ES8503685A1 - Un procedimiento para preparar derivados de pirazolo (3,4-b) piridina - Google Patents

Un procedimiento para preparar derivados de pirazolo (3,4-b) piridina

Info

Publication number
ES8503685A1
ES8503685A1 ES83525786A ES525786A ES8503685A1 ES 8503685 A1 ES8503685 A1 ES 8503685A1 ES 83525786 A ES83525786 A ES 83525786A ES 525786 A ES525786 A ES 525786A ES 8503685 A1 ES8503685 A1 ES 8503685A1
Authority
ES
Spain
Prior art keywords
producing
pyridine derivatives
new pyrazolo
new
pyrazolo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES83525786A
Other languages
English (en)
Other versions
ES525786A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruppo Lepetit SpA
Original Assignee
Lepetit SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lepetit SpA filed Critical Lepetit SpA
Publication of ES525786A0 publication Critical patent/ES525786A0/es
Publication of ES8503685A1 publication Critical patent/ES8503685A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE PIRAZOLO 3,4-B PIRIDINA.CONSISTE EN: A) HACER REACCIONAR A UN DERIVADO DE PIRAZOLAMINA DE FORMULA (II) CON UN COMPUESTO CARBONILICO DE FORMULA (III), EN UN DISOLVENTE DE ACIDO ORGANICO, PARA OBTENER UN DERIVADO DE FORMULA (IV); Y B) HACER REACCIONAR A (IV) CON UN COMPUESTO DE FORMULA (V) EN UN DISOLVENTE ORGANICO INERTE Y ANHIDRO, PARA OBTENER UN COMPUESTO INTERMEDIO; Y C) CICLIZAR A ESTE COMPUESTO INTERMEDIO EN PRESENCIA DE HALOGENURO DE TIONILO O DE FOSFORILO, PARA OBTENER LOS COMPUESTOS DE FORMULA (I) Y SUS SALES FISIOLOGICAMENTE ACEPTABLES. SIENDO: R Y R, INDEPENDIENTEMENTE, ALQUILO DE C 1 A 6 CICLOALQUILO DE C 3 A 7 Y OTROS; R H, ALQUILO DE C 1 A 4, FENILO Y OTROS; R Y R, ALQUILO DE C 1 A 4, FENILO Y OTROS Y W ES HALOGENO.SE UTILIZAN COMO ANALGESICOS O ANTIINFLAMATORIOS DEL SISTEMA NERVIOSO.
ES83525786A 1982-09-22 1983-09-21 Un procedimiento para preparar derivados de pirazolo (3,4-b) piridina Expired ES8503685A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT23375/82A IT1154024B (it) 1982-09-22 1982-09-22 Derivati pridinici e procedimento per la loro produzione

Publications (2)

Publication Number Publication Date
ES525786A0 ES525786A0 (es) 1985-03-01
ES8503685A1 true ES8503685A1 (es) 1985-03-01

Family

ID=11206534

Family Applications (1)

Application Number Title Priority Date Filing Date
ES83525786A Expired ES8503685A1 (es) 1982-09-22 1983-09-21 Un procedimiento para preparar derivados de pirazolo (3,4-b) piridina

Country Status (10)

