ES8405407A1 - Un procedimiento para preparar isoxazol(5,4-b)piridinas. - Google Patents

Un procedimiento para preparar isoxazol(5,4-b)piridinas.

Info

Publication number
ES8405407A1
ES8405407A1 ES521083A ES521083A ES8405407A1 ES 8405407 A1 ES8405407 A1 ES 8405407A1 ES 521083 A ES521083 A ES 521083A ES 521083 A ES521083 A ES 521083A ES 8405407 A1 ES8405407 A1 ES 8405407A1
Authority
ES
Spain
Prior art keywords
pyridines
isoxazole
depressant
antiinflammatory
cns
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES521083A
Other languages
English (en)
Other versions
ES521083A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruppo Lepetit SpA
Original Assignee
Gruppo Lepetit SpA
Lepetit SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruppo Lepetit SpA, Lepetit SpA filed Critical Gruppo Lepetit SpA
Publication of ES8405407A1 publication Critical patent/ES8405407A1/es
Publication of ES521083A0 publication Critical patent/ES521083A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/14—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR ISOXAZOL 5,4-B PIRIMIDINAS.CONSISTE EN HACER REACCIONAR CALENTANDO UN COMPUESTO DE FORMULA (II) CON UN ISOCIANATO DE ALCOHILO INFERIOR, EN BASE TERCIARIA A LA TEMPERATURA DE EBULLICION DE DICHA BASE, ENTRE 1 Y 6 HORAS Y PROPORCION 1/1 A 3/1 MOLES Y TRATAR EL COMPUESTO INTERMEDIO OBTENIDO DE FORMULA (III) CON HIDRURO DE SODIO EN DISOLVENTE ANHIDRO, A TEMPERATURA DE 40 A 80JC ENTRE 1 A 3 HORAS PARA OBTENER ISOXAZOL (5,4-B) PIRIDINAS DE FORMULA (I), CON R GRUPO ALCOHILO INFERIOR DE C 1 A 4 Y OTROS, R Y R GRUPOS ALCOHILENOS(CH2)N; CON N DE 3 A 5 Y R ES H U OTROS. REACCIONAR CON EXCESO MOLAR UN AGENTE DE HALOGENACION ENTRE 0 Y 70JC CON EL COMPUESTO DE FORMULA (IV), DONDE R ES UN GRUPO HIDROXI-ALCOHILO INFERIOR Y DONDE LA RAYA DE PUNTOS ES UN DOBLE ENLACE PARA PRODUCIR UN COMPUESTO DE FORMULA (I).TIENEN ACTIVIDAD ANTIINFLAMATORIA, CARDIOVASCULAR Y SEDANTE DEL SNC.
ES521083A 1982-03-30 1983-03-29 Un procedimiento para preparar isoxazol(5,4-b)piridinas. Granted ES521083A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8209361 1982-03-30

Publications (2)

Publication Number Publication Date
ES8405407A1 true ES8405407A1 (es) 1984-06-01
ES521083A0 ES521083A0 (es) 1984-06-01

Family

ID=10529406

Family Applications (1)

Application Number Title Priority Date Filing Date
ES521083A Granted ES521083A0 (es) 1982-03-30 1983-03-29 Un procedimiento para preparar isoxazol(5,4-b)piridinas.

Country Status (13)

Country Link
US (1) US4530927A (es)
EP (1) EP0090275B1 (es)
JP (1) JPS58177992A (es)
AT (1) ATE30425T1 (es)
AU (1) AU561013B2 (es)
CA (1) CA1204440A (es)
DE (1) DE3374199D1 (es)
DK (1) DK143583A (es)
ES (1) ES521083A0 (es)
GR (1) GR77945B (es)
IL (1) IL68171A (es)
PH (1) PH18337A (es)
ZA (1) ZA831738B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2161667B (en) * 1984-07-12 1988-04-27 John Spencer Liggett Portable facial image synthesiser
JPH04368375A (ja) * 1991-06-17 1992-12-21 Otsuka Pharmaceut Factory Inc イソオキサゾール誘導体
AU6299296A (en) * 1995-06-29 1997-01-30 Novo Nordisk A/S Novel substituted azacyclic compounds
CA2451057A1 (en) * 2001-06-14 2002-12-27 Banyu Pharmaceutical Co., Ltd. Novel isoxazolopyridone derivatives and use thereof
GB0124848D0 (en) * 2001-10-16 2001-12-05 Celltech R&D Ltd Chemical compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3381016A (en) * 1966-03-04 1968-04-30 Upjohn Co Isoxazolo[5, 4-b]pyridine derivatives and a method for their preparation
US3541101A (en) * 1966-03-04 1970-11-17 Upjohn Co Isoxazolo(5,4-b)pwridines,5,6 - polymethyleneisoxazolo(5,4 - b)pyridines and processes therefor
US3816429A (en) * 1971-08-10 1974-06-11 Ciba Geigy Corp Tetrahydroisoxazolo(5,4-c)isoquinolines
IT1054655B (it) * 1975-08-27 1981-11-30 Lepetit Spa Derivati condensati del l isochinolina

Also Published As

Publication number Publication date
DK143583D0 (da) 1983-03-29
ATE30425T1 (de) 1987-11-15
DK143583A (da) 1983-10-01
IL68171A (en) 1986-03-31
CA1204440A (en) 1986-05-13
IL68171A0 (en) 1983-06-15
US4530927A (en) 1985-07-23
AU561013B2 (en) 1987-04-30
JPH0342276B2 (es) 1991-06-26
GR77945B (es) 1984-09-25
AU1233083A (en) 1983-10-06
EP0090275A2 (en) 1983-10-05
PH18337A (en) 1985-06-05
EP0090275B1 (en) 1987-10-28
DE3374199D1 (de) 1987-12-03
ES521083A0 (es) 1984-06-01
ZA831738B (en) 1984-01-25
EP0090275A3 (en) 1984-05-02
JPS58177992A (ja) 1983-10-18

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