ES8506766A1 - Un procedimiento para la preparacion de un producto polimerico con afinidad selectiva para la trombina. - Google Patents

Un procedimiento para la preparacion de un producto polimerico con afinidad selectiva para la trombina.

Info

Publication number
ES8506766A1
ES8506766A1 ES533789A ES533789A ES8506766A1 ES 8506766 A1 ES8506766 A1 ES 8506766A1 ES 533789 A ES533789 A ES 533789A ES 533789 A ES533789 A ES 533789A ES 8506766 A1 ES8506766 A1 ES 8506766A1
Authority
ES
Spain
Prior art keywords
thrombine
copolymer
vis
polymer
purification
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES533789A
Other languages
English (en)
Other versions
ES533789A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Commissariat a lEnergie Atomique et aux Energies Alternatives CEA
Original Assignee
Commissariat a lEnergie Atomique CEA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Commissariat a lEnergie Atomique CEA filed Critical Commissariat a lEnergie Atomique CEA
Publication of ES533789A0 publication Critical patent/ES533789A0/es
Publication of ES8506766A1 publication Critical patent/ES8506766A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/795—Polymers containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0076—Chemical modification of the substrate
    • A61L33/0082—Chemical modification of the substrate by reacting with an organic compound other than heparin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06—Use of macromolecular materials
    • A61L33/064—Use of macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/30—Introducing nitrogen atoms or nitrogen-containing groups
    • C08F8/32—Introducing nitrogen atoms or nitrogen-containing groups by reaction with amines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6429—Thrombin (3.4.21.5)
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2810/00—Chemical modification of a polymer
    • C08F2810/20—Chemical modification of a polymer leading to a crosslinking, either explicitly or inherently

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Surgery (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials Engineering (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Polymers & Plastics (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • External Artificial Organs (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE UN PRODUCTO POLIMERICO CON AFINIDAD SELECTIVA PARA LA TROMBINA, EL CUAL ESTA CONSTITUIDO POR UN POLIMERO O UN COPOLIMERO QUE COMPRENDE EN SU CADENA GRUPOS SUSTITUIBLES SOBRE LOS CUALES ESJTAN FIJADOS DE MODO ESTADISTICO, GRUPOS X E Y.CONSISTE EN CLOROSULFONAR UN POLIMERO O UN COPOLIMERO HACIENDOLO REACCIONAR CON ACIDO CLOROSULFONICO, Y EN TRANSFORMAR LOS GRUPOS -SO2CL, FIJADOS SOBRE EL POLIMERO O EL COPOLIMERO, EN GRUPOS -SO3R1 O -SO2R2, MEDIANTE LA REACCION DEL POLIMERO O DEL COPOLIMERO CLOROSULFONADO CON LA ARGININA O CON UN DERIVADO DE LA ARGININA EN MEDIO BASICO.DE APLICACION EN LA SEPARACION Y PURIFICACION DE LA TROMBINA.
ES533789A 1983-06-29 1984-06-28 Un procedimiento para la preparacion de un producto polimerico con afinidad selectiva para la trombina. Expired ES8506766A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8310773A FR2548193B1 (fr) 1983-06-29 1983-06-29 Produit constitue par un polymere ou un copolymere comportant dans sa chaine des groupes presentant une affinite vis-a-vis de la thrombine, son procede de preparation et son utilisation pour la separation et la purification de la thrombine

Publications (2)

Publication Number Publication Date
ES533789A0 ES533789A0 (es) 1985-08-01
ES8506766A1 true ES8506766A1 (es) 1985-08-01

Family

ID=9290302

Family Applications (1)

Application Number Title Priority Date Filing Date
ES533789A Expired ES8506766A1 (es) 1983-06-29 1984-06-28 Un procedimiento para la preparacion de un producto polimerico con afinidad selectiva para la trombina.