Country Link
US (1) US4612318A (es)
EP (1) EP0104522B1 (es)
JP (1) JPS5989679A (es)
AT (1) ATE63913T1 (es)
CA (1) CA1248532A (es)
DE (1) DE3382299D1 (es)
ES (1) ES8503685A1 (es)
GR (1) GR78987B (es)
IT (1) IT1154024B (es)
PT (1) PT77370B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ208555A (en) * 1983-06-23 1987-06-30 American Cyanamid Co (3-amino-1h-pyrazol-4-yl)-arylmethanone derivatives
US4751226A (en) * 1985-09-12 1988-06-14 Fujisawa Pharmaceutical Co., Ltd. Pyrazoloisoquinoline derivatives, plant growth regulating compositions, and method of use therefor
JPH0615542B2 (ja) * 1986-07-22 1994-03-02 吉富製薬株式会社 ピラゾロピリジン化合物
US5006520A (en) * 1987-10-13 1991-04-09 Yoshitomi Pharmaceutical Industries, Ltd. Fused pyrazole compounds and pharmaceutical use thereof
TW444018B (en) 1992-12-17 2001-07-01 Pfizer Pyrazolopyrimidines
DK0765327T3 (da) * 1994-06-16 1999-11-29 Pfizer Pyrazolo- og pyrrolopyridiner
AU2001264313A1 (en) * 2000-06-20 2002-01-02 Japan Tobacco Inc. Pyrazolopyridine compounds and use thereof as drugs
EP1424078A4 (en) * 2001-09-04 2009-03-25 Ono Pharmaceutical Co RESPIRATORY DISEASE MEDICINES COMPRISING A SPHINGOSINE-1-PHOSPHATE RECEPTOR REGULATING AGENT
EP2508204B1 (en) * 2002-06-26 2014-09-24 Ono Pharmaceutical Co., Ltd. Remedies for diseases caused by vascular contraction or dilation
AU2005219518A1 (en) 2004-02-27 2005-09-15 F. Hoffmann-La Roche Ag Indazole derivatives and pharmaceutical compositions containing them
KR100844864B1 (ko) 2004-02-27 2008-07-09 에프. 호프만-라 로슈 아게 헤테로아릴-융합 피라졸로 유도체
CN1926139A (zh) * 2004-02-27 2007-03-07 霍夫曼-拉罗奇有限公司 稠合吡唑衍生物
WO2007023111A2 (en) 2005-08-25 2007-03-01 F. Hoffmann-La Roche Ag P38 map kinase inhibitors and methods for using the same
CN101421268B (zh) * 2006-02-15 2016-01-06 Abbvie公司 作为有效parp抑制剂的吡唑并喹诺酮
EP2379551A1 (en) 2008-12-30 2011-10-26 ArQule, Inc. Substituted pyrazolo [3, 4-b]pyridine compounds
TWI461410B (zh) 2008-12-30 2014-11-21 Arqule Inc 經取代之５，６－二氫－６－苯基苯並〔f〕異喹啉－２－胺化合物類
WO2011159864A1 (en) * 2010-06-17 2011-12-22 Bracco Imaging S.P.A. Jte013 analogs and methods of making and using same
RU2495039C1 (ru) * 2012-07-31 2013-10-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Пермский государственный национальный исследовательский университет" МЕТИЛ 3-МЕТИЛ-5-[2-(4-АРИЛАМИНО)-2-ОКСОАЦЕТИЛ]-1,6-ДИФЕНИЛ-1Н-ПИРАЗОЛО[3,4-b]ПИРИДИН-4-КАРБОКСИЛАТЫ И МЕТИЛ 3-МЕТИЛ-5-[2-(4-АРИЛАМИНО)-2-ОКСОАЦЕТИЛ]-6-СТИРИЛ-1-ФЕНИЛ-1Н-ПИРАЗОЛО[3,4-b]ПИРИДИН-4-КАРБОКСИЛАТЫ И СПОСОБ ИХ ПОЛУЧЕНИЯ
US11498919B2 (en) * 2017-08-23 2022-11-15 Sprint Bioscience Ab Azaindolylpyridone and diazaindolylpyridone compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3403158A (en) * 1966-03-11 1968-09-24 Upjohn Co 1h-pyrazolo[3, 4-b]pyridines
US3681368A (en) * 1970-10-15 1972-08-01 Abbott Lab Pyrazolo naphthridines
BE787249A (fr) * 1971-08-05 1973-02-05 Squibb & Sons Inc Derives amino d'acides pyrazolopyridine carboxyliques, leurs esters et les sels de ces composes, ainsi que leurs procedes de preparation
US3891630A (en) * 1974-03-04 1975-06-24 Abbott Lab Substituted pyrazolo{8 3,4-e{9 {8 1,4{9 thiazepines and isoxazolo{8 5,4-e{9 {8 1,4{9 thiazepines
US3903096A (en) * 1974-03-29 1975-09-02 Squibb & Sons Inc New derivatives of sulfonyl-, sulfinyl- and sulfenyl-1H-pyrazolo {8 3,4-b{9 -pyridines
EP0005745B1 (en) * 1978-05-26 1982-07-14 Gruppo Lepetit S.P.A. Pyrazolo (3,4-c) and thiazolo (5,4-c) isoquinolines, methods for preparing them, these compounds for use as antiinflammatory, cns-depressant and anti-anxiety agents and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
EP0104522B1 (en) 1991-05-29
PT77370A (en) 1983-10-01
ES525786A0 (es) 1985-03-01
ATE63913T1 (de) 1991-06-15
GR78987B (es) 1984-10-02
US4612318A (en) 1986-09-16
EP0104522A3 (en) 1985-06-19
IT1154024B (it) 1987-01-21
PT77370B (en) 1986-04-21
IT8223375A0 (it) 1982-09-22
EP0104522A2 (en) 1984-04-04
CA1248532A (en) 1989-01-10
JPS5989679A (ja) 1984-05-23
DE3382299D1 (de) 1991-07-04

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970401