (en) * | 1977-02-16 | 1978-08-08 | Continental Oil Company | Preparation of cinnamyl-substituted phenols |
| JPS5829782A (ja) * | 1981-08-12 | 1983-02-22 | Nippon Zoki Pharmaceut Co Ltd | 新規複素環化合物、その製法及び該化合物を含有する医薬組成物 |
-
1983
- 1983-10-12 US US06/541,200 patent/US4537903A/en not_active Expired - Fee Related
-
1984
- 1984-10-10 CA CA000465057A patent/CA1258855A/en not_active Expired
- 1984-10-11 ES ES536683A patent/ES8601951A1/es not_active Expired
- 1984-10-11 EP EP84112187A patent/EP0143952B1/en not_active Expired - Lifetime
- 1984-10-11 DK DK486284A patent/DK486284A/da not_active Application Discontinuation
- 1984-10-11 JP JP59211562A patent/JPS6097924A/ja active Granted
- 1984-10-11 DE DE8484112187T patent/DE3486034T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE3486034T2 (de) | 1993-08-05 |
| EP0143952A1 (en) | 1985-06-12 |
| ES536683A0 (es) | 1985-11-16 |
| EP0143952B1 (en) | 1993-01-13 |
| US4537903A (en) | 1985-08-27 |
| DK486284D0 (da) | 1984-10-11 |
| CA1258855A (en) | 1989-08-29 |
| JPH0510347B2 (enExample) | 1993-02-09 |
| DK486284A (da) | 1985-05-14 |
| DE3486034D1 (de) | 1993-02-25 |
| JPS6097924A (ja) | 1985-05-31 |
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