ES8600636A1 - Piperazine derivatives - Google Patents

Piperazine derivatives

Info

Publication number
ES8600636A1
ES8600636A1 ES535909A ES535909A ES8600636A1 ES 8600636 A1 ES8600636 A1 ES 8600636A1 ES 535909 A ES535909 A ES 535909A ES 535909 A ES535909 A ES 535909A ES 8600636 A1 ES8600636 A1 ES 8600636A1
Authority
ES
Spain
Prior art keywords
denotes
group
lower alkyl
alkyl group
piperazine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES535909A
Other languages
Spanish (es)
Other versions
ES535909A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fordonal SA
Original Assignee
Fordonal SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB838304528A external-priority patent/GB8304528D0/en
Application filed by Fordonal SA filed Critical Fordonal SA
Publication of ES8600636A1 publication Critical patent/ES8600636A1/en
Publication of ES535909A0 publication Critical patent/ES535909A0/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Piperazine derivatives of the formula < IMAGE > in which R<1> denotes a cycloalkyl or cycloalkenyl group, where each such group contains 5 or 6 carbon atoms, or denotes a thienyl group or denotes a phenyl group, optionally substituted by a halogen atom or a trifluoromethyl or lower alkyl group, R<2> denotes a hydrogen or halogen atom or a trifluoromethyl or lower alkyl group, R<3> denotes a hydrogen or halogen atom or a lower alkyl group or a cycloalkyl group having 5 or 6 carbon atoms and R<4> denotes a hydrogen atom or a lower alkyl group, are novel compounds, which have been found to have useful pharmacological properties, in particular vasodilatory and antihistamine activity. Various methods for the preparation of the piperazine derivatives and suitable pharmaceutical compositions containing them are described.
ES535909A 1982-05-25 1984-09-14 PIPERACINE DERIVATIVES PREPARATION PROCEDURE Granted ES535909A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8215219 1982-05-25
GB838304528A GB8304528D0 (en) 1983-02-18 1983-02-18 Piperazine derivatives

Publications (2)

Publication Number Publication Date
ES8600636A1 true ES8600636A1 (en) 1985-10-16
ES535909A0 ES535909A0 (en) 1985-10-16

Family

ID=26282941

Family Applications (6)

Application Number Title Priority Date Filing Date
ES522651A Granted ES522651A0 (en) 1982-05-25 1983-05-24 PIPERACINE DERIVATIVES PREPARATION PROCEDURE
ES522652A Granted ES522652A0 (en) 1982-05-25 1983-05-24 PROCEDURE FOR THE PREPARATION OF PIPERACINE DERIVATIVES.
ES522650A Expired ES8406456A1 (en) 1982-05-25 1983-05-24 Piperazine derivatives
ES522653A Expired ES8407318A1 (en) 1982-05-25 1983-05-24 Piperazine derivatives
ES535909A Granted ES535909A0 (en) 1982-05-25 1984-09-14 PIPERACINE DERIVATIVES PREPARATION PROCEDURE
ES535910A Expired ES8600637A1 (en) 1982-05-25 1984-09-14 Piperazine derivatives

Family Applications Before (4)

Application Number Title Priority Date Filing Date
ES522651A Granted ES522651A0 (en) 1982-05-25 1983-05-24 PIPERACINE DERIVATIVES PREPARATION PROCEDURE
ES522652A Granted ES522652A0 (en) 1982-05-25 1983-05-24 PROCEDURE FOR THE PREPARATION OF PIPERACINE DERIVATIVES.
ES522650A Expired ES8406456A1 (en) 1982-05-25 1983-05-24 Piperazine derivatives
ES522653A Expired ES8407318A1 (en) 1982-05-25 1983-05-24 Piperazine derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES535910A Expired ES8600637A1 (en) 1982-05-25 1984-09-14 Piperazine derivatives

Country Status (4)

Country Link
DE (1) DE3318577A1 (en)
ES (6) ES522651A0 (en)
FR (1) FR2527605A1 (en)
IT (1) IT1169416B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES529395A0 (en) * 1984-01-17 1985-08-01 Ferrer Int IMPROVEMENTS IN THE PURPOSE OF INVENTION PATENT N 514,340 THAT REFERS TO: PROCEDURE FOR OBTAINING NEW DERIVATIVES OF PIPERAZINE
ITMI20021327A1 (en) * 2002-06-14 2003-12-15 Recordati Chem Pharm NEW OSSIALCHILPIPERAZINE
US7071197B2 (en) 2002-06-14 2006-07-04 Recordati S.A. N,N-disubstituted diazocycloalkanes
CN1326845C (en) * 2003-11-05 2007-07-18 河北医科大学 Process for preparing bis-phenyl fluorozine and its use as medicine in treatment of cardiovascular and cerebrovascular diseases

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2997474A (en) * 1959-10-12 1961-08-22 Paul A J Janssen 1-aryl-omega-(4-arylpiperazine) alkanols
FR1485246A (en) * 1966-06-30 1967-06-16 Science Union & Cie Novel piperonyl-piperazine derivatives and their preparation process
BE758380A (en) * 1969-11-04 1971-04-16 Sumitomo Chemical Co PROCESS FOR PREPARATION OF ARYL-KETON DERIVATIVES
FR2081579B1 (en) * 1970-03-18 1973-04-06 Delalande Sa

Also Published As

Publication number Publication date
DE3318577A1 (en) 1983-12-01
ES8502981A1 (en) 1985-02-01
ES8406457A1 (en) 1984-08-01
IT8321230A0 (en) 1983-05-23
ES522650A0 (en) 1984-08-01
ES522653A0 (en) 1984-09-16
FR2527605A1 (en) 1983-12-02
ES522652A0 (en) 1985-02-01
ES8407318A1 (en) 1984-09-16
ES535910A0 (en) 1985-10-16
ES8600637A1 (en) 1985-10-16
ES522651A0 (en) 1984-08-01
ES8406456A1 (en) 1984-08-01
ES535909A0 (en) 1985-10-16
IT1169416B (en) 1987-05-27

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