ES8504664A1 - Benzylamine deriv. - Google Patents

Benzylamine deriv.

Info

Publication number
ES8504664A1
ES8504664A1 ES526526A ES526526A ES8504664A1 ES 8504664 A1 ES8504664 A1 ES 8504664A1 ES 526526 A ES526526 A ES 526526A ES 526526 A ES526526 A ES 526526A ES 8504664 A1 ES8504664 A1 ES 8504664A1
Authority
ES
Spain
Prior art keywords
formula
amino
reacting
give
deriv
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES526526A
Other languages
Spanish (es)
Other versions
ES526526A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sociedad Espanola de Especialidades Farmaco Terapeuticas SA
Original Assignee
Sociedad Espanola de Especialidades Farmaco Terapeuticas SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sociedad Espanola de Especialidades Farmaco Terapeuticas SA filed Critical Sociedad Espanola de Especialidades Farmaco Terapeuticas SA
Priority to ES526526A priority Critical patent/ES8504664A1/en
Publication of ES526526A0 publication Critical patent/ES526526A0/en
Publication of ES8504664A1 publication Critical patent/ES8504664A1/en
Expired legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Trans-4-hydroxy N-(2-amino 3,5-dibromo benzyl) cyclohexylamine of formula (I) is made by (a) reacting a 2-amino benzoate ester of formula (II) with bromine; (b) reducing the prod. with a metal hydride complex to give 2-amino 3,5-dibromo benzyl alcohol; (c) reacting this with a halogenating agent to form 2-amino 3,5-dibromo benzyl halide; (d) reacting this with a cpd. of formula (III) to give a cpd. of formula (IV) which is (e) hydrolysed in aq. acid medium to give (I).
ES526526A 1983-10-17 1983-10-17 Benzylamine deriv. Expired ES8504664A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES526526A ES8504664A1 (en) 1983-10-17 1983-10-17 Benzylamine deriv.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES526526A ES8504664A1 (en) 1983-10-17 1983-10-17 Benzylamine deriv.

Publications (2)

Publication Number Publication Date
ES526526A0 ES526526A0 (en) 1985-04-16
ES8504664A1 true ES8504664A1 (en) 1985-04-16

Family

ID=8486332

Family Applications (1)

Application Number Title Priority Date Filing Date
ES526526A Expired ES8504664A1 (en) 1983-10-17 1983-10-17 Benzylamine deriv.

Country Status (1)

Country Link
ES (1) ES8504664A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103012167A (en) * 2012-12-16 2013-04-03 石药集团中诺药业（石家庄）有限公司 Preparation method of ambroxol hydrochloride
CN112142604A (en) * 2020-10-28 2020-12-29 河北国龙制药有限公司 Preparation method of bromhexine hydrochloride and intermediate thereof

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114195657B (en) * 2022-02-21 2022-05-06 江苏中渊化学品有限公司 Synthetic method of bromhexine hydrochloride suitable for industrialization

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103012167A (en) * 2012-12-16 2013-04-03 石药集团中诺药业（石家庄）有限公司 Preparation method of ambroxol hydrochloride
CN112142604A (en) * 2020-10-28 2020-12-29 河北国龙制药有限公司 Preparation method of bromhexine hydrochloride and intermediate thereof

Also Published As

Publication number Publication date
ES526526A0 (en) 1985-04-16

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