ES8507146A1 - Un procedimiento para la preparacion de compuestos de -lactama - Google Patents

Un procedimiento para la preparacion de compuestos de -lactama

Info

Publication number
ES8507146A1
ES8507146A1 ES537350A ES537350A ES8507146A1 ES 8507146 A1 ES8507146 A1 ES 8507146A1 ES 537350 A ES537350 A ES 537350A ES 537350 A ES537350 A ES 537350A ES 8507146 A1 ES8507146 A1 ES 8507146A1
Authority
ES
Spain
Prior art keywords
group
hydrogen
precursors
yes
penem derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES537350A
Other languages
English (en)
Other versions
ES537350A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB838305704A external-priority patent/GB8305704D0/en
Priority claimed from GB838330516A external-priority patent/GB8330516D0/en
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES8507146A1 publication Critical patent/ES8507146A1/es
Publication of ES537350A0 publication Critical patent/ES537350A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568—Four-membered rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE COMPUESTOS DE BBB-LACTAMA.CONSISTE EN HACER REACCIONAR UN SULFOXIDO DE FORMULA (II) CON UN TIOL DE FORMULA (RA-SH), EN ACETONITRILO, N,N-DIMETILFORMAMIDA A UNA TEMPERATURA ENTRE C30JC Y C70JC Y SEPARAR DE CUALQUIER GRUPO RX DE BLOQUEO, EL CARBOXILO, PARA OBTENER UN PRODUCTO DE FORMULA (I) Y SUS SALES FARMACEUTICAMENTE ACEPTABLES Y ESTERES HIDROLIZABLES IN VIVO DE LOS MISMOS, SIENDO; R1 Y R2, H; RX UN GRUPO DE FORMULA (III); R3, H O UN GRUPO ORGANICO; R4 UN GRUPO SUSTITUYENTE; R18 UN GRUPO ORGANICO DIFERENTE DE RA; RA UN HIDROCARBILO DE C 1 A 10; X, O, S O -NR5; R5, H, HIDROCARBILO Y OTROS Y N, 0, 1, 2 O 3.SE UTILIZAN PARA EL TRATAMIENTO DE LAS INFECCIONES EN MAMIFEROS.
ES537350A 1983-03-02 1984-11-02 Un procedimiento para la preparacion de compuestos de -lactama Granted ES537350A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB838305704A GB8305704D0 (en) 1983-03-02 1983-03-02 Beta-lactam compounds
GB838330516A GB8330516D0 (en) 1983-11-16 1983-11-16 Compounds

Publications (2)

Publication Number Publication Date
ES8507146A1 true ES8507146A1 (es) 1985-08-16
ES537350A0 ES537350A0 (es) 1985-08-16

Family

ID=26285399

Family Applications (3)

Application Number Title Priority Date Filing Date
ES530153A Expired ES8605810A1 (es) 1983-03-02 1984-02-29 Un procedimiento para la preparacion de compuestos de beta-lactama
ES537351A Granted ES537351A0 (es) 1983-03-02 1984-11-02 Un procedimiento para la preparacion de compuestos de -lactama
ES537350A Granted ES537350A0 (es) 1983-03-02 1984-11-02 Un procedimiento para la preparacion de compuestos de -lactama

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES530153A Expired ES8605810A1 (es) 1983-03-02 1984-02-29 Un procedimiento para la preparacion de compuestos de beta-lactama
ES537351A Granted ES537351A0 (es) 1983-03-02 1984-11-02 Un procedimiento para la preparacion de compuestos de -lactama

Country Status (5)

Country Link
EP (1) EP0120613A1 (es)
AU (1) AU568119B2 (es)
ES (3) ES8605810A1 (es)
GR (1) GR79528B (es)
NZ (1) NZ207315A (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI82471C (fi) * 1984-01-26 1991-03-11 Beecham Group Plc Foerfarande foer framstaellning av farmakologiskt aktiva 6-metylenpenemderivater.
GB8518416D0 (en) * 1985-07-22 1985-08-29 Beecham Group Plc Compounds
GB8518422D0 (en) * 1985-07-22 1985-08-29 Beecham Group Plc Compounds
DE3618813A1 (de) * 1986-06-04 1987-12-10 Hoechst Ag Pharmazeutische zubereitung zur behandlung bakterieller infektionen
GB8711391D0 (en) * 1987-05-14 1987-06-17 Beecham Group Plc Process
CA2105746A1 (en) * 1992-09-09 1994-03-10 Akira Yoshida Process for preparing carbapenem and penem compounds and new compounds involved in that process
US6472383B1 (en) 1994-04-25 2002-10-29 Smithkline Beecham P.L.C. Pharmaceutical formulations
CN1094353C (zh) * 1994-04-25 2002-11-20 史密斯克莱·比奇曼公司 含有β－内酰胺酶抑制性青霉烯与β－内酰胺抗生素复合的药物制剂及其在治疗细菌感染中的应用
US5629306A (en) * 1994-12-09 1997-05-13 Research Corporation Technologies, Inc. 7-alkylidene cephalosporanic acid derivatives and methods of using the same
US6407091B1 (en) 1999-04-15 2002-06-18 Research Corporation Technologies, Inc. β-lactamase inhibiting compounds
AR039774A1 (es) 2002-05-01 2005-03-02 Wyeth Corp 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas
AR039475A1 (es) 2002-05-01 2005-02-23 Wyeth Corp 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa
EP2167081B1 (en) 2007-05-21 2013-06-26 Hans Rudolf Pfaendler Bactericidal anti-mrsa active pharmaceutical composition containing carbapenems

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3176517D1 (en) * 1980-04-24 1987-12-17 Beecham Group Plc Beta-lactam compounds, their preparation and use
CA1180005A (en) * 1980-10-24 1984-12-27 Solange Adam-Molina .beta.-LACTAMS

Also Published As

Publication number Publication date
ES8603404A1 (es) 1985-12-16
ES537351A0 (es) 1985-12-16
GR79528B (es) 1984-10-30
AU2518984A (en) 1984-09-06
ES530153A0 (es) 1986-04-01
NZ207315A (en) 1987-07-31
AU568119B2 (en) 1987-12-17
EP0120613A1 (en) 1984-10-03
ES8605810A1 (es) 1986-04-01
ES537350A0 (es) 1985-08-16

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