ES8407485A1 - Un procedimiento de preparacion de nuevos 1(2-carbalcoxi-4-(tienilalquilamido) fenoxi)3-amino 2-propanoles utilizables en terapeutica. - Google Patents
Un procedimiento de preparacion de nuevos 1(2-carbalcoxi-4-(tienilalquilamido) fenoxi)3-amino 2-propanoles utilizables en terapeutica.Info
- Publication number
- ES8407485A1 ES8407485A1 ES524103A ES524103A ES8407485A1 ES 8407485 A1 ES8407485 A1 ES 8407485A1 ES 524103 A ES524103 A ES 524103A ES 524103 A ES524103 A ES 524103A ES 8407485 A1 ES8407485 A1 ES 8407485A1
- Authority
- ES
- Spain
- Prior art keywords
- thienylalkylamido
- propanols
- carbalkoxy
- phenoxy
- therapy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000002560 therapeutic procedure Methods 0.000 title 1
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 abstract 2
- AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000001882 diuretic effect Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229960003712 propranolol Drugs 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 229930192474 thiophene Natural products 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE 1-2-CARBALCOXI-4-(TIEN ILALQUILAMIDO) FENOXI-3-AMINO-2-PROPANOLES, DE FORMULA (I), EN LA QUE N VALE 0 O 1; Y R, R1 Y R2 PUEDEN SER VARIOS TIPOS DE RADICALES; COMPUESTOS QUE TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE LA HIPERTENSION.CONSISTE EN LA REACCION DE UNA BASE DE FORMULA NH2-R1 CON UN COMPUESTO DE FORMULA (II), EN LAS QUE N, R, R1 Y R2 TIENEN LOS MISMOS SIGNIFICADOS QUE EN LA FORMULA (I). LA REACCION SE EFECTUA EN AUSENCIA O PRESENCIA DE UN DISOLVENTE ORGANICO, A UNA TEMPERATURA ENTRE 20JC Y 150JC.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8212499A FR2530245A1 (fr) | 1982-07-16 | 1982-07-16 | Nouveaux 1-(2-carbalkoxy 4-(thienyl-alkylamido)phenoxy) 3-amino 2-propanols, leur preparation et leurs applications en therapeutique |
FR8309361A FR2546890B2 (fr) | 1983-06-06 | 1983-06-06 | Nouveaux derives substitues du 1-(2-carbalkoxy 4-(thienyl carboxamido phenoxy) 3-amino 2-propanol, leur preparation et leurs applications en therapeutique |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8407485A1 true ES8407485A1 (es) | 1984-10-01 |
ES524103A0 ES524103A0 (es) | 1984-10-01 |
Family
ID=26222995
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES524103A Granted ES524103A0 (es) | 1982-07-16 | 1983-07-14 | Un procedimiento de preparacion de nuevos 1(2-carbalcoxi-4-(tienilalquilamido) fenoxi)3-amino 2-propanoles utilizables en terapeutica. |
Country Status (10)
Country | Link |
---|---|
US (1) | US4668801A (es) |
EP (1) | EP0099822B1 (es) |
AU (1) | AU566089B2 (es) |
CA (1) | CA1205478A (es) |
DE (1) | DE3367389D1 (es) |
DK (1) | DK164552C (es) |
ES (1) | ES524103A0 (es) |
GR (1) | GR79194B (es) |
IE (1) | IE56108B1 (es) |
PT (1) | PT77031B (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5268389A (en) * | 1989-10-16 | 1993-12-07 | Uniroyal Chemical Company, Inc. | Thiocarboxylate ester compounds compositions containing the same |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1543689A (fr) * | 1966-11-03 | 1968-10-25 | Ici Ltd | Procédé de fabrication de nouvelles alcanolamines et de leurs dérivés |
GB1185044A (en) * | 1966-11-03 | 1970-03-18 | Ici Ltd | Alkanolamine Derivatives |
GB1531718A (en) * | 1974-11-20 | 1978-11-08 | Pharmacia As | Phenylethanolamines |
DE2923817C2 (de) * | 1979-06-12 | 1981-07-09 | A. Nattermann & Cie GmbH, 5000 Köln | (3-Alkylamino-2-hydroxyproposy)-furan-2-carbonsäureanilide und deren physiologisch verträgliche Säureadditionssalze und Verfahren zu deren Herstellung sowie Arzneimittel mit einem Gehalt dieser Verbindungen |
FR2510573B1 (fr) * | 1981-07-29 | 1985-07-26 | Carpibem | (2-substitue 4-(thienyl acetamido) phenoxy) hydroxy propylamines, leur preparation, leur utilisation en therapeutique, et nouveaux intermediaires |
ZA827646B (en) * | 1981-11-12 | 1983-08-31 | American Hospital Supply Corp | Esters of aryloxypropanolamine derivatives |
-
1983
- 1983-06-27 IE IE1496/83A patent/IE56108B1/en not_active IP Right Cessation
- 1983-07-05 GR GR71869A patent/GR79194B/el unknown
- 1983-07-13 EP EP83401450A patent/EP0099822B1/fr not_active Expired
- 1983-07-13 DE DE8383401450T patent/DE3367389D1/de not_active Expired
- 1983-07-14 ES ES524103A patent/ES524103A0/es active Granted
- 1983-07-14 PT PT77031A patent/PT77031B/pt unknown
- 1983-07-14 CA CA000432423A patent/CA1205478A/en not_active Expired
- 1983-07-15 DK DK326883A patent/DK164552C/da not_active IP Right Cessation
- 1983-07-15 AU AU16868/83A patent/AU566089B2/en not_active Ceased
-
1985
- 1985-12-23 US US06/814,077 patent/US4668801A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE3367389D1 (en) | 1986-12-11 |
GR79194B (es) | 1984-10-22 |
IE56108B1 (en) | 1991-04-24 |
US4668801A (en) | 1987-05-26 |
AU566089B2 (en) | 1987-10-08 |
PT77031B (fr) | 1986-01-28 |
IE831496L (en) | 1984-01-16 |
EP0099822B1 (fr) | 1986-11-05 |
EP0099822A1 (fr) | 1984-02-01 |
ES524103A0 (es) | 1984-10-01 |
DK164552B (da) | 1992-07-13 |
CA1205478A (en) | 1986-06-03 |
AU1686883A (en) | 1984-01-19 |
PT77031A (fr) | 1983-08-01 |
DK326883D0 (da) | 1983-07-15 |
DK164552C (da) | 1992-11-30 |
DK326883A (da) | 1984-01-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970519 |