Country Status (8)

Country Link
US (1) US4568725A (es)
EP (1) EP0130898B1 (es)
JP (1) JPS6036505A (es)
AT (1) ATE29891T1 (es)
CA (1) CA1243309A (es)
DE (1) DE3466399D1 (es)
ES (1) ES8506766A1 (es)
FR (1) FR2548193B1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57210068A (en) * 1981-06-17 1982-12-23 Asahi Chemical Ind Production of polyurethane fiber having anti-fungal property
FR2582815B1 (fr) * 1985-05-31 1989-04-07 Commissariat Energie Atomique Procede de separation des anticorps antifacteur viii : c, utilisable notamment pour l'epuration du plasma sanguin d'un hemophile de type a
FR2635019B1 (fr) * 1988-08-02 1992-06-12 Centre Nat Rech Scient Materiau capable de fixer les substances biologiques, et ses applications notamment comme support de chromatographie d'affinite
US5116994A (en) * 1989-04-19 1992-05-26 Fuji Photo Film Co., Ltd. Deacylating agent and deacylating method
ATE221546T1 (de) * 1997-03-01 2002-08-15 Vestolit Gmbh & Co Kg Formmassen mit antikoagulierenden eigenschaften, ihre herstellung und verarbeitung zu gegenständen,die in der medizintechnik verwendungen finden
DE19908525C2 (de) * 1999-02-26 2001-05-31 Inst Chemo Biosensorik Wasserlösliches Copolymer und Verwendung hiervon
FR2816621A1 (fr) * 2000-11-13 2002-05-17 Bioracs Resines de polystyrene fonctionnalise par des groupements methyl ester de la l-tyrosine et leurs applications
US20090038701A1 (en) 2006-01-17 2009-02-12 Baxter International Inc. Device, system and method for mixing
EP2213245B1 (en) * 2006-01-17 2012-07-04 Baxter International Inc. Device and method for mixing
US20100246316A1 (en) * 2009-03-31 2010-09-30 Baxter International Inc. Dispenser, kit and mixing adapter
US8641661B2 (en) * 2010-01-05 2014-02-04 Baxter International Inc. Mixing system, kit and mixer adapter
CA2726566A1 (en) * 2010-01-11 2011-07-11 Baxter International Inc. Pipette system, pipette tip assembly and kit
EP3415153A1 (en) * 2012-01-30 2018-12-19 Baxalta GmbH Non-anticoagulant sulfated or sulfonated polysaccharides
JP6138829B2 (ja) * 2012-01-30 2017-05-31 バクスアルタ ゲーエムベーハー 非抗凝固性の硫酸化またはスルホン酸化合成ポリマー

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2808405A (en) * 1955-03-11 1957-10-01 Ohio Commw Eng Co Acylated amino acid esters of dextran products and method of making same
US3301848A (en) * 1962-10-30 1967-01-31 Pillsbury Co Polysaccharides and methods for production thereof
BE757783A (fr) * 1969-10-25 1971-04-21 Stamicarbon Liaison chimique d'un acide amine a un support polymere
NL7001822A (es) * 1970-02-10 1971-08-12
IT1075599B (it) * 1977-04-27 1985-04-22 Ferruti Paolo Polimero comprendente blocchi poliamido-amminici atto a formare materiali eparinizzabili per la fabbricazione di manufatti antitrombogeni
FR2461724A1 (fr) * 1979-07-20 1981-02-06 Christine Fougnot Polymeres substitues par des groupes leur conferant des proprietes anti-coagulantes et leur procede de preparation, objets constitues par et/ou comprenant lesdits polymeres et leurs procedes de fabrication, application desdits objets en chirurgie et en medecine, et compositions pharmaceutiques contenant lesdits polymeres substitues

Also Published As

Publication number Publication date
JPS6036505A (ja) 1985-02-25
EP0130898A1 (fr) 1985-01-09
DE3466399D1 (en) 1987-10-29
US4568725A (en) 1986-02-04
EP0130898B1 (fr) 1987-09-23
CA1243309A (en) 1988-10-18
ES533789A0 (es) 1985-08-01
FR2548193B1 (fr) 1985-10-18
ATE29891T1 (de) 1987-10-15
FR2548193A1 (fr) 1985-01-04

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